专利号:US-6171614-B1 优先权日:1996-10-15 标 题 :Synthesis of glycophospholipid and peptide-phospholipid conjugates and uses thereof 发明人:CHAIKOF ELLIOT L; SUN LIJUN 权利人:UNIV EMORY 摘要:The present invention provides glycophospholipid and peptide-phospholipid conjugates comprising a phospholipid moiety and a saccharide or peptide moiety joined by an ether linkage comprising a secondary or tertiary amine. The conjugate structure of the invention comprises a flexible spacer arm between the phospholipid and saccharide or peptide moieties which, being variable in length, serves to optimize saccharide or peptide bioactivity. This invention further provides a method for the synthesis of such conjugates comprising the step of reductive amination. The method is efficient, economical and provides a high yield of product. Glycophospholipid and peptide-phospholipid conjugates of the invention can be incorporated and, optionally, chemically polymerized in self-assembling systems such as membranes, bilayers, films, liposomes and the like, and find utility diagnostically and therapeutically in medical and immuno-biological applications.
专利号:US-7482059-B2 优先权日:2004-05-10 标 题:Semiconductor nanocrystal complexes comprising a metal coating and methods of making same 发明人:PENG ADAM; LIU WEI 权利人:EVIDENT TECHNOLOGIES 摘要:A semiconductor nanocrystal complex including a metal layer formed on the outer surface of a semiconductor nanocrystal core after synthesis of the semiconductor nanocrystal core and a method for preparing a nanocrystal complex comprising forming a metal layer on a semiconductor nanocrystal core after synthesis of the semiconductor nanocrystal core. The metal layer may passivate the surface of the semiconductor nanocrystal core and protect the semiconductor nanocrystal core from the effects of oxidation. Also provided is a semiconductor nanocrystal complex with a shell grown onto the metal layer formed on the semiconductor nanocrystal core. In this embodiment, the metal layer may prevent lattice mismatch between the semiconductor shell and the semiconductor nanocrystal core.
专利号:US-7160489-B2 优先权日:2003-10-10 标 题:Controlled chemical aerosol flow synthesis of nanometer-sized particles and other nanometer-sized products 发明人:DIDENKO YURI T; SUSLICK KENNETH S 权利人:UNIV ILLINOIS 摘要:A method and apparatus for producing nanometer-sized particles, the method including the steps of forming of mixture by mixing a first precursor reactant, a second precursor reactant, a surface-stabilizing surfactant, and a high boiling point liquid to form a mixture, forming a mist of droplets of the mixture, heating the droplets to cause a reaction between species of the first and second precursor reactants within the heated droplets, and collecting the nanometer-sized products.
专利号:US-2009220792-A1 优先权日:2006-01-20 标题 :Synthesis of Alloyed Nanocrystals in Aqueous or Water-Soluble Solvents 发明人:YING JACKIE Y; ZHENG YUANGANG 权利人:SINGAPORE AGENCY FOR SCIENCE T 摘要:The present invention relates to nanocrystals and methods for making the same; in particular, the invention relates to ternary or higher alloyed nanocrystals and methods for making such structures in aqueous or water-soluble solvents. In certain embodiments of the invention, methods of preparing ternary or higher alloyed nanocrystals involve providing at least first, second, and third nanocrystal precursors (e.g., NaHSe, ZnCl 2 , and CdCl 2 ) and forming nanocrystal structures in an aqueous or water-soluble solvent. In some cases, nanocrystal precursor solutions may also include a water-soluble ligand (e.g., glutathione, GSH). As such, ternary or higher alloyed nanocrystals (e.g., Zn x Cd)— x Se) comprising the at least first, second, and third nanocrystal precursors may be formed, and the water-soluble ligand may coat at least a portion of the surface of the ternary or higher alloyed nanocrystal. Advantageously, methods for forming nanocrystals described herein can be performed at low temperatures (e.g., less than 100 degrees Celsius), and, in some embodiments, do not require the use of organic solvents. The present inventors have applied these methods to prepare blue-emitting nanocrystals with emissions that are tunable between 400-500 nm, and with quantum yields of greater than 25% in aqueous solution. These nanocrystals may be highly water soluble and can be used in a variety of applications, including those involving cell culture, sensing applications, fluorescence resonance energy transfer, and in light-emitting devices.
专利号:US-6229055-B1 优先权日:1996-04-12 标题 :Synthesis of fluorinated xanthene derivatives 发明人:KLAUBERT DIETER H; GEE KYLE R 权利人:MOLECULAR PROBES INC 摘要:Facile syntheses for fluorinated resorcinol and aminophenol derivatives are provided that yield isomer-free products in good yield. These novel methods use generally available precursors and standard laboratory reagents and equipment to reproducibly produce these synthetically useful reagents in relatively large quantities. The resulting fluorinated resorcinols and aniinophenols possess utility in the preparation of fluorinated fluorescein and rhodol dyes.
专利号:US-2011229397-A1 优先权日:2008-10-03 标 题:Process and apparatus for continuous flow synthesis of nanocrystals 发明人:BARTEL JOSEPH; MCKENZIE LALLIE 权利人:LIFE TECHNOLOGIES CORP 摘要:Novel reactor, systems and methods of preparing nanocrystals in a continuous flow-through process are provided. The novel reactor is highly configurable and can be modified to achieve desired reaction times of a flow through mixture. The reactor is designed to provide uniform, efficient heating of the reaction mixture.
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合成参考文献
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