CAS: 2566-23-6; N-Benzoyl-L-Tyrosine

相似化合物

3483-82-7 2566-22-5 2901-76-0

上下游产品

(rac)-N-Benzoyltyrosin-ethylester L-tyrosine benzoyl chloride BzTyr-p-nitroanilideN-(N-benzoyl-L-tyrosyl)-glycine anilideN-(N-benzoyl-L-tyrosyl)-glycine anilide N-benzoyl-L-tyrosine ethyl ester benzoyl L-aspartic acid N-benzoyl-L-tyrosine anilideN-benzoyl-L-tyrosine anilide

📜N-苯甲酰-L-酪氨酸乙酯置于bovine Tlck-Treated Chymotrypsin体系中,用 二甲基亚砜 用作溶剂,化学反应 0.08H,反应生成N-苯甲酰-L-酪氨酸
参考文献:Site-Selective Chemical Modification Of Chymotrypsin Using A Peptidyl Diphenyl 1-Amino-2-Phenylethylphosphonate Derivative
标题:Site-Selective Chemical Modification Of Chymotrypsin Using A Peptidyl Diphenyl 1-Amino-2-Phenylethylphosphonate Derivative
摘要:为了在胰凝乳蛋白酶(csin)活性位点附近进行位点选择性化学修饰,肽衍生物 1 带有用于靶向活性位点的二苯基 1-氨基-2-苯乙基膦酸酯部分和用于锚定赖氨酸残基的活性酯部分设计并合成.大部分 Csin 被 1 灭活 10 分钟,然后通过与 2-吡啶醛肟甲碘化物一起孵育重新激活,得到修饰的 Csin.修饰的 Csin 的质谱分析表明 1 选择性锚定在 Lys175 处.
Doi:10.1246/cl.130244

专利信息

专利号:US-9783800-B2
优先权日:2014-02-03
标 题:Method for producing peptides having azole-derived skeleton
发明人：SUGA HIROAKI; GOTO YUKI; KATO YASUHARU
权利人:UNIV TOKYO
摘要:Object of the present invention is to develop an artificial synthesis system of various peptides having an azole derivative structure and develop a library of such peptides. The present invention provides a method of producing a peptide having, in the backbone thereof, an azole derivative structure comprising the step of: synthesizing a substrate peptide of an azoline structure introducing enzyme having, in the modified region thereof, at least any one of the following amino acids, n n[in any of the compounds,n X 1 represents a group selected from the group consisting of SH, OH, NH 2 , SR 1 , OR 1 , NHR 1 , and N 3 (R 1 represents a protecting group), X 2 represents an easily eliminable group; and X 3 represents hydrogen or a substituted or unsubstituted alkyl or aryl group having from 1 to 10 carbon atoms]; reacting the substrate peptide with an azoline structure introducing enzyme to obtain a peptide having an azoline derivative structure; and converting the azoline derivative structure of the resulting peptide into an azole derivative structure by inducing an HX 2 elimination reaction of X 2 group.

专利号:CN-120309503-A
优先权日:2025-04-26
标题 :Synthesis method of intermediate for preparing hydrochloric acid Luo Xianan

专利号:CN-115850107-A
优先权日:2022-11-30
标题 :A kind of method of industrialized synthesis tiromide hydrochloride

专利号:CN-115850107-B
优先权日:2022-11-30
标 题:Industrial synthesis method of hydrochloric acid Luo Xianan