CAS: 76903-88-3; 3,4-Difluorobenzoylchloride

该化合物是一种芳烃氯化物,其特点是在苯环的3和4个位置上有两个氟原子,加上碳基(C=O)和碳基碳基的氯原子(Cl),该化合物一般是无色的,淡黄色的,有刺青味的黄色液体,表明其反应性;众所周知,该化合物在有机合成中具有燃气剂的作用,特别是在准备各种氟化合物和药品时.氟原子的存在会增强它的电子生殖性,使其在化学反应中成为有用的中间体.3,4-二氟苯基氯对湿气敏感,因此可以水化形成相应的碳酸,因此应在水性条件下加以处理.在使用该化合物时,由于其腐蚀性且在接触皮肤或粘膜时可能会引起刺激,安全防范是不可或缺的.

英文名称3,4-Difluorobenzoylchloride
中文名称3,4-二氟苯甲酰氯
IUPAC名称3,4-difluorobenzoyl chloride
其它别名3,4-Difluoro Benzoyl Chloride; Benzoyl Chloride, 3,4-Difluoro-; 3,4-Difluorobezoyl Chloride; 3,4-Diflourobenzoyl Chloride; 3,4-Difluorobenzoylchloride; 3,4-Difluorobenzoyl Chloride
CAS编号76903-88-3
MFCD编号:MFCD00009930
EINECS号:278-570-7
分子式:C7H3ClF2O
分子量:176.55
产品CID: 1761374
产品分类有机原料→分子砌块→芳环类化合物→苯类化合物

相似结构搜索
InChIKey: RPQWXGVZELKOEU-UHFFFAOYSA-N
InChI=1S/C7H3ClF2O/c8-7(11)4-1-2-5(9)6(10)3-4/h1-3H…
计算化学: 氢键受体数3.0氢键供体数0.0可旋转键数1.0

MSDS等安全信息

GHS象形图
GHS符号GHS05;
注释: Corrosion
危险类别皮肤腐蚀类别1B
严重眼损伤类别1
金属腐蚀物类别1
皮肤腐蚀类别1C
特定目标器官毒性 - 单次接触类别3
严重眼刺激类别2
警示词Danger(危险)
危险描述H314 |造成严重皮肤灼伤和眼损伤.
H318 |造成严重眼损伤.
H290 |可能对金属造成腐蚀.
H335 |可能引起呼吸道刺激.
H319 |造成严重眼刺激.
防范说明P260-P264-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P363-P405-P501
危险等级8
UN编号3265.0
危险品标志C
风险等级Corrosive
包装等级Ⅱ
安全声明26-36/37/39-45
危险类别码34
WGK Germany3

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

合成工艺路线路线简述

4-氯三氯甲苯置于potassium Fluoride,Sodium Hydroxide,氯化亚砜,Chlorosulphuric Acid,四苯基溴化膦体系中,用环丁砜,甲苯,乙腈,苯作为反应溶剂,120.0~210.0 °C,36.0 Kpa 条件下,反应 28.0H,反应生成 3,4-二氟苯甲酰氯
参考文献:氟化钾交换法通用高效合成间氟芳烃
标题:氟化钾交换法通用高效合成间氟芳烃
摘要:发现四苯基溴化鏻是一种合适的催化剂,用于在化学计量量的邻苯二甲酰氯存在下,使带有氰基,硝基,氯羰基,三氟甲基和氯磺酰基的间硝基芳基衍生物与氟化钾反应,得到相应的间氟芳烃衍生品收益非常好.还发现该催化剂通过使用反应蒸馏技术对间(氟磺酰基)芳基衍生物进行氟脱磺酰化以提供间氟芳烃是有效的.
DOI:10.1246/bcsj.63.2010

海关参考信息

2912110000-甲醛
2912210000-苯甲醛
2903110000-一氯甲烷及氯乙烷
💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
详情请参考：📖 海关编码查询和海关进出口税则

专利信息

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优先权日:2004-04-20
标题:Synthesis of COX-2 and FAAH inhibitors
发明人：BARTOLINI WILMIN; CALI BRIAN M; CHEN BARBARA; CHIEN YUEH-TYNG; CURRIE MARK G; MILNE G T; PEARSON JAMES P; TALLEY JOHN J; ZIMMERMAN CRAIG
权利人:BARTOLINI WILMIN; CALI BRIAN M; CHEN BARBARA; CHIEN YUEH-TYNG; CURRIE MARK G; MILNE G T; PEARSON JAMES P; TALLEY JOHN J; ZIMMERMAN CRAIG
摘要:Methods for preparing indoles that are useful COX-2 inhibitors and intermediates useful in such methods are described.

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专利号:US-6080760-A
优先权日:1997-06-18
标题:Alpha 1A adrenergic receptor antagonists
发明人：PATANE MICHAEL A; BOCK MARK G
权利人:MERCK & CO INC
摘要:This invention relates to certain novel compounds and derivatives thereof, their synthesis, and their use as alpha 1a adrenergic receptor antagonists. One application of these compounds is in the treatment of benign prostatic hyperplasia. These compounds are selective in their ability to relax smooth muscle tissue enriched in the alpha 1a receptor subtype without at the same time inducing hypotension. One such tissue is found surrounding the urethral lining. Therefore, one utility of the instant compounds is to provide acute relief to males suffering from benign prostatic hyperplasia, by permitting less hindered urine flow. Another utility of the instant compounds is provided by combination with a human 5-alpha reductase inhibitory compound, such that both acute and chronic relief from the effects of benign prostatic hyperplasia are achieved.