CAS: 87-08-1; Phenoxymethylpenicillin
该化合物是一种半合成抗生素,其活动范围广泛,可以对抗各种抗格伦阳性和某些格伦阴性细菌. 它提供了更高的生物利用率和长期的效益,使它成为治疗呼吸道,皮肤和软组织感染的首选选择. 它独特的药用植物基因特征在保持功效的同时最大限度地减少了副作用,为病人提供了可靠的治疗选择.
- 英文名称Phenoxymethylpenicillin
- 中文名称青霉素V
- IUPAC名称4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-((phenoxyacetyl)amino)-, (2S,5R,6R)-
- 其它别名(2s-(2alpha,5alpha,6beta))-enoxyacetyl)amino); 3,3-dimethyl-7-oxo-6-[(phenyloxyacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptan; 6-phenoxyacetamido-penicillanicaci; 6-phenoxyacetamidopenicillanicacid; acipenv; apopen; calcipen; comp°Cillinv
- CAS编号87-08-1
- MFCD编号:MFCD00070096
- EINECS号:201-722-0
- FDA UNII编号:Z61I075U2W
- 分子式:C16H18N2O5S分子量:350.39
- 产品CID: 2390036
- 产品分类原料药 → 抗生素类药物 → 青霉素类药
物理性质
- 熔点120 - 128 °C
- 沸点681.4±55.0 °C at 760 mmHg
- 闪点365.9±31.5 °C
- 密度1.5±0.1 g/cm3
- pKa:2.44±0.50(预测)
- PSA:121.24
- LogP:1.88
- 折射率1.651
- 蒸汽压0.0±2.2 mmHg at 25°C
- 溶解性Very Slightly Soluble In Water, Soluble In Ethanol (96 Per Cent).
- 敏感性Stable. Combustible. Incompatible with strong oxidizing agents.
- 外观形态固体
- 储存条件−20°C
- 产品应用该化合物是一种广泛频谱的青霉素抗生素抗生物,口服用于治疗易感染的克抗体生物的中度至轻度感染.
MSDS等安全信息
欧盟法规
ECHA物质ECHA物质C&L通报REACH预注册上下游产品
CAS号551-16-6 6-氨基青霉烷酸 | CAS号701-99-5 苯氧基乙酰氯 | CAS号65538-78-5 2-bromoethyl (2... | CAS号52-67-5 D-青霉胺 | CAS号1030-50-8 (4S)-2t-((R)-am... | CAS号1057-37-0 (4S)-2t-[(R)-te... | CAS号1056-69-5 (4S)-2t-((R)-te... | CAS号59168-65-9 2-[(1,3-dioxois... | CAS号551-16-6 6-氨基青霉烷酸 | CAS号122-59-8 苯氧乙酸 | CAS号2315-05-1 methyl 3,3-dime...合成工艺路线路线简述
- 2065-23-8 + 551-16-6 = 87-08-1
反应条件:1.1 Solvents: Water; Ph 7,30 °C
标题:Enzymatic Synthesis Of β-Lactam Antibiotics And N-Fatty-Acylated Amino Compounds By The Acyl-Transfer Reaction Catalyzed By Penicillin V Acylase From Streptomyces Mobaraensis
作者:Koreishi,Mayuko; Et Al
参考文献:Bioscience 日期:2007 卷标:71(6) 页码:1582-1586]
122-59-8 + 551-16-6 = 87-08-1
反应条件:1.1 Reagents: Isopenicillin N-Acyltransferase,Phenylacetyl-Coenzyme A Synthetase
标题:"In Vitro" Synthesis Of Different Naturally-Occurring,Semisynthetic And Synthetic Penicillins Using A New And Effective Enzymic Coupled System
作者:Martinez-Blanco,H.; Et Al
参考文献:Journal Of Antibiotics 日期:1991 卷标:44(11) 页码:1252-8]
50-99-7 = 87-08-1
反应条件:1.1 Solvents: Water; 220 H
标题:Analysis And Optimization Of Biochemical Process Reaction Pathways. 1. Pathway Sensitivities And Identification Of Limiting Steps
作者:Conejeros,Raul; Et Al
参考文献:Industrial & Engineering Chemistry Research 日期:1998 卷标:37(12) 页码:4699-4708]
= 87-08-1
反应条件:1.1 Reagents: L-Ascorbic Acid,Ethylenediaminetetraacetic Acid,Ferrous Sulfate,Oxygen Solvents: Dichloromethane,Water
标题:Biomimetic Synthesis Of Penicillin
作者:Baldwin,Jack E.; Et Al
参考文献:Journal Of The Chemical Society 日期:1985 卷标:(6) 页码:357-9]
= 87-08-1
反应条件:1.1 Reagents: L-Ascorbic Acid,Ethylenediaminetetraacetic Acid,Ferrous Sulfate,Hydrogen Peroxide Solvents: Dichloromethane,Water
标题:Biomimetic Synthesis Of Penicillin
作者:Baldwin,Jack E.; Et Al
