专利号:US-4311645-A 优先权日:1980-03-24 标 题 :Synthesis of SRS-active compounds 发明人:ROSENBERGER MICHAEL 权利人:HOFFMANN LA ROCHE 摘要:A chemical synthesis of an SRS-A active compound from the reaction product of 1-halo-2-octyne and the ether of 2-penten-4-yn-1-ol including intermediates in the synthesis, some of which being antagonists of SRS-A useful for treating allergic reactions.
专利号:US-7820795-B2 优先权日:2004-03-30 标 题:Lactobacillus fermentum N-desoxyribosyl transferases and the use thereof for enzymatic synthesis of 2′, 3′—didesoxynucleosides and 2′,3′- didehydro-2′,3′- didesoxynucleosides 发明人:KAMINSKI PIERRE-ALEXANDRE 权利人:PASTEUR INSTITUT 摘要:N-deoxyribosyl transferases of Lactobacillus fermentum and their analogues, as well their use for the enzymatic synthesis of 2′,3′-dideoxynucleosides and 2′,3′-didehydro-2′,3′-dideoxynucleosides. These transferases and their analogues include a N-deoxyribosyl transferase protein (DTP) that has at least 70%-95% identity with the polypeptide of SEQ ID NO: 2 or SEQ ID NO: 4, that retains residues Y13, D77, D97, E103, and M312 which respectively correspond to positions 13, 77, 97, 103, and 132 of SEQ ID NO: 2; and that has threonine at a position corresponding to position 15 of SEQ ID NO: 2 or SEQ ID NO: 4. Polynucleotides, vectors and host cells encoding these N-deoxyribosyl transferases and their analogues.
专利号:WO-2004099229-A1 优先权日:2003-05-06 标题:Process for the synthesis of base addition salts of 2,3-0-isopropylidene-1-0-substituted-5,6-dideoxy-5-n- (4-(2-hydroxy-2-oxoethyl)-phenylaminocarbonyl) amino-l-gulofuranosides 发明人:KHANNA JAG MOHAN; YADAV GYAN CHAND; RAY ABHIJIT; KRISHNA NARUGANAHALLI SIDDARAN 权利人:RANBAXY LAB LTD; KHANNA JAG MOHAN; YADAV GYAN CHAND; RAY ABHIJIT; KRISHNA NARUGANAHALLI SIDDARAN 摘要:The present invention relates to processes for the synthesis of base addition salts of particular ß-L- gulofuranosides. More specifically, the invention relates to synthetic processes for making base addition salts of 2,3-O-isopropylidene-1-O-substituted-5,6-dideoxy-5-N-[4-(2-hydroxy-2-oxoethy)-phenylaminocarbony]amino-ß-L-gulofuranosides.
专利号:US-2008096242-A1 优先权日:2004-09-01 标 题 :Enhanced Substrate Conversion Efficiency Of Fermentation Processes 发明人:SANDERS JOHAN P M; WEUSTHUIS RUUD A; MOOIBROEK ANDREAS 权利人:AGROTECHNOLOGY AND FOOD INNOVA 摘要:The present invention relates to the field of fermentation technology. In particular the invention relates to fermentation processes for the production of a first and a second fermentation product by a single production organism wherein the first product is in a more reduced state than the substrate and the second fermentation product is in a more oxidised state than the substrate yet in a less oxidised state than the final oxidation product CO 2 , such that the concurrent synthesis of the first and second product in the organism allows recycling of reducing power and can be performed under (partially) anaerobic conditions. The invention also relates to such processes in which the first and second fermentation products are capable of forming a(n) (insoluble) complex or salt.
专利号:US-7919505-B2 优先权日:2006-07-11 标题 :Xinafoate salt of a substituted 5-oxazol-2-yl-quinoline compound 发明人:TING PAULINE C; LEE JOE F; FENG KUNG-I; REEDER MICHAEL R; TRZASKA SCOTT T; ZHU MAN; MAO CHEN; FILIPOV DIMITAR L; ZARKADAS DIMITRIOS N 权利人:SCHERING CORP 摘要:The present invention relates to the compound of the formula n nTo methods of treating upper and lower obstructive airway diseases using said compound, to formulations comprising it, and to polymorphs and processes of synthesis of the polymorphic forms.
专利号:US-2013035307-A1 优先权日:2010-01-26 标 题:Methods for treating or preventing the spread of cancer using semi-synthetic glycosaminoglycosan ethers 发明人:PRESTWICH GLENN D; KENNEDY THOMAS P 权利人:UNIV UTAH RES FOUND; PRESTWICH GLENN D; KENNEDY THOMAS P 摘要:Described herein are methods for the treatment and prevention of tumor metastasis using alkylated and fluoroalkylated semi-synthetic glycosaminoglycan ethers (“SAGEsâ€?). The synthesis of sulfated alkylated and fluoroalkylated SAGEs is also described.
1: Jain S, Panyutin A, Liu N, Xiao C, Piñol RA, Pundir P, Girardet C, Butler AA, Dong X, Gavrilova O, Reitman ML. Melanotan II causes hypothermia in mice by activation of mast cells and stimulation of histamine 1 receptors. Am J Physiol Endocrinol Metab. 2018 May 29. doi: 10.1152/ajpendo.00024.2018. [Epub ahead of print] doi: 10.1016/j.pbb.2018.04.010. [Epub ahead of print] doi: 10.3389/fphar.2018.00038. eCollection 2018. 6: Stoddart LA, Vernall AJ, Bouzo-Lorenzo M, Bosma R, Kooistra AJ, de Graaf C, Vischer HF, Leurs R, Briddon SJ, Kellam B, Hill SJ. Development of novel fluorescent histamine H(1)-receptor antagonists to study ligand-binding kinetics in living cells. Sci Rep. 2018 Jan 25;8(1):1572. doi: 10.1038/s41598-018-19714-2. 7: Akanuma SI, Yamazaki Y, Kubo Y, Hosoya KI. Role of cationic drug-sensitive transport systems at the blood-cerebrospinal fluid barrier in para-tyramine elimination from rat brain. Fluids Barriers CNS. 2018 Jan 8;15(1):1. doi: 10.1186/s12987-017-0087-9.
合成参考文献
参考文献:10.1530/rep.1.00737 摘要:Kobayashi D, Irokawa M, Maeda T, Tsuji A, Tamai I. Carnitine/organic cation transporter OCTN2-mediated transport of carnitine in primary-cultured epididymal epithelial cells. Reproduction. 2005 Dec;130(6):931–7. doi: 10.1530/rep.1.00737. 参考文献:10.1007/s00424-011-0995-5 摘要:López-Izquierdo A, Aréchiga-Figueroa IA, Moreno-Galindo EG, Ponce-Balbuena D, Rodríguez-Martínez M, Ferrer-Villada T, Rodríguez-Menchaca AA, van der Heyden MAG, Sánchez-Chapula JA. Mechanisms for Kir channel inhibition by quinacrine: acute pore block of Kir2.x channels and interference in PIP2 interaction with Kir2.x and Kir6.2 channels. Pflügers Archiv - European Journal of Physiology. 2011 Jul 22;462(4):505. doi: 10.1007/s00424-011-0995-5.