CAS: 91-84-9; N1-(4-Methoxybenzyl)-N2,N2-Dimethyl-N1-(Pyridin-2-yl)Ethane-1,2-Diamine

该化合物是一种属于烷胺类的抗脊髓灰质炎,主要用于缓解干热和泌尿素等过敏症状,阻断H1受体的抗脊胺作用. 甲胺通常以白色的形式呈现为白色,以脱白结晶粉形式出现,在水和酒精中溶解.其化学配方为C16H20N2,分子重量约为244.5克/毫醇. 化合物的脂质和用量均中度至高,有助于其跨越血脑屏障的能力,并可能导致镇静剂效应. 甲胺通常与其他药剂结合使用,如许多抗脊髓灰质素制剂,可能会产生副作用,如嗜水性,干口和眩晕. 适当的剂量和使用对于最大限度地减少不良影响并确保治疗过敏反应的功效至关重要.

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CAS号2746-25-0 4-甲氧基溴苄 | CAS号824-94-2 4-甲氧基苄氯 | CAS号107-99-3 2-氯-N,N-二甲基乙胺 | CAS号104499-47-0 N-(4-甲氧基苄基)-N'-...

合成工艺路线路线简述

    📜N-(4-Methoxybenzyl)Methanimine Oxide置于tris-(Dibenzylideneacetone)Dipalladium(0),2-(二环己基膦)3,6-二甲氧基-2',4',6'-三异丙基-1,1'-联苯,[ir(Df(Cf3)Ppy)2(Dtbbpy)](Pf6),Sodium Tert-Pentoxide,Lithium Carbonate,溶剂黄146,锌体系中,用 水,N,N-二甲基甲酰胺,甲苯 作为反应溶剂,化学反应 47.0H,反应生成 美吡拉敏
    参考文献:光氧化还原催化的α-氨基酸与硝酮的脱羧交叉偶联
    标题:光氧化还原催化的α-氨基酸与硝酮的脱羧交叉偶联
    摘要:建立了α-氨基酸与硝酮通过可见光诱导的光氧化还原催化的脱羧交叉偶联反应,易于获得具有结构多样性的β-氨基羟胺和邻二胺,具有操作简单,条件温和,容易获得的特点.可用的α-氨基酸,以及广泛的硝酮底物.该协议的应用可以为一些有价值的含有连二胺的分子提供有效的合成策略.
    DOI:10.1021/acs.Orglett.0C04101

    海关参考信息

    专利信息


    专利号:US-4311645-A
    优先权日:1980-03-24
    标 题 :Synthesis of SRS-active compounds
    发明人:ROSENBERGER MICHAEL
    权利人:HOFFMANN LA ROCHE
    摘要:A chemical synthesis of an SRS-A active compound from the reaction product of 1-halo-2-octyne and the ether of 2-penten-4-yn-1-ol including intermediates in the synthesis, some of which being antagonists of SRS-A useful for treating allergic reactions.

    专利号:US-7820795-B2
    优先权日:2004-03-30
    标 题:Lactobacillus fermentum N-desoxyribosyl transferases and the use thereof for enzymatic synthesis of 2′, 3′—didesoxynucleosides and 2′,3′- didehydro-2′,3′- didesoxynucleosides
    发明人:KAMINSKI PIERRE-ALEXANDRE
    权利人:PASTEUR INSTITUT
    摘要:N-deoxyribosyl transferases of Lactobacillus fermentum and their analogues, as well their use for the enzymatic synthesis of 2′,3′-dideoxynucleosides and 2′,3′-didehydro-2′,3′-dideoxynucleosides. These transferases and their analogues include a N-deoxyribosyl transferase protein (DTP) that has at least 70%-95% identity with the polypeptide of SEQ ID NO: 2 or SEQ ID NO: 4, that retains residues Y13, D77, D97, E103, and M312 which respectively correspond to positions 13, 77, 97, 103, and 132 of SEQ ID NO: 2; and that has threonine at a position corresponding to position 15 of SEQ ID NO: 2 or SEQ ID NO: 4. Polynucleotides, vectors and host cells encoding these N-deoxyribosyl transferases and their analogues.

    专利号:WO-2004099229-A1
    优先权日:2003-05-06
    标题:Process for the synthesis of base addition salts of 2,3-0-isopropylidene-1-0-substituted-5,6-dideoxy-5-n- (4-(2-hydroxy-2-oxoethyl)-phenylaminocarbonyl) amino-l-gulofuranosides
    发明人:KHANNA JAG MOHAN; YADAV GYAN CHAND; RAY ABHIJIT; KRISHNA NARUGANAHALLI SIDDARAN
    权利人:RANBAXY LAB LTD; KHANNA JAG MOHAN; YADAV GYAN CHAND; RAY ABHIJIT; KRISHNA NARUGANAHALLI SIDDARAN
    摘要:The present invention relates to processes for the synthesis of base addition salts of particular ß-L- gulofuranosides. More specifically, the invention relates to synthetic processes for making base addition salts of 2,3-O-isopropylidene-1-O-substituted-5,6-dideoxy-5-N-[4-(2-hydroxy-2-oxoethy)-phenylaminocarbony]amino-ß-L-gulofuranosides.