参考文献:Journal Of The Chemical Society 日期:1985 卷标:(6) 页码:357-9]
= 87-08-1
反应条件:1.1 Reagents: Trifluoroacetic Acid Solvents: Benzene,Anisole2.1 Reagents: L-Ascorbic Acid,Ethylenediaminetetraacetic Acid,Ferrous Sulfate,Oxygen Solvents: Dichloromethane,Water
标题:Biomimetic Synthesis Of Penicillin
作者:Baldwin,Jack E.; Et Al
参考文献:Journal Of The Chemical Society 日期:1985 卷标:(6) 页码:357-9]
2065-23-8 + 551-16-6 = 87-08-1
反应条件:1.1 Reagents: Tris(Hydroxymethyl)Aminomethane Hydrochloride Catalysts: Penicillin Amidase Solvents: Dimethyl Sulfoxide,Water; 10.8 H,Ph 7,30 °C
标题:Kinetically Controlled Acylation Of 6-Apa Catalyzed By Penicillin Acylase From Streptomyces Lavendulae: Effect Of Reaction Conditions In The Enzymatic Synthesis Of Penicillin V
作者:Hormigo,Daniel; Et Al
参考文献:Biocatalysis And Biotransformation 日期:2020 卷标:38(4) 页码:253-262]
65538-78-5 = 87-08-1
反应条件:1.1 Reagents: Phenol Catalysts: Cobaltate(1-),[29H,31H-Phthalocyaninato(2-)-N29,N30,N31,N32]-,Lithium,(Sp-4-1... Solvents: Acetone
标题:Extremely Selective And Mild Cleavage Of β-Haloalkyl Groups By Cobalt(I) Phthalocyanine Anion In Semisyntheses Of β-Lactam Antibiotics
作者:Eckert,Heiner
参考文献:Zeitschrift Fuer Naturforschung 日期:1990 卷标:45(12) 页码:1715-24]
50-99-7 + 9005-25-8 + 56-81-5 + 63-42-3 = 87-08-1
反应条件:1.1 Solvents: Water; Ph 5.8,25 °C
标题:Execution Of Enriched Rice Bran Medium In Hyper Production Of Penicillin V By Penicillium Chrysogenum
作者:Parameswari,S.; Et Al
参考文献:Waste And Biomass Valorization 日期:2018 卷标:9(9) 页码:1559-1565]
= 87-08-1
反应条件:1.1 Reagents: Ceric Ammonium Nitrate Solvents: Acetonitrile,Water
标题:New Oxidatively Removable Carboxy Protecting Groups
作者:Kim,C. U.; Et Al
参考文献:Tetrahedron Letters 日期:1985 卷标:26(17) 页码:2027-30]
97227-10-6 = 87-08-1
反应条件:1.1 Reagents: Ceric Ammonium Nitrate Solvents: Acetonitrile,Water
标题:New Oxidatively Removable Carboxy Protecting Groups
作者:Kim,C. U.; Et Al
参考文献:Tetrahedron Letters 日期:1985 卷标:26(17) 页码:2027-30]
= 87-08-1
反应条件:1.1 Reagents: Trifluoroacetic Acid Solvents: Benzene,Anisole2.1 Reagents: L-Ascorbic Acid,Ethylenediaminetetraacetic Acid,Ferrous Sulfate,Hydrogen Peroxide Solvents: Dichloromethane,Water
标题:Biomimetic Synthesis Of Penicillin
作者:Baldwin,Jack E.; Et Al
参考文献:Journal Of The Chemical Society 日期:1985 卷标:(6) 页码:357-9]
= 87-08-1
反应条件:1.1 Reagents: Iodine2.1 Reagents: Trifluoroacetic Acid Solvents: Benzene,Anisole3.1 Reagents: L-Ascorbic Acid,Ethylenediaminetetraacetic Acid,Ferrous Sulfate,Hydrogen Peroxide Solvents: Dichloromethane,Water
标题:Biomimetic Synthesis Of Penicillin
作者:Baldwin,Jack E.; Et Al
参考文献:Journal Of The Chemical Society 日期:1985 卷标:(6) 页码:357-9]
= 87-08-1
反应条件:1.1 Reagents: Triethylamine,Phenoxyacetic Acid,2-Ethoxy-1-(Ethoxycarbonyl)-1,2-Dihydroquinoline2.1 Reagents: Iodine3.1 Reagents: Trifluoroacetic Acid Solvents: Benzene,Anisole4.1 Reagents: L-Ascorbic Acid,Ethylenediaminetetraacetic Acid,Ferrous Sulfate,Hydrogen Peroxide Solvents: Dichloromethane,Water
