CAS: 7250-67-1; 1-(2-Chloroethyl)Pyrrolidine Hydrochloride

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5050-41-9 57616-69-0 39743-20-9

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CAS号123-75-1 四氢吡咯 | CAS号107-07-3 2-氯乙醇 | CAS号2955-88-6 N-羟乙基吡咯烷 | CAS号107752-02-3 1-(4-pyrrolidin... | CAS号50609-01-3 4-[2-(吡咯烷-1-基)乙氧基]苯胺 | CAS号5050-41-9 1-(2-氯乙基)吡咯烷 | CAS号1845-11-0 萘福昔定 | CAS号262451-89-8 SC 22716 | CAS号26116-47-2 4-(2-pyrrolidin... | CAS号265654-77-1 1-(2-(4-硝基苯氧基)乙基)吡咯烷 | CAS号2955-88-6 N-羟乙基吡咯烷 | CAS号7154-73-6 1-(2-氨乙基)吡咯烷

N-(2-羟乙基)-吡咯烷置于氯化亚砜体系中,用 氯仿 作为反应溶剂,化学反应生成 N-(2-氯乙基)吡咯烷盐酸盐
参考文献:侧链对叔胺官能化多肽的ph和热响应性的影响
标题:侧链对叔胺官能化多肽的ph和热响应性的影响
摘要:侧链上的ph的结构影响的系统调查和叔胺官能化聚(热响应性升-谷氨酸)s(ta-的pgs)中的溶液中进行.通过铜(i)催化的叠氮基叔胺与聚(γ-炔丙基-L-谷氨酸)(pplg)的叠氮化物-炔烃环加成点击反应有效合成了ta-Pgs聚合物.进行了比浊法测量,以表征ta-Pg在水溶液中的ph和温度诱导的相变,这表明该性质对氮的结构依赖性取代基团和1,2,3-三唑环与侧链中叔胺基团之间的"连接基".详细地讲,Ta-Pg的ph响应特性基本上由侧链中n-取代基团的疏水性决定,Ph转变点(ph T)随着n-取代基团疏水性的增加而降低,而ta Pg的温度响应性受n取代基或"连接基"的影响.具有中等n取代胺基(例如dea,Pr和pd)或支链"连接子"(例如iso-丙烯和2-甲基丙烯基)更可能表达因ph值变化而调整的lcst型相变.这项研究揭示的这些结构-属性关系将有助于开发ta-Pg在智能药物输送系统中的应用.©2013
DOI:10.1002/pola.27048

专利信息

专利号:US-8399502-B2
优先权日:2008-09-17
标 题 :Analogs of indole-3-carbinol and their use as agents against infection
发明人：JONG LING; JIANG FAMING; LI GAOQUAN; MORTELMANS KRISTIEN
权利人:JONG LING; JIANG FAMING; LI GAOQUAN; MORTELMANS KRISTIEN; STANFORD RES INST INT
摘要:Compounds useful as antibacterial agents are provided. The compounds are analogs of indole-3-carbinol and have a backbone selected from dihydroindolo[2,3-b]carbazole, 2,2′-diindolylmethane, 2′,3-diindolylmethane, and 3,3′-diindolylmethane. The compounds are useful therapeutic and prophylactic treatment of bacterial infections in mammals. Methods of synthesis of the compounds are provided, as are pharmaceutical compositions containing the compounds.

专利号:US-7582653-B2
优先权日:2003-03-31
标 题 :Mercaptophenyl naphthyl methane compounds and synthesis thereof
权利人:COUNCIL SCIENT IND RES
摘要:Novel mercaptophenyl naphthyl methane compounds, their pharmaceutically acceptable salts and compositions comprised thereof are useful for the prevention or treatment of various medical indications associated with estrogen dependent diseases or syndromes related to osteoporosis, bone loss, bone formation, cardiovascular disorders, neurodegenerative disorders, menopausal disorders, physiological disorders, diabetes disorders, prostatic carcinoma, cancer of breast, cancer of uterus, cancer of the cervix and cancer of the colon, threatened or habitual abortion, obesity, ovarian development or function, post-partum lactation and depression.

