CAS: 701-97-3; 3-Cyclohexylpropionic Acid

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CAS号501-52-0 3-苯丙酸 | CAS号1124-63-6 3-环己基-1-丙醇 | CAS号7400-08-0 对羟基肉桂酸 | CAS号2033-24-1 丙二酸环(亚)异丙酯 | CAS号2043-61-0 环己烷甲醛 | CAS号140-10-3 肉桂酸 | CAS号97865-17-3 2,2,2-trichloro... | CAS号701-98-4 β-cyclohexylide... | CAS号621-82-9 肉桂酸 | CAS号4287-98-3 β-phenyl-β-prop... | CAS号39098-75-4 3-环己基丙酰氯 | CAS号145439-79-8 2-iodo-3-cycloh... | CAS号4442-85-7 2-环己基乙胺 | CAS号4361-28-8 Cyclohexanepropanal | CAS号1124-63-6 3-环己基-1-丙醇 | CAS号34094-21-8 3-环己基-1-溴丙烷 | CAS号20681-51-0 3-环己基丙酸甲酯 | CAS号10094-36-7 3-环己基丙酸乙酯 | CAS号699-61-6 1-氧杂螺[4.5]癸-2-酮 | CAS号80203-35-6 2-CYCLOHEXYL-1-...

肉桂醛置于silver-Graphite,氧气,Sodium Hydroxide,Ruthenium-Carbon Composite,氢气,硫酸体系中,用 水 作为反应溶剂,40.0~125.0 °C,2.0 Mpa 条件下,反应 7.5H,以92.5%的收率获得产物3-环己基丙酸
参考文献:一种3-环己基丙酸的合成方法
标题:一种3-环己基丙酸的合成方法
摘要:一种3‑环己基丙酸的合成方法,涉及3‑环己基丙酸.在碱性溶液中,加入银碳催化剂,再加入肉桂醛,氧化反应后,过滤出银碳催化剂,滤液为肉桂酸盐混合溶液;将肉桂酸盐混合溶液转移到氢化反应釜中,在釕碳催化剂催化下,通入氢气,加热进行氢化反应后,过滤出釕碳催化剂,滤液用酸酸化至ph=2~3,静置分层后,得到3‑环己基丙酸.用肉桂醛氧化反应液,没有经过后处理,直接用于氢化反应,得到3‑环己基丙酸,总得率可为90%以上.将氧化反应后得到的反应液,不需要经过酸化,洗涤,脱色,提纯等处理,而是直接利用氧化反应液,通过加氢技术实现3‑环己基丙酸的合成新工艺方法,明显节省3‑环己基丙酸的合成成本.

专利信息

专利号:US-7276637-B2
优先权日:2002-08-02
标题:Synthesis of cyclohexanone derivatives
发明人：BRANDS KAREL MARIE JOSEPH; DAVIES ANTONY JOHN; OAKLEY PAUL JOSEPH; SCOTT JEREMY PETER; SHAW DUNCAN EDWARD; TEALL MARTIN RICHARD
权利人:MERCK & CO INC
摘要:A novel process for preparing cyclohexanone derivatives of formula (I) n nis described. The products are useful as gamma secretase inhibitors, or as intermediates in the synthesis of other gamma secretase inhibitors.

专利号:US-6177572-B1
优先权日:1997-08-20
标题 :Solid and liquid-phase synthesis of benzoxazoles and benzothiazoles and their use
发明人：WANG FENGJIANG
权利人:SEPRACOR INC
摘要:Methods for preparing benzoxazoles and benzothiazoles on solid supports. Substituted benzothiazoles and benzoxazoles, libraries of the compounds, and methods of using the compounds are also disclosed.

专利号:US-4661626-A
优先权日:1985-03-11
标题 :Process for the production of 2-isocyanato-2,3-dehydrocarboxylic acid esters
发明人：EFFENBERGER FRANZ; KUEHLWEIN JUERGEN; DRAUZ KARLHEINZ
权利人:DEGUSSA
摘要:There are produced 2-isocyanato-2,3-dehydrocarboxylic acid esters of the general formula: (I) in which R1 is a straight chain or branched C1-C4-alkyl group, a phenyl group or a benzyl group, R2 is hydrogen or a methyl group and R3 is hydrogen, a straight chain or branched C1-C16-alkyl group, a C3-C8-cycloalkyl group, a C1-C6-alkylmercapto group or a phenyl group by reacting a 2-azido-carboxylic acid ester of the general formula: (II) in an inert solvent at a temperature between 0 DEG and 150 DEG C. with phosgene or diphosgene in the presence of a perrhenate. The compounds of general formula (I) can be converted into the corresponding Z- or BOC-protected 2,3-dehydro-2-amino-carboxylic acid ester with benzyl alcohol or with tert. butyl alcohol, which esters in turn are valuable building blocks for the synthesis of dehydropeptides.

专利号:US-7411088-B2
优先权日:2004-02-20
标 题:Stereoselective synthesis of a 4,4-disubstituted cyclohexanepropanoic acid
发明人：BRANDS KAREL MARIE JOSEPH; BREWER SARAH ELIZABETH; DAVIES ANTONY JOHN; DOLLING ULF H; HAMMOND DEBORAH CAMILLE; LIEBERMAN DAVID ROSS; SCOTT JEREMY PETER
权利人:MERCK & CO INC; MERCK SHARP & DOHME
摘要:There is provided stereoselective route to a compound of formula I: n nwherein R represents H or an alkali metal, Ar 1 represents 4-chlorophenyl and Ar 2 represents 2,5-difluorophenyl.

专利号:US-3962217-A
优先权日:1969-10-24
标 题 :Process for the manufacture of Δ16 -steroid-14β,18,20-triols and -14β,20-diol-18-ols of the pregnane series
发明人：WEHRLI HANSULI; JEGER OSKAR
权利人:CIBA GEIGY CORP
摘要:The invention is for a selective reduction of the 20- oxo group in Δ 16 -steroid-14β,18-diol-20-ones of the pregnane series to form the two epimeric 20-alcohols having the 20 S and 20 R configuration. The process is especially intended for the manufacture of alkaloids of the batrachotoxin type, particularly for batrachotoxinine A, which is a pregnane derivative having a 20 S alcohol grouping, and epimers and derivatives, such as epi-batrachotixinine A or 7,8-dihydrobatrachotoxinine A. The process is characterized by reducing the said Δ 16 -steroid-14β,18-diol-20-ones in form of their 14,18-ketals, for instance the 14,18 acetonides and using appropriate complex light metal hydrides and operating at appropriate temperatures. The separation of the two isomers is easy and can be effected by the usual physical operations, such as crystallization or chromatography. In the 14β,18,20-triols obtained the 18-hydroxy group can be dehydrogenated to the corresponding 18-aldehydes, which are intermediates necessary in the synthesis of the said pharmacological interesting substances, such as batrachotoxin, by treatment with a sulphoxide in the presence of a carboxylic acid anhydride.

专利号:US-6664282-B2
优先权日:1999-09-17
标 题:Synthesis of [3,5,7]-1H-imidazo [1,5-a]imidazol-2 (3H)- one compounds
发明人：ELABDELLAOUI HASSAN M; OSTRESH JOHN M; HOUGHTEN RICHARD A
权利人:TORREY PINES INST
摘要:Individual substituted [3,5,7]-1H-imidazo[1,5-a]imidazol-2(3H)-one compounds and their pharmaceutically-acceptable salts are disclosed, as are libraries of such compounds. Methods of preparing and using the libraries of compounds as well as individual compounds of the libraries are also disclosed.