CAS: 62218-08-0; 5-((2R,3R)-6-Hydroxy-2-(4-Hydroxyphenyl)-4-((E)-4-Hydroxystyryl)-2,3-Dihydrobenzofuran-3-yl)Benzene-1,3-Diol
该化合物是复杂的有机化合物,具有多酚结构的特点.这种化合物具有多种氢氧化合物组的特点,有助于其潜在的抗氧化特性.一种苯丙胺混合物的存在表明,它可能表现出生物活动,可能影响各种生物化学途径.由(2R,3R)配置所标明的立体化学学表明,具体的空间安排可能会影响其与生物目标的相互作用.此外,该化合物的结构包括多个芳香环,可能增强有机溶剂的稳定性和溶解性.这些特性使得它对于诸如药化学和药理学等领域具有兴趣,可以用于治疗用途.
- 英文名称5-((2R,3R)-6-Hydroxy-2-(4-Hydroxyphenyl)-4-((E)-4-Hydroxystyryl)-2,3-Dihydrobenzofuran-3-yl)Benzene-1,3-Diol
- 中文名称epsilon-白藜芦醇脱氢二聚体
- IUPAC名称5-((2R,3R)-6-hydroxy-2-(4-hydroxyphenyl)-4-((E)-4-hydroxystyryl)-2,3-dihydrobenzofuran-3-yl)benzene-1,3-diol
- 其它别名1,3-Benzenediol, 5-(2,3-Dihydro-6-Hydroxy-2-(4-Hydroxyphenyl)-4-(2-(4-Hydroxyphenyl)Ethenyl)-3-Benzofuranyl)-, (2R-(2.Alpha.,3.Beta.,4(E)))-; 5-(2,3-Dihydro-6-Hydroxy-2(4-Hydroxyphenyl)4-(2-(4-Hydroxyphenyl)Ethenyl)-3-Benzofuranyl)-1,3-Ben
- CAS编号62218-08-0
- MFCD编号:MFCD12964987
- EINECS号:805-135-6
- FDA UNII编号:0K8Z2K6Y7O
- 分子式:C28H22O6分子量:454.48
- 产品CID: 1604256
- 产品分类天然产物 → 酚类
物理性质
- 熔点approximate 157°C (分解)
- 沸点147 - 149 °C
- 闪点374 °C
- 密度3>1.45g/ cm3
- PSA:110.38
- LogP:3.802 (est)
- 蒸汽压6.04E-20 mmHg at 25 °C
- 溶解性Soluble In Methanol;
- 外观形态类白色至灰色粉末
- 储存条件储存在 -20°C
- 产品应用该化合物是从维他命维他林提取的活性抗氧化活性强和有效抑制各种细胞色素P450(CYP)酶(包括CY P2B6 (KI = 3 ΜM),CYP1A2(KI= 5 微M), CYP3A4(KI 为 10 微米),CYP4A(IC50 =15 微MM),SYP2E1 (IC50= 25 微MIM)和CYPC2A6 (KI 等于 60 微姆).
MSDS等安全信息
上下游产品
(E)-5-[2-4-(hydroxyphenyl)ethenyl]-1,3-benzenediol 1-(β-D-glucopyranosyloxy)-5-{(2R,3R)-6-(β-glucopyranosyloxy)-2-(4-hydroxyphenyl)-4-[(E)-4-hydroxystyryl]-2,3-dihydrobenzofuran-3-yl}benzene-3-ol (E)-5-((+/-)-6-hydroxy-2-(4-hydroxyphenyl)-4-(4-hydroxystyryl)-2,3-dihydrobenzofuran-3-yl)benzene-1,3-diolcis ε-viniferine viniferifuran (-)-ε-Viniferin pentamethyl ether 4-hydroxy-benzaldehyde合成工艺路线路线简述
📜1-(β-D-Glucopyranosyloxy)-5-{(2R,3R)-6-(β-Glucopyranosyloxy)-2-(4-Hydroxyphenyl)-4-[(E)-4-Hydroxystyryl]-2,3-Dihydrobenzofuran-3-Yl}Benzene-3-Ol置于水,β-Glucosidase体系中,化学反应 24.0H,以0.3 Mg的收率获得产物epsilon-白藜芦醇脱氢二聚体
参考文献:梵蒂冈白藜芦醇的白藜芦醇低聚物
标题:梵蒂冈白藜芦醇的白藜芦醇低聚物
摘要:五个新的茋类,Vatalbinosides A-E(1-5),以及13种公知的化合物(6-18)从茎中分离青梅albiramis.研究了这些新化合物对白细胞介素1β诱导的人皮肤成纤维细胞基质金属蛋白酶-1(mmp-1)产生的影响.三种白藜芦醇四聚体(-)-胡豆酚(6),梵蒂冈c(13)和十八醇c(14)被确定为mmp-1产生的强抑制剂.
