CAS: 2535-20-8; 6,7-Dimethyl-8-[(2S,3S,4R)-2,3,4,5-Tetrahydroxypentyl]-2,3,4,8-Tetrahydropteridine-2,4-Dione

结构式图片

上下游产品

5-amino-6-(D-ribitylamino)uracil 3-hydroxy-2-butanon dimethylglyoxal 3,4-dihydroxy-2-butanone 4-phosphateriboflavin 6-Methyl-7-oxo-N(8)-(D-ribityl)-7,8-dihydro-Lumazin 5-amino-6-(D-ribitylamino)uracil

合成工艺路线路线简述

  • 合成目标产物 Russupteridine Iv 主要起始原料 D-Glucose
  • (文献来源)合成步骤主要原料 D-Glucose
📜D-Ribamin置于盐酸,Sodium Dithionite,水体系中,化学反应生成6,7-二甲基核糖基2,4-二羟基蝶啶
参考文献:Masuda Et Al.,Chemical And Pharmaceutical Bulletin,1959,Vol. 7,P. 366
标题:Masuda Et Al.,Chemical And Pharmaceutical Bulletin,1959,Vol. 7,P. 366

海关参考信息

专利信息


专利号:EP-0668917-A1
优先权日:1992-11-19
标题 :SYNTHESIS OF RIBOFLAVIN IN YEASTS.

专利号:US-6929933-B1
优先权日:1992-11-19
标题:Riboflavin synthesis in yeast
发明人:REVUELTA DOVAL JOSE LUIS; SANTOS GARCIA MARIA ANGELES; GARCIA-RAMIREZ JOSE JAVIER; GONZALEZ-HERNANDEZ GLORIA ANGE; BUITRAGO SERNA MARIA JOSE
权利人:BASF AG
摘要:The invention describes the riboflavin biosynthesis gene and gene products from yeast. Vectors and recombinant preparation processes for riboflavin are furthermore described. Specifically, the invention relates to the genes for riboflavin biosynthesis in yeast, the proteins encoded therewith and genetic engineering process for the preparation of riboflavin using these genes and gene products. Accordingly, six genes (rib genes), which encode from enzymes of riboflavin biosynthesis starting from GTP, were found in the yeast Saccharomyces cerevisiae and isolated.

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📌 第三方产品分析报告

✅ COA系统入驻 | 共享模式

合成参考文献


参考文献:10.1016/s0021-9258(19)76953-1
摘要:Plaut GWE. Studies on the Stoichiometry of the Enzymic Conversion of 6,7-Dimethyl-8-ribityllumazine to Riboflavin. Journal of Biological Chemistry. 1960 Sep;235(9):PC41–2. doi: 10.1016/s0021-9258(19)76953-1.
参考文献:10.1021/jo0493222
摘要:Illarionov B, Fischer M, Lee CY, Bacher A, Eisenreich W. Rapid Preparation of Isotopolog Libraries by in Vivo Transformation of 13C-Glucose. Studies on 6,7-Dimethyl-8-ribityllumazine, a Biosynthetic Precursor of Vitamin B2. J. Org. Chem. 2004 Jul 17;69(17):5588–94. doi: 10.1021/jo0493222.
参考文献:10.1016/j.jmb.2006.07.037
摘要:Zhang X, Konarev PV, Petoukhov MV, Svergun DI, Xing L, Cheng RH, Haase I, Fischer M, Bacher A, Ladenstein R, Meining W. Multiple assembly states of lumazine synthase: a model relating catalytic function and molecular assembly. J Mol Biol. 2006 Sep 29;362(4):753–70. doi: 10.1016/j.jmb.2006.07.037.
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