CAS: 23513-08-8; (S)-5-Hydroxy-1-(4-Hydroxy-3-Methoxyphenyl)Dodecan-3-One

该化合物是一种主要在姜(Zingiber officinale)中发现的生物活性化合物,以其独特的口味和潜在的健康利益著称;它属于被称为苯丙化合物的化合物类别,其特点是附于苯球环的长链脂边链链;8-Gingerol的分子结构包括一个氢氧基化合物,该物质有助于其抗氧化特性;该化合物因其防炎,防甲和止痛效应而得到承认,使其在烹饪和药方面都受到关注;8-Gingerol经常因其潜在的治疗用途而受到研究,包括其在消化健康中的作用及其缓解运动疾病症状的能力;此外,它表现出反微生物特性,可能有助于食品保存;该化合物通常从姜树脂中提取,可以以多种形式找到,包括新鲜姜,干姜粉和补充物;其有机溶剂的稳定性和溶液溶液溶解性使其适合食品科学和药学的各种应用.

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CAS号1135-24-6 阿魏酸 | CAS号502-44-3 ε-己内酯 | CAS号4547-43-7 6-羟基己酸甲酯 | CAS号1135-23-5 3-(4-羟基-3-甲氧苯基)丙酸 | CAS号57371-44-5 3-(4-(苄氧基)-3-甲氧... | CAS号1700-32-9 methyl 4-benzyl... | CAS号56024-44-3 3-(4-羟基-3-甲氧基苯基)丙酸甲酯 | CAS号69172-20-9 3-(3-methoxy-4-... | CAS号146830-53-7 2-[2-(4-Hydroxy...

合成工艺路线路线简述

    📜3-(4-羟基-3-甲氧基苯基)丙酸置于吡啶,Chromium(Vi) Oxide,Lithium Aluminium Tetrahydride,硫酸,三氟化硼乙醚,四丁基氟化铵,四丁基碘化铵,Sodium Hydride,对甲苯磺酸,Calcium Carbonate,碘甲烷体系中,用 四氢呋喃,乙醚,乙醇,二氯甲烷,氯仿,水,乙腈 用作溶剂,化学反应 37.0H,反应生成[8]-姜酚
    参考文献:Total Synthesis Of Natural Gingerols,The Three Active Principles Of Ginger
    标题:Total Synthesis Of Natural Gingerols,The Three Active Principles Of Ginger
    摘要:Natural Gingerols,(+)(S)[6]-,(+)(S)[8]-,And (+)(S)[10]-Gingerols,The Three Active Principles Of Ginger,Have Been Prepared From A Common Optically Active Intermediate 9 Which Was Readily Made By Asymmetric Synthesis From A Chiral Beta-Keto Sulfoxide 5.
    Doi:10.1021/jo00060A038

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    专利信息


    专利号:CN-103159600-A
    优先权日:2013-03-27
    标 题:Chemical Synthesis Process of Gingerol

    专利号:CN-115299543-B
    优先权日:2022-08-12
    标 题:A kind of solid beverage that promotes the synthesis and metabolism of human dopamine and its preparation method

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    主要参考文献


    1: Bernard M, Furlong SJ, Power Coombs MR, Hoskin DW. Differential Inhibition of T Lymphocyte Proliferation and Cytokine Synthesis by [6]-Gingerol, [8]-Gingerol, and [10]-Gingerol. Phytother Res. 2015 Nov;29(11):1707-13. doi: 10.1002/ptr.5414. doi: 10.1016/S2221-1691(13)60128-8.
    3: Huang HC, Chou YC, Wu CY, Chang TM. [8]-Gingerol inhibits melanogenesis in murine melanoma cells through down-regulation of the MAPK and PKA signal pathways. Biochem Biophys Res Commun. 2013 Aug 23;438(2):375-81. doi: 10.1016/j.bbrc.2013.07.079. doi: 10.3390/molecules16032636. doi: 10.1016/j.jep.2009.10.004. doi: 10.1016/j.jchromb.2009.01.021. doi: 10.1158/1055-9965.EPI-07-2934.
    8: Schwertner HA, Rios DC. High-performance liquid chromatographic analysis of 6-gingerol, 8-gingerol, 10-gingerol, and 6-shogaol in ginger-containing dietary supplements, spices, teas, and beverages. J Chromatogr B Analyt Technol Biomed Life Sci. 2007 Sep 1;856(1-2):41-7.

    合成参考文献


    摘要:Zhongguo Yaoxue Zazhi. Chinese Pharmacuetical Journal., 25(231), 1990
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