标题:Biomimetic Synthesis Of Penicillin
作者:Baldwin,Jack E.; Et Al
参考文献:Journal Of The Chemical Society 日期:1985 卷标:(6) 页码:357-9]
= 87-08-1 + 97748-56-6
反应条件:1.1 Reagents: L-Ascorbic Acid,Ethylenediaminetetraacetic Acid,Ferrous Sulfate,Oxygen Solvents: Dichloromethane,Water
标题:Biomimetic Synthesis Of Penicillin
作者:Baldwin,Jack E.; Et Al
参考文献:Journal Of The Chemical Society 日期:1985 卷标:(6) 页码:357-9]
= 87-08-1 + 97748-56-6
反应条件:1.1 Reagents: Trifluoroacetic Acid Solvents: Benzene,Anisole2.1 Reagents: L-Ascorbic Acid,Ethylenediaminetetraacetic Acid,Ferrous Sulfate,Oxygen Solvents: Dichloromethane,Water
标题:Biomimetic Synthesis Of Penicillin
作者:Baldwin,Jack E.; Et Al
参考文献:Journal Of The Chemical Society 日期:1985 卷标:(6) 页码:357-9]
= 87-08-1 + 97748-56-6
反应条件:1.1 Reagents: Iodine2.1 Reagents: Trifluoroacetic Acid Solvents: Benzene,Anisole3.1 Reagents: L-Ascorbic Acid,Ethylenediaminetetraacetic Acid,Ferrous Sulfate,Oxygen Solvents: Dichloromethane,Water
标题:Biomimetic Synthesis Of Penicillin
作者:Baldwin,Jack E.; Et Al
参考文献:Journal Of The Chemical Society 日期:1985 卷标:(6) 页码:357-9
📜6-氨基青霉烷酸 以 氯仿 作为反应溶剂,化学反应生成 青霉素v
参考文献:Glombitza,K.-W.,Justus Liebigs Annalen Der Chemie,1964,Vol. 673,P. 166-170
标题:Glombitza,K.-W.,Justus Liebigs Annalen Der Chemie,1964,Vol. 673,P. 166-170
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专利信息
专利号:US-2024197774-A1
优先权日:2021-04-16
标 题:Synthesis of Antimicrobial PVP-coated Bismuth Nanoparticles
发明人：LOPEZ-RIBOT JOSE; VAZQUEZ-MUNOZ ROBERTO
权利人:UNIV TEXAS
摘要:Described herein is a facile, fast, and economical method for the synthesis of BAL-mediated PVP-BiNPs, using basic laboratory instruments and reagents readily available in most laboratories.
专利号:US-11311505-B2
优先权日:2017-02-24
标 题:Synergistic compositions to stimulate the synthesis of human lung and sinus surfactants to decrease coughing, increase FEV-1/FVC ratios, decrease lung fibrosis, by increasing apoptosis of myofibroblasts
发明人：MARTIN ALAIN
权利人:MARTIN ALAIN; CELLULAR SCIENCES INC
摘要:Methods for the treatment of patients with both Chronic Obstructive Pulmonary Disease (COPD) and pulmonary fibrosis, and of patients with idiopathic pulmonary fibrosis without COPD, by stimulating the synthesis of human and animal patient lung and sinus surfactants to increase lung functions, inhibiting fibrosis and reducing coughing and nasal erythema, include the following steps: A) analyzing and diagnosing a patient with a lung ailment selected from the group consisting of i) both COPD and pulmonary fibrosis; and ii) idiopathic pulmonary fibrosis without COPD; and, B) treating the patient to raise the patient's lung functions including FEV1/FVC ratio by contacting mammalian cells with a [therapeutically effective amount of a treatment] composition that includes: a) a pyruvate salt; b) a phosphate; c) a salt of calcium; and d) a salt of magnesium, in an aqueous carrier, containing no more than 2.2 grams of said pyruvate salt per liter.
