CAS: 56522-24-8; [tert-Butyl(Dimethyl)Silyl]Formonitrile

📜叔丁基二甲基氯硅烷置于amberlite Xad-4,氰化钠体系中,用 乙腈 作为反应溶剂,化学反应 4.0H,以85%的收率获得产物叔丁基氰基二甲基硅烷
参考文献:使用浸渍在 Amberlite Xad 树脂上的氰化钾或氰化钠合成烷基甲硅烷基氰化物的简便方法
标题:使用浸渍在 Amberlite Xad 树脂上的氰化钾或氰化钠合成烷基甲硅烷基氰化物的简便方法
摘要:发现浸渍在 Amberlite Xad 树脂上的氰化钾和氰化钠可在温和条件下有效地将烷基氯硅烷转化为相应的烷基氰化硅烷.
DOI:10.1246/bcsj.60.2257

专利信息

专利号:US-5157143-A
优先权日:1988-05-11
标题 :Diastereoselective process for the preparation of intermediates useful for the synthesis of peptide derivatives
发明人：PELLACINI FRANCO; CHIARINO DARIO; CARENZI ANGELO
权利人:ZAMBON SPA
摘要:A diastereoselective process for the preparation of compounds of formula ##STR1## (wherein R and R 1 have the meanings reported in the specification and the asterisks show the asymmetric carbon atoms) starting from the corresponding N-protected 2-amino-3-aryl-propan-1-ol is described. n The compounds of formula I are intermediates useful for the synthesis of pharmacologically active peptides.

专利号:US-2016073631-A1
优先权日:2013-03-04
标 题 :Process for the preparation of dihydropyrrole derivatives
发明人：EL QACEMI MYRIEM; SMITS HELMARS; CASSAYRE JEROME YVES; MULHOLLAND NICHOLAS PHILLIP; RENOLD PETER; GODINEAU EDOUARD; PITTERNA THOMAS
权利人:SYNGENTA PARTICIPATIONS AG; SYNGENTA LTD
摘要:The present invention provides stereoselective processes for the preparation of compounds of formula (I) n n n n n n n n n n n n wherein n P is phenyl, naphthyl, a 6-membered heteroaryl group containing one or two nitrogen atoms as ring members, or a 10-membered bicyclic heteroaryl group containing one or two nitrogen atoms as ring members, and wherein the phenyl, naphthyl and heteroaryl groups are optionally substituted; n R 1 is chlorodifluoromethyl or trifluoromethyl; n R 2 is optionally substituted aryl or optionally substituted heteroaryl; n n is 0 or 1; n including the process comprising n (a-i) reacting a compound of formula II n n n n n n n n n n n n n n n n wherein P, R 1 and R 2 are as defined for the compound of formula I; n with nitromethane in the presence a chiral catalyst to give a compound of formula III n n n n n n n n n n n n n n n n wherein P, R 1 and R 2 are as defined for the compound of formula I; and n (a-ii) reductively cyclising the compound of formula III to give the compound of formula I. n n n n n The invention also provides intermediates useful for processes for the synthesis of compounds of formula (I).

专利号:US-8030496-B2
优先权日:2005-02-17
标 题:Intermediate compound for synthesis of viridiofungin a derivative
发明人：KATO TATSUYA; KIMURA NOBUAKI; MIZUTANI AKEMI; MAKINO TOSHIHIKO; KAWASAKI KENICHI; FUKUDA HIROSHI; KOMIYAMA SUSUMU; TSUKUDA TAKUO
权利人:CHUGAI PHARMACEUTICAL CO LTD
摘要:A method whereby a compound having HCV replication inhibitory activity and desired optical activity can be synthesized selectively and at high yield in a small number of steps by using a compound having a specific chiral auxiliary as a starting compound is provided. n A compound represented by the formula (1-8): n n n n n n n n n n n n wherein Y represents a group represented by the following formula: n n n n n n n n n n n n n n n n Q represents a protected carbonyl group; D represents —(CH 2 ) m —R′, etc.; and n represents an integer of 0 to 10.

专利号:EP-0341462-A1
优先权日:1988-05-11
标题 :Diastereoselective process for the preparation of intermediates useful for the synthesis of peptide derivatives

专利号:EP-0341462-B1
优先权日:1988-05-11
标题 :Diastereoselective process for the preparation of intermediates useful for the synthesis of peptide derivatives

专利号:US-2010152456-A1
优先权日:2005-02-17
标题 :Intermediate compound for synthesis of viridiofungin a derivative