📜D-Ribamin置于盐酸,Sodium Dithionite,水体系中,化学反应生成6,7-二甲基核糖基2,4-二羟基蝶啶 参考文献:Masuda Et Al.,Chemical And Pharmaceutical Bulletin,1959,Vol. 7,P. 366 标题:Masuda Et Al.,Chemical And Pharmaceutical Bulletin,1959,Vol. 7,P. 366
专利号:EP-0668917-A1 优先权日:1992-11-19 标题 :SYNTHESIS OF RIBOFLAVIN IN YEASTS.
专利号:US-6929933-B1 优先权日:1992-11-19 标题:Riboflavin synthesis in yeast 发明人:REVUELTA DOVAL JOSE LUIS; SANTOS GARCIA MARIA ANGELES; GARCIA-RAMIREZ JOSE JAVIER; GONZALEZ-HERNANDEZ GLORIA ANGE; BUITRAGO SERNA MARIA JOSE 权利人:BASF AG 摘要:The invention describes the riboflavin biosynthesis gene and gene products from yeast. Vectors and recombinant preparation processes for riboflavin are furthermore described. Specifically, the invention relates to the genes for riboflavin biosynthesis in yeast, the proteins encoded therewith and genetic engineering process for the preparation of riboflavin using these genes and gene products. Accordingly, six genes (rib genes), which encode from enzymes of riboflavin biosynthesis starting from GTP, were found in the yeast Saccharomyces cerevisiae and isolated.
参考文献:10.1016/s0021-9258(19)76953-1 摘要:Plaut GWE. Studies on the Stoichiometry of the Enzymic Conversion of 6,7-Dimethyl-8-ribityllumazine to Riboflavin. Journal of Biological Chemistry. 1960 Sep;235(9):PC41–2. doi: 10.1016/s0021-9258(19)76953-1. 参考文献:10.1021/jo0493222 摘要:Illarionov B, Fischer M, Lee CY, Bacher A, Eisenreich W. Rapid Preparation of Isotopolog Libraries by in Vivo Transformation of 13C-Glucose. Studies on 6,7-Dimethyl-8-ribityllumazine, a Biosynthetic Precursor of Vitamin B2. J. Org. Chem. 2004 Jul 17;69(17):5588–94. doi: 10.1021/jo0493222. 参考文献:10.1016/j.jmb.2006.07.037 摘要:Zhang X, Konarev PV, Petoukhov MV, Svergun DI, Xing L, Cheng RH, Haase I, Fischer M, Bacher A, Ladenstein R, Meining W. Multiple assembly states of lumazine synthase: a model relating catalytic function and molecular assembly. J Mol Biol. 2006 Sep 29;362(4):753–70. doi: 10.1016/j.jmb.2006.07.037.