CAS: 1513-25-3; 2-Chloro-1-Fluoro-4-Methylbenzene

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85089-31-2 1057670-04-8 5527-94-6

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CAS号615-65-6 2-氯-4-甲基苯胺 | CAS号79-35-6 1,1-二氯-2,2-二氟乙烯 | CAS号78-79-5 异戊二烯 | CAS号452-84-6 2-氟-5-甲基苯胺 | CAS号192702-01-5 3-氯-4-氟溴苄 | CAS号7731-00-2 3-Chloro-4-fluo...

2-氟-5-甲基苯胺 反应生成3-氯-4-氟甲苯
参考文献:实验诱导的苯丙酮尿症.I.苯丙氨酸羟化酶的抑制剂.
标题:实验诱导的苯丙酮尿症.I.苯丙氨酸羟化酶的抑制剂.
摘要:
Doi:10.1021/jm00313A013

专利信息

专利号:US-6156922-A
优先权日:1995-12-28
标题 :Method for the synthesis of an aromatic derivative ortho-disubstituted by a halogen atom other than fluorine and by a cyano group
发明人：RUSSELL JAMES; GILBERT LAURENT; MAESTRO JEAN PIERRE
权利人:RHODIA CHIMIE SA
摘要:PCT No. PCT/FR96/02100 Sec. 371 Date Sep. 15, 1998 Sec. 102(e) Date Sep. 15, 1998 PCT Filed Dec. 27, 1996 PCT Pub. No. WO97/24318 PCT Pub. Date Jul. 10, 1997The present invention relates to a method for the synthesis of a halogen substituted aryl nitrile, where the halogens are selected from Cl, Br, or I, by reacting an aryl dihalide with a halogen/fluoride exchange reactant to produce a halogen substituted aryl fluoride which is then reacted with a fluoride/cyanide exchange reactant to produce the halogen substituted aryl nitrile.

专利号:WO-2014183560-A1
优先权日:2013-05-16
标题 :Afatinib and preparation method of intermediate thereof
发明人：XU XUENONG
权利人:SUZHOU MIRACPHARMA TECHNOLOGY CO LTD; XU XUENONG
摘要:Disclosed are a compound of 6-amino-7-hydroxy-3,4-dihydroquinazolin-4-one (I) which can be used in the preparation of Afatinib and the preparation method thereof, the method comprising the following steps: using 3-amino-4-hydroxy benzoic acid or 3-amino-4-hydroxy benzoate or 3-amino-4-hydroxy benzamide as raw materials to prepare the target compound (I) via nitration, reduction and cyclization reactions successively. At the same time, the present invention also reveals two synthesis routes which use compound (I) as a raw material to prepare Afatinib. The preparation and use of compound (I) make the synthesis of Afatinib more simple and environmental, and the yield and quality are improved, thus facilitating industrialization.

专利号:US-9771356-B2
优先权日:2012-09-21
标题 :Inhibitors of beta-hydroxylase for treatment of cancer
发明人：WANDS JACK R; DE LA MONTE SUZANNE; AIHARA ARIHIRO; OLSEN MARK JON; THOMAS JOHN-MICHAEL
权利人:RHODE ISLAND HOSPITAL; UNIV MIDWESTERN
摘要:The present invention relates to compounds which modulate (e.g., inhibit) the activity of beta-hydroxylase (e.g., Asparatyl (asparaginyl) β-hydroxylase (ASPH)), including novel 2-aryl-5-amino-3(2H)-furanone and 2-heteroaryl-5-amino-3(2H)-furanone compounds, pharmaceutical compositions thereof, methods for their synthesis, and methods of using these compounds to modulate the activity of ASPH in an a cell-free sample, a cell-based assay, and in a subject. Other aspects of the invention relate to use of the compounds disclosed herein to ameliorate or treat cell proliferation disorders.

专利号:WO-2011161615-A1
优先权日:2010-06-24
标题 :5-lipoxygenase inhibitors
发明人：VERMA ASHWANI KUMAR; MALHOTRA SANJAY; MARIMGANTI SRINIVASA; RAY ABHIJIT; GUPTA SUMAN; SRIVASTAVA PUNIT; DASTIDAR SUNANDA GHOSH
权利人:RANBAXY LAB LTD; VERMA ASHWANI KUMAR; MALHOTRA SANJAY; MARIMGANTI SRINIVASA; RAY ABHIJIT; GUPTA SUMAN; SRIVASTAVA PUNIT; DASTIDAR SUNANDA GHOSH
摘要:The present invention relates to pyrazole derivatives of formula 1 and to process as for their synthesis as 5-lipoxygenase (5-LO) inhibitors. The present invention also relates to pharmacological compositions containing these pyrazole derivatives, as well as, methods of treating bronchial asthma, chronic obstructive pulmonary disease, rheumatoid arthritis, multiple sclerosis, Type I diabetes, psoriasis, allograft rejection, inflammatory bowel disease, ulcerative colitis, acne, atherosclerosis, cancer, pruritis, allergic rhinitis and other inflammatory and/or autoimmune disorders.

专利号:RU-2170230-C2
优先权日:1995-12-08
标 题:Novel derivatives of pyrazole, method of their synthesis and pharmaceutical compositions containing thereof