专利号:US-5442070-A 优先权日:1991-10-10 标 题:Derivatives of fluoro-quinoline carboxylic-3-acid and preparation therefor 发明人:DAUBIE CHRISTOPHE; LEGRAND JEAN-JACQUES; PEMBERTON CLIVE 权利人:BELLON LABOR SA ROGER 摘要:This invention relates to new derivatives of fluoro quinoline carboxylic-3 acid having general formula (I), ##STR1## wherein R is a hydrogen atom or an alkyl radical and Hal is a halogen atom, as well as salts thereof, when they exist, preparation thereof and utilization as synthesis intermediary.
专利号:US-7737166-B2 优先权日:2005-08-17 标 题:Antifungal bicyclic hetero ring compounds 发明人:KAWAKAMI KATSUHIRO; KANAI KAZUO; HORIUCHI TAKAO; TAKESHITA HIROSHI; KOBAYASHI SYOZO; SUGIMOTO YUICHI; ACHIWA ISSEI; KUROYANAGI JUNICHI 权利人:DAIICHI SANKYO CO LTD 摘要:A 1,6-β-glucan synthetase inhibitor is provided, having potent growth inhibition and having excellent safety. A compound is provided, capable of expressing in a wide spectral range and specifically or selectively, an antifungal effect based on its functional mechanism of 1,6-β-glucan synthesis inhibition. Also provided is a drug, a salt or hydrate thereof, especially an antifungal that contains the compound. Concretely, provided is a compound of the following formula (I), its salt or hydrate, and a drug or antifungal containing, as the active ingredient, the compound, its salt or hydrate:
参考文献:10.1055/s-0036-1591882 摘要:Chen Y, Aurell C, Korsgren P, Malm J, Härslätt M, Fridén-Saxin M, Pettersen A. A Convenient Synthetic Approach to Saccharin Derivatives Containing a Sulfonylamidine Scaffold. Synthesis. 2018 Jan 11;50(07):1471–81. doi: 10.1055/s-0036-1591882.