    专利号:US-2008096242-A1
    优先权日:2004-09-01
    标 题 :Enhanced Substrate Conversion Efficiency Of Fermentation Processes
    发明人:SANDERS JOHAN P M; WEUSTHUIS RUUD A; MOOIBROEK ANDREAS
    权利人:AGROTECHNOLOGY AND FOOD INNOVA
    摘要:The present invention relates to the field of fermentation technology. In particular the invention relates to fermentation processes for the production of a first and a second fermentation product by a single production organism wherein the first product is in a more reduced state than the substrate and the second fermentation product is in a more oxidised state than the substrate yet in a less oxidised state than the final oxidation product CO 2 , such that the concurrent synthesis of the first and second product in the organism allows recycling of reducing power and can be performed under (partially) anaerobic conditions. The invention also relates to such processes in which the first and second fermentation products are capable of forming a(n) (insoluble) complex or salt.

    专利号:US-7919505-B2
    优先权日:2006-07-11
    标题 :Xinafoate salt of a substituted 5-oxazol-2-yl-quinoline compound
    发明人:TING PAULINE C; LEE JOE F; FENG KUNG-I; REEDER MICHAEL R; TRZASKA SCOTT T; ZHU MAN; MAO CHEN; FILIPOV DIMITAR L; ZARKADAS DIMITRIOS N
    权利人:SCHERING CORP
    摘要:The present invention relates to the compound of the formula n nTo methods of treating upper and lower obstructive airway diseases using said compound, to formulations comprising it, and to polymorphs and processes of synthesis of the polymorphic forms.

    专利号:US-2013035307-A1
    优先权日:2010-01-26
    标 题:Methods for treating or preventing the spread of cancer using semi-synthetic glycosaminoglycosan ethers
    发明人:PRESTWICH GLENN D; KENNEDY THOMAS P
    权利人:UNIV UTAH RES FOUND; PRESTWICH GLENN D; KENNEDY THOMAS P
    摘要:Described herein are methods for the treatment and prevention of tumor metastasis using alkylated and fluoroalkylated semi-synthetic glycosaminoglycan ethers (“SAGEsâ€?). The synthesis of sulfated alkylated and fluoroalkylated SAGEs is also described.

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    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    主要参考文献


    1: Jain S, Panyutin A, Liu N, Xiao C, Piñol RA, Pundir P, Girardet C, Butler AA, Dong X, Gavrilova O, Reitman ML. Melanotan II causes hypothermia in mice by activation of mast cells and stimulation of histamine 1 receptors. Am J Physiol Endocrinol Metab. 2018 May 29. doi: 10.1152/ajpendo.00024.2018. [Epub ahead of print] doi: 10.1016/j.pbb.2018.04.010. [Epub ahead of print] doi: 10.3389/fphar.2018.00038. eCollection 2018.
    6: Stoddart LA, Vernall AJ, Bouzo-Lorenzo M, Bosma R, Kooistra AJ, de Graaf C, Vischer HF, Leurs R, Briddon SJ, Kellam B, Hill SJ. Development of novel fluorescent histamine H(1)-receptor antagonists to study ligand-binding kinetics in living cells. Sci Rep. 2018 Jan 25;8(1):1572. doi: 10.1038/s41598-018-19714-2.
    7: Akanuma SI, Yamazaki Y, Kubo Y, Hosoya KI. Role of cationic drug-sensitive transport systems at the blood-cerebrospinal fluid barrier in para-tyramine elimination from rat brain. Fluids Barriers CNS. 2018 Jan 8;15(1):1. doi: 10.1186/s12987-017-0087-9.

    合成参考文献


    参考文献:10.1530/rep.1.00737
    摘要:Kobayashi D, Irokawa M, Maeda T, Tsuji A, Tamai I. Carnitine/organic cation transporter OCTN2-mediated transport of carnitine in primary-cultured epididymal epithelial cells. Reproduction. 2005 Dec;130(6):931–7. doi: 10.1530/rep.1.00737.
    参考文献:10.1007/s00424-011-0995-5
    摘要:López-Izquierdo A, Aréchiga-Figueroa IA, Moreno-Galindo EG, Ponce-Balbuena D, Rodríguez-Martínez M, Ferrer-Villada T, Rodríguez-Menchaca AA, van der Heyden MAG, Sánchez-Chapula JA. Mechanisms for Kir channel inhibition by quinacrine: acute pore block of Kir2.x channels and interference in PIP2 interaction with Kir2.x and Kir6.2 channels. Pflügers Archiv - European Journal of Physiology. 2011 Jul 22;462(4):505. doi: 10.1007/s00424-011-0995-5.
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