CAS: 93-88-9; Phenpromethamine

上下游产品

2-苯基丙基胺 2-Phenylpropylamine 582-22-9
N-甲基-1-苯基-1-甲基乙酰胺 N-Methyl-1-Phenyl-1-Methylacetamide 13490-93-2

📜2-苯基丙酸置于(μ3,η2,η3,η5-Acenaphthylene)Ru(Co)7 氯化亚砜,1,1,3,3-四甲基二硅氧烷,三乙胺体系中,用 乙二醇二甲醚,乙醚,苯 作为反应溶剂,化学反应 12.0H,反应生成 苯丙甲胺
参考文献:钌催化的仲酰胺与氢硅烷的还原和还原性n-烷基化:通过明智地选择氢化硅烷来实际合成仲胺和叔胺
标题:钌催化的仲酰胺与氢硅烷的还原和还原性n-烷基化:通过明智地选择氢化硅烷来实际合成仲胺和叔胺
摘要:甲羰基三钌簇,(μ 3,η 2,η 3,η 5-Acenaphthylene)的ru 3(co)7(1)催化仲酰胺与氢硅烷的反应,反应生成仲胺,叔胺和甲硅烷基烯胺的混合物.通过使用较高浓度的催化剂(3 Mol%)和使用双官能氢硅烷(例如1,1,3,3-四甲基二硅氧烷),可以实现具有完全选择性的仲胺的生产.对反应混合物进行酸性处理后,可得到相应的铵盐,可用碱进行处理,从而为分离高纯度仲胺提供了一种简便的方法.相反,通过使用较低浓度的催化剂(1Mol%)和聚合氢硅氧烷(pmhs)作为还原剂,以高选择性形成叔胺.用pmhs还原将钌催化剂和有机副产物封装到不溶性有机硅树脂中.这两个反应歧管适用于各种仲酰胺,并且实用性在于该程序提供所需的仲胺或叔胺作为单一产物.产品仅被少量的钌和硅残留物污染.基于产物和观测到的副产物以及NMR研究,还描述了反应的机理方案.
DOI:10.1021/jo070591C

专利信息

专利号:US-2023151034-A1
优先权日:2020-03-17
标题:Peptidomimetic n5-methyl-n2-(nonanoyl-l-leucyl)-l-glutaminate derivatives, triazaspiro[4.14]nonadecane derivatives and similar compounds as inhibitors of norovirus and coronavirus replication
发明人：JACOBSON IRINA C; LEE SAM SK; PIZARRO NOVOA JUAN CARLOS
权利人:COCRYSTAL PHARMA INC
摘要:Peptidomimetic N5-methyl-N2-(nonanoyl-L-leucyl)-L-glutaminate derivatives, triazaspiro[4.14]nonadecane derivatives and similar compounds for use in methods of inhibiting the replication of noroviruses and coronaviruses in a biological sample or patient, for use in reducing the amount of noroviruses or coronaviruses in a biological sample or patient, and for use in treating norovirus and coronavirus in a patient, comprising administering to said biological sample or patient a safe and effective amount of a compound represented by formulae I or II, or a pharmaceutically acceptable salt thereof. The present description discloses the synthesis and characterisation of exemplary compounds as well as pharmacological data thereof (e.g. page 99 to page 271; examples 1 to 3; compounds A1 to A104 and B1 to B66; tables A to E).

专利号:CN-110157001-A
优先权日:2018-10-19
标 题:The synthesis and application of fan-shaped dendroid polylysine containing hydrophobic cores