CAS: 68123-33-1; 2,5-Dioxopyrrolidin-1-Yl 2-(4-Nitrophenyl)Acetate

该化合物是一种反应性很强的乙酰剂,通常用于生物同化和peptide合成,其主要优点包括能够在温和条件下有效改变初级胺,使其对蛋白,peptides和其他生物分子具有价值,N-HIS和4-notrocentyente酯组的存在增强了其再活动性和选择性,使受控和稳定的氨联结形成. SNA在需要高当量衍生物的应用方面特别有用,例如近亲标签和探测合成.SNA在有机溶剂方面的稳定性和与水缓冲的兼容性进一步有助于其在生物化学和生物技术研究中的多用途.

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MSDS等安全信息

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CAS号6066-82-6 N-羟基琥珀酰亚胺 | CAS号50434-36-1 2-(4-硝基苯基)乙酰氯 | CAS号104-03-0 对硝基苯乙酸 | CAS号1814-64-8 LY-165,163 | CAS号118249-07-3 1-(2-(3-iodo-4-... | CAS号118249-08-4 1-(2-(3-iodo-4-...

合成工艺路线路线简述

    📜N-羟基丁二酰亚胺,2-(4-硝基苯基)乙酰氯置于三乙胺体系中,用 二氯甲烷 作为反应溶剂,化学反应生成 N-(4-硝基苯基乙酰氧基)琥珀酰亚铵
    参考文献: Potassium Ion Channel Modulators & Uses Thereof[fr] Modulateurs Des Canaux D'Ions Du Potassium Et Utilisations Associées
    标题: Potassium Ion Channel Modulators & Uses Thereof[fr] Modulateurs Des Canaux D'Ions Du Potassium Et Utilisations Associées
    摘要:化合物公式(i)及其药学上可接受的盐和前药,其中:Ar1和ar2是芳基或杂芳基;a为0至5;r1为烷基,卤素,卤代烷基,烷氧基,卤代烷氧基,烷氧羰基,羧基,羟基,氨基,单烷基氨基,双烷基氨基,硝基,酰胺基,烷氧羰基胺基,烷基磺酰基,烷基磺酰胺基或氰基,当a大于1时,每个取代基r1可以相同或不同;b为0至5;r2为烷基,卤素,卤代烷基,卤代烷氧基,烷氧基,烷氧羰基,羧基,羟基,氨基,单烷基氨基,双烷基氨基,硝基,酰胺基,烷氧羰基胺基,烷基磺酰基,烷基磺酰胺基或氰基,当b大于1时,每个取代基r2可以相同或不同;v从以下群组中选择:(cr3Ar3B)pcon(r3B)x和(cr3Ar3B)pn(r3B)co(x),其中所述群组在取代基z的3-(meta)或4-(para)位置上选择;w从以下群组中选择:Nr4A,O,S,S=o,So2和c(r4Ar4B)2;x为氢,烷基,羟基烷基,烷氧基烷基,卤代烷氧基烷基,芳氧基烷基,环烷基,芳基,杂芳基,多烷基氧基乙烯,氨基烷基,单烷基氨基烷基,双烷基氨基烷基,烷基,该烷基被公式nr8R9的基团取代,其中r8和r9与它们所连接的氮原子形成饱和或部分不饱和的杂环基团,羧基烷基,烷氧羰基烷基,卤代烷氧羰基烷基或芳基氧羰基烷基;y和z相同或不同,每个都是从以下取代基中选择:(cr5Ar5B)n1,C=o,So2,C(=o)nr5A;c(=o)nr5Aso2和c=o(r5Ar5B)n2;r3A,R3B,R4A,R4B,R5A和r5B相同或不同,每个都是从氢,烷基,环烷基,芳基和杂芳基中选择;n1和n2相同或不同,每个为0至2;p为0至2;是钾离子通道调节剂,使它们在治疗和预防疼痛,下尿路障碍等疾病方面特别有用.

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    专利信息


    专利号:US-5521179-A
    优先权日:1991-04-18
    标题 :Heterocyclic amides
    发明人：BERNSTEIN PETER R; SHAW ANDREW; THOMAS ROYSTON M; WARNER PETER; WOLANIN DONALD J
    权利人:ZENECA LTD
    摘要:The present invention relates to certain novel heterocyclic amides which are 1-pyridylacetamide compounds of formula I, set out herein, which are inhibitors of human leukocyte elastase (HLE), also known as human neutrophil elastase (HNE), making them useful whenever such inhibition is desired, such as for research tools in pharmacological, diagnostic and related studies and in the treatment of diseases in mammals in which HLE is implicated. The invention also includes intermediates useful in the synthesis of these heterocyclic amides, processes for preparing the heterocyclic amides, pharmaceutical compositions containing such heterocyclic amides and methods for their use.

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    主要参考文献

    参考标题:Synthesis Of Imidazo[1,2-A]Pyrazin-4-Ium Salts For The Synthesis Of 1,4,7-Triazacyclononane (Tacn) And N- And/or C-Functionalized Derivatives Thereof
    摘要:The Present Invention Embodiments Relate To A Compound With Formula (V′) The Invention Also Relates In Certain Embodiments To The Synthesis Method For Compound (V′) And Its Use For The Preparation Of 1,4,7-Triazacyclononane (Tacn) And N- And/or C-Functionalized Derivatives Thereof, Particularly Compounds With Formula (I) The Invention Also Relates In Certain Embodiments To Metallic Complexes Comprising A Ligand With Formula (I) And A Metal And Their Use For Imaging.

    合成参考文献


    参考文献:10.1007/s11419-019-00511-z
    摘要:Tsumura Y, Kiguchi A, Komatsuzaki S, Ieuji K. A novel method to distinguish β-methylphenylethylamines from isomeric α-methylphenylethylamines by liquid chromatography coupled to electrospray ionization mass spectrometry. Forensic Toxicology. 2019 Dec 11;38(2):465–74. doi: 10.1007/s11419-019-00511-z.
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