CAS: 115175-22-9; 3-Amino-N-(3-Chlorophenyl)Benzamide

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3-Nitro-benzoesaeure-3-chlor-anilid 3-chloro-aniline m-nitrobenzoic acid chloride

📜间硝基苯甲酰氯置于盐酸,Tin,三乙胺体系中,用 四氢呋喃,二氯甲烷 用作溶剂,化学反应 1.08H,反应生成硼烷-三甲胺络合物
参考文献:Synthesis And Antiviral Activity Of Sulfonamidobenzophenone Oximes And Sulfonamidobenzamides
标题:Synthesis And Antiviral Activity Of Sulfonamidobenzophenone Oximes And Sulfonamidobenzamides
摘要:To Find Antiviral Agents,Various Sulfonamidobenzophenone Oximes (II) Were Synthesized From The Appropriate M-Sulfonamidobenzophenones By Hydroxylamine Reaction. The Reaction Products Were Generally Obtained As Syn/anti Mixtures Which Were Separable By Fractional Crystallization. The Anti Isomer Had More Potent Antipoliovirus Activity Than The Syn Isomer. Various Sulfonamidobenzamides (III) Which Were Structurally Related To Ii Were Synthesized By The Reactions Of Amino-Substituted Benzamides With Sulfuryl Chloride Or Amines With (Aminosulfonyl)Benzoyl Chloride. Antiviral Activity Was Examined By The Plaque-Inhibition Test. Compounds 5,36,And 69 Exhibited Strong Antipicornavirus Activity. The Structure-Activity Relationships Are Discussed.
Doi:10.1021/jm00153A018