CAS: 1802929-43-6; 8-(3-(4-Acryloylpiperazin-1-yl)Propyl)-6-(2,6-Dichloro-3,5-Dimethoxyphenyl)-2-(Methylamino)Pyrido[2,3-D]Pyrimidin-7(8H)-One

主要参考文献

1: Brameld KA, Owens TD, Verner E, Venetsanakos E, Bradshaw JM, Phan VT, Tam D, Leung K, Shu J, LaStant J, Loughhead DG, Ton T, Karr DE, Gerritsen ME, Goldstein DM, Funk JO. Discovery of the Irreversible Covalent FGFR Inhibitor 8-(3-(4-Acryl oylpiperazin-1-yl)propyl)-6-(2,6-dichloro-3,5-dimethoxyphenyl)-2-(methylamino)py rido[2,3-d]pyrimidin-7(8H)-one (PRN1371) for the Treatment of Solid Tumors. J Med Chem. 2017 Aug 10;60(15):6516-6527. doi: 10.1021/acs.jmedchem.7b00360. Epub 2017 Jul 25. 16(12):2668-2676. doi: 10.1158/1535-7163.MCT-17-0309. Epub 2017 Oct 4.
151:104567. doi: 10.1016/j.phrs.2019.104567. Epub 2019 Nov 23.
4: Fernandez, D., & Godoy, L. (2014). 26th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics-Barcelona, Spain-November 18-21, 2014. Drugs of the Future, 39(12).

合成参考文献

参考文献:10.1021/acs.jmedchem.7b00360
摘要:Brameld KA, Owens TD, Verner E, Venetsanakos E, Bradshaw JM, Phan VT, Tam D, Leung K, Shu J, LaStant J, Loughhead DG, Ton T, Karr DE, Gerritsen ME, Goldstein DM, Funk JO. Discovery of the Irreversible Covalent FGFR Inhibitor 8-(3-(4-Acryloylpiperazin-1-yl)propyl)-6-(2,6-dichloro-3,5-dimethoxyphenyl)-2-(methylamino)pyrido[2,3-d]pyrimidin-7(8H)-one (PRN1371) for the Treatment of Solid Tumors. J. Med. Chem. 2017 Jul 25;60(15):6516–27. doi: 10.1021/acs.jmedchem.7b00360.