专利号:US-11744867-B2
优先权日:2017-02-14
标 题 :Modulation of microbial synthesis of 4-ethylphenol and 4-ethylphenyl sulfate in behavior and disease
发明人：NEEDHAM BRITTANY D; MAZMANIAN SARKIS K; SHARON GIL; FUNABASHI MASANORI; FISCHBACH MICHAEL A; HSIAO ELAINE Y; PATTERSON PAUL H
权利人:CALIFORNIA INST OF TECHN; UNIV CALIFORNIA
摘要:Some embodiments relate to genetically engineered bacterial strains for modulation of levels of the bacterial metabolite 4-ethylphenol (4EP) and its sulfated form, 4-ethylphenyl sulfate (4EPS). In some embodiments, the bacteria reduce or inhibit production of 4EP or 4EPS in the gut of a subject. The bacteria can ameliorate, delay the onset, or reduce the likelihood of one or more symptoms associated with anxiety and/or autism spectrum disorder (ASD) in the subject.
专利号:US-2005186197-A1
优先权日:2002-08-29
标 题:Peptide inhibitors of beta lactamases
发明人：PALZKILL TIMOTHY; HUANG WANZHI
摘要:Peptide inhibitors of β-lactamases have been identified by the synthesis of peptide arrays using synthesis SPOT technology. These peptide inhibitors of β-lactamase have activity against a broad spectrum of β-lactamases and are useful in a variety of applications.
专利号:US-10813893-B2
优先权日:2017-02-24
标 题:Compositions and methods for the treatment and prevention of chronic hypoxemia and dyspnea
发明人：MARTIN ALAIN
权利人:MARTIN ALAIN; CELLULAR SCIENCES INC
摘要:The present invention has shown that not all salts of pyruvic acid enhance lung functions or enhance the synthesis of lung surfactants and that certain salts of pyruvic acid with the correct concentrations of calcium, phosphate and magnesium, are synergistic in their ability to enhance the synthesis of lung surfactants that will enhance lung alveoli functions, while decreasing coughing and lung tightness, and increasing oxygen saturation values to prevent hypoxemia. This patent demonstrates that the sodium pyruvate formula with calcium, phosphate and magnesium was superior over standard sodium pyruvate formula in saline alone in the removal of mucus, reduction of lung or sinus infections, and in reducing drug side effects and congestion. The use of this formula clearly demonstrated that it can be used to produce better efficacy in patients with hypoxemia, with lung and sinus diseases including, asthma, COPD, cystic fibrosis, interstitial lung disease, allergic rhinitis, sinusitis, Alzheimer's, disease, Parkinson's disease, brain trauma, nicotine addiction, sleep apnea, autism, migraine headaches, sleep disorders, lung and sinus infections, cancer therapy with cancer drugs, nicotine addiction, and medications that cause a decrease in lung surfactants.
专利号:US-8557979-B2
优先权日:2004-06-10
标题 :Carbapenem antibacterials with gram-negative activity and processes for their preparation
发明人：CHOI WOO-BAEG; KOWALIK EWA
权利人:CHOI WOO-BAEG; KOWALIK EWA; FOB SYNTHESIS INC
摘要:The present invention provides β-methyl carbapenem compounds and pharmaceutical compositions useful in the treatment of bacterial infections and methods for treating such infections using such compounds and/or compositions. The invention includes administering an effective amount of a carbapenem compound or salt and/or prodrug thereof to a host in need of such a treatment. The present invention is also in the field of synthetic organic chemistry and is specifically provides an improved method of synthesis of β-methyl carbapenems which are useful as antibacterial agents.
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品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: Rasmussen HC, Hanberg P, Lilleøre JG, Petersen EK, Hvistendahl MA, Jørgensen AR, Stilling M, Bue M. Penicillin concentrations in bone and subcutaneous tissue: A porcine microdialysis study comparing oral and intravenous treatment. J Orthop Res. 2024 Aug 5. doi: 10.1002/jor.25947. Epub ahead of print.
8:265-269. doi: 10.5414/ALX02508E.
3: Hanberg P, Rasmussen HC, Bue M, Stilling M, Jørgensen AR, Petersen EK, Lilleøre JG, Hvistendahl MA, Bille J, Klug TE. Penicillin concentrations in oropharyngeal and frontal sinus tissue following enteral and intravenous administration measured by microdialysis in a porcine model. Eur J Pharm Sci. 2024 Jul 20;201:106859. doi: 10.1016/j.ejps.2024.106859. Epub ahead of print. 14(1):16762. doi: 10.1038/s41598-024-67354-6.
合成参考文献
合成方法参考DOI号:10.1080/10242422.2019.1652274
📝 需求与反馈
尽可能描述清楚需求与问题信息
