CAS: 1480-87-1; 2-Fluoro-3-Nitropyridine

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2-氨基-3-硝基吡啶置于氟化氢吡啶,Sodium Nitrite体系中,用97%的收率获得2-氟-3-硝基吡啶
参考文献:氟化氢与碱结合,通过氨基芳烃的脱氨基氟化,轻松制备芳族氟化物
标题:氟化氢与碱结合,通过氨基芳烃的脱氨基氟化,轻松制备芳族氟化物
摘要:通过将氟化氢与碱溶液结合使用,成功地实现了包括杂芳族化合物在内的氨基芳烃的一锅式脱氨氟化,即氨基芳烃的重氮化,然后将相应的重氮离子进行原位氟脱氮,以高产率生产了氟芳烃.已发现重氮化阶段在有效生产氟代芳烃中起着最重要的作用.它受到hf溶液组成的极大影响,并通过在谨慎控制的条件下使用适量的碱(例如吡啶)来增强.光化学方法有效地促进了氟脱重氮化阶段,从而以高收率提供了具有极性取代基(如羟基,硝基等)的氟代芳烃.
Doi:10.1016/0040-4020(95)00867-8

专利信息

专利号:US-8362019-B2
优先权日:2008-02-01
标 题:Synthesis and anti-proliferative effect of substituted imidazo[4,5-b]pyrazine compounds
发明人：WINFIELD LEYTE L
权利人:SPELMAN COLLEGE; WINFIELD LEYTE L
摘要:This invention provides for compounds, compositions, and methods that involve anti-proliferative and anti-neoplastic activity in cancer cells. In particular, a series of benzimidazole, purine, imidazopyridine, and imidazopyrizine compounds having selected substitution patterns are disclosed, and the activity of various subject compounds is demonstrated. In particular, the disclosure provides for substituted imidazo[4,5-b]pyrazine compounds having the general formula n ntheir salts, pharmaceutical compositions, and methods of treatment using the subject compounds and compositions.

专利号:US-2012095038-A1
优先权日:2008-02-01
标 题:Synthesis and anti-proliferative effect of benzimidazole derivatives

专利号:US-2012095009-A1
优先权日:2008-02-01
标题 :Synthesis and anti-proliferative effect of benzimidazole derivatives

专利号:US-2012095037-A1
优先权日:2008-02-01
标题:Synthesis and anti-proliferative effect of benzimidazole derivatives

专利号:US-2012095027-A1
优先权日:2008-02-01
标题:Synthesis and anti-proliferative effect of benzimidazole derivatives

专利号:US-2011152278-A1
优先权日:2008-02-01
标 题 :Synthesis and anti-proliferative effect of benzimidazole derivatives