专利号:US-2004110228-A1 优先权日:2002-04-01 标 题:Combinatorial organic synthesis of unique biologically active compounds 发明人:MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M 摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.
专利号:WO-2004111011-A2 优先权日:2003-05-30 标 题:Synthesis of 2-aryl pyrimidine 4-carboxylic acid amides
专利号:US-2025026766-A1 优先权日:2022-01-12 标题 :Thiazolopyridyl Amide Derivatives as DNA Polymerase Theta Inhibitors 发明人:LI JING; XU WENQING; WANG ZHIWEI 权利人:BEIGENE LTD 摘要:The present invention relates to compounds containing thiazolopyridyl amide structure, the process for their synthesis, as well as the use of such compounds for inhibiting DNA Polymerase Theta (Pol Theta), and in the treatment of various diseases including cancers.
专利号:RU-2194701-C2 优先权日:1995-12-18 标 题 :Derivatives of quinazoline, methods of their synthesis, pharmaceutical composition comprising thereof and method of achievement of anti-angiogenic effect and/or effect of decrease of vascular penetration with their using
专利号:US-4198527-A 优先权日:1978-09-15 标题 :Ether substituted cyclopropanecarboxylic acids and esters 发明人:HENRICK CLIVE A 权利人:ZOECON CORP 摘要:Novel esters of ether and thioether substituted cyclopropanecarboxylic acids, synthesis thereof, and intermediates therefor, such esters being useful as pesticides.
专利号:US-2010280024-A1 优先权日:2007-10-15 标 题:Renin inhibitors 发明人:DESAI JIGAR; THOMBARE PRAVIN S; JAIN MUKUL R; PATEL PANKAJ RAMANBHAI 权利人:DESAI JIGAR; THOMBARE PRAVIN S; JAIN MUKUL R; PATEL PANKAJ RAMANBHAI 摘要:The present invention relates to renin inhibitors of formula (I), their pharmaceutically acceptable salts and pharmaceutical compositions containing them. The present invention also relates to a process of preparing compounds of general formula (I), their tautomeric forms, their pharmaceutically acceptable salts, pharmaceutical compositions containing them, and novel intermediates involved in their synthesis.
[参考文献]: Inna P Solyanikova, Et Al. Conversion Of 2-Fluoromuconate To Cis-Dienelactone By Purified Enzymes Of Rhodococcus Opacus 1Cp. Appl Environ Microbiol. 2003 Sep;69(9):5636-42.
合成参考文献
摘要:Sandford, G., Science of Synthesis, (2007) 31, 24. 摘要:Sandford, G., Science of Synthesis, (2007) 31, 31.