CAS: 6590-91-6; 1-(2,6-Dichlorophenyl)Thiourea

该化合物是有机化合物,其特征是二氯苯基协会内存在硫尿素功能组,一般是白色至白色晶状固体,以其各种化学反应和应用作用著称,特别是在药用化学领域和作为有机合成的试剂;在水和酒精等极溶剂中表现出中等溶解性,而非极溶剂中则不那么易溶解;在苯基环内存在氯原子,会增强其再活动性并影响其生物活动;2,6-二氯苯基尿素a经常因其潜在的药理特性,包括对酶抑制作用及其在农用化学品开发中的作用而得到研究;与许多硫素衍生物一样,它可能表现出毒性,在实验室使用期间需要谨慎处理和采取适当的安全措施.

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上下游产品

CAS号41542-10-3 N-[(2,6-dichlor... | CAS号540-72-7 硫氰酸钠 | CAS号608-31-1 2,6-二氯苯胺 | CAS号6590-95-0 2,6-二氯苯基异硫氰酸酯 | CAS号33663-43-3 2,6-dichloroani... | CAS号82636-21-3 ethyl 1-(2,6-di...

合成工艺路线路线简述

    📜2,6-二氯异硫氰酸苯酯置于氨体系中,用 甲醇 作为反应溶剂,化学反应 12.0H,反应生成 2,6-二氯苯基硫脲
    参考文献:Synthesis Of Thiophene-2-Carboxamidines Containing 2-Amino-Thiazoles And Their Biological Evaluation As Urokinase Inhibitors
    标题:Synthesis Of Thiophene-2-Carboxamidines Containing 2-Amino-Thiazoles And Their Biological Evaluation As Urokinase Inhibitors
    摘要:The Serine Protease Urokinase (Upa) Has Been Implicated In The Progression Of Both Breast And Prostate Cancer. Utilizing Structure Based Design,The Synthesis Of A Series Of Substituted 4-[2-Amino-1,3-Thiazolyl]-Thiophene-2-Carboxamidine Is Described. Further Optimization Of This Series By Substitution Of The Terminal Amine Yielded Urokinase Inhibitors With Excellent Activities. (C) 2001 Elsevier Science Ltd. All Rights Reserved.
    DOI:10.1016/s0960-894X(01)00102-0

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    专利信息


    专利号:US-4656291-A
    优先权日:1985-03-15
    标 题 :Process for producing amidine sulfonic acids
    发明人：MARYANOFF CYNTHIA A; PLAMPIN JAMES N; STANZIONE ROBIN C
    权利人:MCNEILAB INC
    摘要:An efficient synthesis of quanidines, e.g. of the formula (III), by oxidizing a thiourea, e.g. of the following formula (II): with H2O2 and a molybdenum catalyst to yield an aminoiminomethane sulfonic acid which can then be reacted with an amine followed by optional transamination steps.

    专利号:US-4781866-A
    优先权日:1985-03-15
    标题 :Process for producing amidine sulfonic acid intermediates for guanidines
    发明人：MARYANOFF CYNTHIA A; PLAMPIN JAMES N; STANZIONE ROBIN C
    权利人:MCNEILAB INC
    摘要:An efficient synthesis of quanidines, e.g. of the formula (III), by oxidizing a thiourea, e.g. of the following formula (II): with H2O2 and a molybdenum catalyst to yield an aminoiminomethane sulfonic acid which can then be reacted with an amine followed by optional transamination steps.

    专利号:US-4851094-A
    优先权日:1985-03-15
    标 题:Process for producing amidine sulfonic acid intermediates for guanidines
    发明人：MARYANOFF CYNTHIA A; PLAMPIN JAMES N; STANZIONE ROBIN C
    权利人:MCNEILAB INC
    摘要:An efficient synthesis of quanidines, e.g. of the formula (III), by oxidizing a thiourea, e.g. of the following formula (II): (III) (II) with H2O2 and a molybdenum catalyst to yield an aminoiminomethane sulfonic acid which can then be reacted with an amine followed by optional transamination steps.

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    合成参考文献


    摘要:Kleemann, A.; Engel, J.; Kutscher, B.; Reichert, D., Pharmaceutical Substances[Online], Thieme: Stuttgart, (2003).
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