CAS: 579-38-4; 2,2-Dichloro-N-(4-Hydroxyphenyl)-N-Methylacetamide

上下游产品

methanol diloxanide furoateα,α-Dichlor-N-methyl-p-(4-methylsulfonyl-benzoyloxy)-acetanilid α,α-Dichlor-N-methyl-p-(4-methylsulfonyl-benzyloxy)-acetanilid 2,2-Dichloro-N-methyl-N-[4-(1-methyl-5-nitro-1H-imidazol-2-yloxy)-phenyl]-acetamide

📜甲醇,糠酸二氯尼特置于phosphate Buffer体系中,用 乙腈 作为反应溶剂,化学反应生成 糠酸(呋喃甲酸),2-糠酸甲酯,二氯尼特
参考文献:Stability Studies On Diloxanide Furoate: Effect Of Ph,Temperature,Gastric And Intestinal Fluids
标题:Stability Studies On Diloxanide Furoate: Effect Of Ph,Temperature,Gastric And Intestinal Fluids
摘要:The Degradation Of The Amoebicide Diloxanide Furoate In Alkaline Medium At Different Temperatures Was Investigated Using Both A Spectrophotometric And A Developed HPLC Method. In Solutions,The Drug Was Found To Undergo Decomposition,I.E.,Temperature And Ph Dependent. The Ph-Rate Profile At Ph Between 7.6 And 9.6 Indicated A First-Order Dependence Of Kobs On [-Oh]. Arrhenius Plot Obtained At Ph 8 Was Linear Between 40 And 63 Degrees C. The Estimated Activation Energy Of Hydrolysis Was Found To Be 18.25 Kcal Degree.Mol(-1). The Effect Of Simulated Gastric And Intestinal Fluids On The Drug Was Also Investigated. A New Thin-Layer Chromatographic (Tlc) Procedure For The Fractionation Of The Drug And Its Alkaline Hydrolysis Products Has Been Developed And Was Found To Compare Favorably With That Of The British Pharmacopoeia. Three Hydrolysis Products Of A Basic Methanolic Solution Of The Drug,Namely Furoic Acid,Diloxanide And Methylfuroate Could Be Identified By The Use Of Tlc,HPLC,Infrared And Mass Spectrometry.
DOI:10.1016/j.Farmac.2003.11.015

专利信息

专利号:US-9382288-B2
优先权日:2010-10-06
标题 :Derivatives of steroid benzylamines, having an antiparasitic antibacterial, antimycotic and/or antiviral action
发明人：BECKER KATJA; KRIEG REIMAR; SCHÖNECKER BRUNO
权利人:BECKER KATJA; KRIEG REIMAR; SCHÖNECKER BRUNO; UNIV GIESSEN JUSTUS LIEBIG
摘要:The present invention relates to compounds derived from steroids of the general formula (I) n nwherein L represents a linker and R # represents a steroid residue, the use of compounds of the general formula (I) in medicine and for the prophylaxis and/or the treatment of infectious diseases. Furthermore described are pharmaceutical compositions containing at least one compound of the general formula (I). A further aspect of the invention relates to the synthesis of said compounds of the general formula (I).

专利号:US-9907753-B2
优先权日:2010-03-19
标 题 :Lipid vesicle compositions and methods of use
发明人：IRVINE DARRELL J; MOON JAEHYUN
权利人:MASSACHUSETTS INST TECHNOLOGY
摘要:The invention provides delivery systems comprised of stabilized multilamellar vesicles, as well as compositions, methods of synthesis, and methods of use thereof. The stabilized multilamellar vesicles may comprise prophylactic, therapeutic and/or diagnostic agents.