DOI:10.1021/np1002675
海关参考信息
- 2901210000-乙烯
2902500000-苯乙烯
2902600000-乙苯
2906210000-苄醇 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-2014243404-A1
优先权日:2010-09-14
标题 :Unique halogen-induced cyclizations, reagents therefor, and compounds produced thereby
发明人：SNYDER SCOTT ALAN; TREITLER DANIEL S; BRUCKS ALEXANDRIA P; GOLLNER ANDREAS; CHIRIAC MARIA I; WRIGHT NATHAN E; PFLUEGER JASON J; BREAZZANO STEVEN P
权利人:SNYDER SCOTT ALAN; TREITLER DANIEL S; BRUCKS ALEXANDRIA P; GOLLNER ANDREAS; CHIRIAC MARIA I; WRIGHT NATHAN E; PFLUEGER JASON J; BREAZZANO STEVEN P; UNIV COLUMBIA
摘要:This disclosure is related to halonium compounds useful for cyclization of polyenes, alkenoic acids, and alkenyl alkyl ethers, and halogenation of aromatic compounds. The synthesis of such halonium compounds, compounds made using such halonium compounds, and synthesis of natural compounds, including decalins, using the halonium compounds is also disclosed. A representative halonium compound of the disclosure is:
专利号:FR-2937546-A1
优先权日:2008-10-28
标题 :COSMETIC AND PHARMACEUTICAL TREATMENT METHOD FOR REDUCING BOTH ENDOGENOUS SYNTHESIS OF SIRTUINE AND REDUCING MUSCULAR CONTRACTIONS AND COMPOSITIONS FOR ITS IMPLEMENTATION
专利号:FR-2937545-A1
优先权日:2008-10-28
标 题 :COSMETIC AND PHARMACEUTICAL TREATMENT METHOD FOR REDUCING BOTH ENDOGENOUS SYNTHESIS OF SIRTUINE AND REDUCING MUSCULAR CONTRACTIONS AND COMPOSITIONS FOR ITS IMPLEMENTATION
专利号:CN-108289809-B
优先权日:2015-06-05
标题:Methods of stimulating hyaluronic acid synthesis
专利号:CN-115612114-A
优先权日:2021-07-14
标 题:Method and application of copolymer film and its enzymatic self-assembly synthesis
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1. Vitrac, X., Bornet, A., Vanderlinde, R., et al. Determination of stilbenes (δ-viniferin, trans-astringin, trans-piceid, cis- and trans-resveratrol, ε-viniferin) in Brazilian wines. J. Agric. Food Chem. 53(14), 5664-5669 (2005). 2. Vion, E., Page, G., Bourdeaud, E., et al. Trans ε-viniferin is an amyloid-β disaggregating and anti-inflammatory drug in a mouse primary cellular model of Alzheimer’s disease. Mol. Cell Neurosci. 88, 1-6 (2018). 3. Fu, J., Jin, J., Cichewicz, R.H., et al. trans-(−)-ε-Viniferin increases mitochondrial sirtuin 3 (SIRT3), activates AMP-activated protein kinase (AMPK), and protects cells in models of Huntington Disease. J. Biol. Chem. 287(29), 24460-24472 (2012). 4. Yu, B., Jiang, Y., Zhang, B., et al. Resveratrol dimer trans-ε-viniferin prevents rotaviral diarrhea in mice by inhibition of the intestinal calcium-activated chloride channel. Pharmacol. Res. 129, 453-461 (2018). 5. Ohara, K., Kusano, K., Kitao, S., et al. ε-Viniferin, a resveratrol dimer, prevents diet-induced obesity in mice. Biochem. Bioph. Res. Commun. 468(4), 877-882 (2015). Product Citations Ohara, K., Kusano, K., Kitao, S., et al. ε-Viniferin, a resveratrol dimer, prevents diet-induced obesity in mice. Biochem. Bioph. Res. Commun. 468(4), 877-882 (2015).合成参考文献
参考文献:10.1021/jf201181n
摘要:Santamaria AR, Mulinacci N, Valletta A, Innocenti M, Pasqua G. Effects of elicitors on the production of resveratrol and viniferins in cell cultures of Vitis vinifera L. cv Italia. J Agric Food Chem. 2011 Sep 14;59(17):9094–101. doi: 10.1021/jf201181n.
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