专利号:US-9481660-B2
优先权日:2006-10-02
标题 :Tetra-O-substituted butane-bridge modified NDGA derivatives, their synthesis and pharmaceutical use
发明人：HELLER JONATHAN DANIEL; CHEN QINGQI; LOPEZ ROCIO ALEJANDRA; MORRIS AMANDA JEAN
权利人:HELLER JONATHAN DANIEL; CHEN QINGQI; LOPEZ ROCIO ALEJANDRA; MORRIS AMANDA JEAN; ERIMOS PHARMACEUTICALS LLC
摘要:The present invention relates to nordihydroguaiaretic acid derivative compounds, namely, butane bridge modified nordihydroguaiaretic acid (NDGA) compounds and butane bridge modified tetra-O-substituted NDGA compounds, pharmaceutical compositions containing them, methods of making them, and methods of using them and kits including them for the treatment of diseases and disorders, in particular, diseases resulting from or associated with a virus infection, such as HIV infection, HPV infection, or HSV infection, an inflammatory disease, such as various types of arthritis and inflammatory bowel diseases, metabolic diseases, such as diabetes and hypertension, or a proliferative disease, such as diverse types of cancers.

专利号:US-8178527-B2
优先权日:2006-10-02
标 题 :Tetra-substituted NDGA derivatives via ether bonds and carbamate bonds and their synthesis and pharmaceutical use
发明人：CHEN QINGQI; LOPEZ ROCIO ALEJANDRA; HELLER JONATHAN DANIEL; MORRIS AMANDA JEAN
权利人:CHEN QINGQI; LOPEZ ROCIO ALEJANDRA; HELLER JONATHAN DANIEL; MORRIS AMANDA JEAN; ERIMOS PHARMACEUTICALS LLC
摘要:Disclosed are nordihydroguaiaretic acid derivative compounds including various end groups bonded by a carbon atom or heteroatom though a side chain bonded to the respective hydroxy residue O groups by an ether bond or a carbamate bond, pharmaceutical compositions, methods of making them, and methods of using them and kits including them for the treatment of diseases and disorders, in particular, diseases resulting from or associated with a virus infection, such as HIV infection, HPV infection, or HSV infection, an inflammatory disease, such as various types of arthritis and inflammatory bowel diseases, a metabolic disease, such as diabetes, a vascular disease, such as hypertension and macular degeneration, or a proliferative disease, such as diverse types of cancers.

专利号:US-9067875-B2
优先权日:2006-10-02
标 题 :Tetra-substituted NDGA derivatives via ether bonds and carbamate bonds and their synthesis and pharmaceutical use
发明人：CHEN QINGQI; LOPEZ ROCIO ALEJANDRA; HELLER JONATHAN DANIEL; MORRIS AMANDA JEAN
权利人:CHEN QINGQI; LOPEZ ROCIO ALEJANDRA; HELLER JONATHAN DANIEL; MORRIS AMANDA JEAN; ERIMOS PHARMACEUTICALS LLC
摘要:Disclosed are nordihydroguaiaretic acid derivative compounds including various end groups bonded by a carbon atom or heteroatom though a side chain bonded to the respective hydroxy residue O groups by an ether bond or a carbamate bond, pharmaceutical compositions, methods of making them, and methods of using them and kits including them for the treatment of diseases and disorders, in particular, diseases resulting from or associated with a virus infection, such as HIV infection, HPV infection, or HSV infection, an inflammatory disease, such as various types of arthritis and inflammatory bowel diseases, a metabolic disease, such as diabetes, a vascular disease, such as hypertension and macular degeneration, or a proliferative disease, such as diverse types of cancers.

专利号:US-8785632-B2
优先权日:2004-08-26
标 题:Enantiomerically pure aminoheteroaryl compounds as protein kinase inhibitors
发明人：CUI JINGRONG JEAN; FUNK LEE ANDREW; JIA LEI; KUNG PEI-PEI; MENG JERRY JIALUN; NAMBU MITCHELL DAVID; PAIRISH MASON ALAN; SHEN HONG; TRAN-DUBE MICHELLE
权利人:CUI JINGRONG JEAN; FUNK LEE ANDREW; JIA LEI; KUNG PEI-PEI; MENG JERRY JIALUN; NAMBU MITCHELL DAVID; PAIRISH MASON ALAN; SHEN HONG; TRAN-DUBE MICHELLE; AGOURON PHARMA; PFIZER
摘要:Enantiomerically pure compound of formula 1 n nare provided, as well as methods for their synthesis and use. Preferred compounds are potent inhibitors of the c-Met protein kinase, and are useful in the treatment of abnormal cell growth disorders, such as cancers.