CAS: 224177-60-0; 1'-[4-[1-(4-Fluorophenyl)-1H-Indole-3-Yl]-1-Butyl]-Spiro[isobenzofuran-1(3H),4'-Piperidine], Hydrochloride

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    📜西拉美新,盐酸 以 2-Propanole 用作溶剂,化学反应生成西拉美新盐酸盐
    参考文献:1'-[4-[1-(4-Fluorophenyl)-1H-Indole-3-Yl]-1-Butyl]-Spiro[isobenzofuran-1(3H),4'-Piperidine] Hydrohalogenides
    标题:1'-[4-[1-(4-Fluorophenyl)-1H-Indole-3-Yl]-1-Butyl]-Spiro[isobenzofuran-1(3H),4'-Piperidine] Hydrohalogenides
    摘要:本发明涉及1'-[4-[1-(4-氟苯基)-1H-吲哚-3-基]-1-丁基]-螺[异苯并[1(3H),4'-哌啶]]的氢卤化物,含有酸加成盐的制药组合物以及其用于治疗心理和神经系统疾病的用途.

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    主要参考文献


    1: Česen MH, Repnik U, Turk V, Turk B. Siramesine triggers cell death through destabilisation of mitochondria, but not lysosomes. Cell Death Dis. 2013 Oct 3;4:e818. doi: 10.1038/cddis.2013.361.
    2: Spirkoski J, Melo FR, Grujic M, Calounova G, Lundequist A, Wernersson S, Pejler G. Mast cell apoptosis induced by siramesine, a sigma-2 receptor agonist. Biochem Pharmacol. 2012 Dec 15;84(12):1671-80. doi: 10.1016/j.bcp.2012.09.028. doi: 10.1038/cddis.2016.208.
    4: Ostenfeld MS, Høyer-Hansen M, Bastholm L, Fehrenbacher N, Olsen OD, Groth-Pedersen L, Puustinen P, Kirkegaard-Sørensen T, Nylandsted J, Farkas T, Jäättelä M. Anti-cancer agent siramesine is a lysosomotropic detergent that induces cytoprotective autophagosome accumulation. Autophagy. 2008 May;4(4):487-99.

    合成参考文献


    参考文献:10.1007/s11095-008-9783-0
    摘要:Zimmermann A, Tian F, Lopez de Diego H, Ringkjøbing Elema M, Rantanen J, Müllertz A, Hovgaard L. Influence of the solid form of siramesine hydrochloride on its behavior in aqueous environments. Pharm Res. 2009 Apr;26(4):846–54. doi: 10.1007/s11095-008-9783-0.
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