CAS: 24305-27-9; L-Pyroglutamyl-L-Histidyl-L-Prolinamide

该化合物是三相激素,由三种氨基酸组成:青甘菊酸,丁丁和proline,通过刺激从腹部垂垂垂地释放甲状腺刺激性激素(TSH),在调节甲状体功能方面发挥着至关重要的作用.TRH在低脑脑膜下合成,并参与低脑-腹部-胸腔轴,影响代谢过程和能量软化.CAS编号24305-27-9专门识别了这种peptide,通常以固态或液化的形式出现,用于研究和治疗用途.THRH是水溶质的,可通过不同途径,包括静脉注射或亚肾注射进行,其生物活动通过在垂体腹地的特定感应器进行介介介,从而对甲状物激素生产产生下游影响.此外,还研究过TRRH,因为它在各种生理和病理条件下的潜在作用,包括对情绪和压力反应的影响.

结构式图片

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ECHA物质C&L通报REACH预注册

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CAS号28613-24-3 (2S)-2-amino-N-... | CAS号83468-78-4 L-pyroglutamyl-... | CAS号1162640-73-4 Pyroglutamylhis... | CAS号7531-52-4 L-脯氨酰胺 | CAS号83468-77-3 N(α)-t-butoxyca... | CAS号83468-76-2 (S)-methyl 2-(t... | CAS号83480-22-2 N(α)-t-butoxyca... | CAS号2488-14-4 N-B°C-L-组氨酸 甲酯 | CAS号53100-44-0 N-叔丁氧羰基-L-焦谷氨酸

合成工艺路线路线简述

    在 Palladium On Activated Charcoal,Rh On Carbon Amberlite Ir 45 (Acetate Form),氢气,三乙胺体系中,用 溶剂黄146,N,N-二甲基甲酰胺 用作溶剂,化学反应 22.0H,反应生成大鼠转铁蛋白
    参考文献:Brown,Tom; Jones,John H.; Richards,John D.,Journal Of The Chemical Society. Perkin Transactions I,1982,# 7,P. 1553-1562
    标题:Brown,Tom; Jones,John H.; Richards,John D.,Journal Of The Chemical Society. Perkin Transactions I,1982,# 7,P. 1553-1562

    海关参考信息

    专利信息


    专利号:US-8314209-B2
    优先权日:2007-12-12
    标 题 :Lipid-assisted synthesis of polymer compounds and methods for their use
    发明人:RAJAMANI SUDHA; OLASAGASTI FELIX; DEAMER DAVID W; BENNER SEICO
    权利人:RAJAMANI SUDHA; OLASAGASTI FELIX; DEAMER DAVID W; BENNER SEICO; UNIV CALIFORNIA
    摘要:The invention herein disclosed provides for methods for the synthesis of polymers from monomers. In particular the method provides for the synthesis of polynucleotides from mononucleotides in the absence of catalytic enzymes. The method comprises providing an aqueous solution having a plurality of phospholipid molecules and monomer molecules; subjecting the aqueous solution to fluctuating temperature conditions; subjecting the aqueous solution to fluctuating cycles of drying and hydrating conditions; subjecting the aqueous solution to fluctuating [H + ] conditions; the fluctuating conditions thereby allowing formation of a chemical bond between at least two monomers to create a polymer. The invention is of particular use in the fields of molecular biology, structural biology, cell biology, molecular switches, molecular circuits, and molecular computational devices, and the manufacture thereof.

    专利号:EP-0097994-B1
    优先权日:1982-06-24
    标 题:Method for the solid-phase synthesis of retro-inverso polypeptides
    摘要:This invention relates to a method for the solid-phase synthesis of polypeptides containing retro-inverted peptide bonds, using polydimethylacrylamide-co-acryloylsarcosimethylester resin cross-linked with N, N min -ethylene-bis-acrylamide as the insoluble support for lengthening the polypeptide chain in stages by the addition of suitable amino acid derivatives and/or peptides in succession. In particular, the method described in the present invention allows the easy preparation, on the polymer matrix, of monoacylated gem-diamino residues using the reagent I, I-bis (trifluoroacetoxy) iodobenzene in mixed aqueous-organic solvents.

    专利号:US-2005164912-A1
    优先权日:2003-12-31
    标 题:Methods for recovering cleaved peptide from a support after solid phase synthesis
    发明人:BIGELOW ROGER D; CAIN ROBERT O
    摘要:Methods for the solid phase synthesis of peptides and peptide intermediates, in particular methods involving recovering peptides from resin supports at excellent yield. In this invention, an alternating at least partially repeating cycle of shrinking and swelling treatments are used. Each shrinking or swelling part of a cycle may involve one or more washes. The process provides excellent recovery of peptide in a very efficient manner in terms of the number of individual washes and the total volume of wash reagents used.

    专利号:WO-9108220-A1
    优先权日:1989-12-01
    标 题:A method for the stepwise, controlled synthesis of chemical species, particularly peptides, coupled products obtained by the method and the use of these coupled products, e.g. as vaccines
    发明人:HOUEN GUNNAR; HOLM ARNE
    权利人:HOUEN GUNNAR; HOLM ARNE
    摘要:Chemical species, particularly peptides, are synthesized by a stepwise, controlled process, in which a proteinaceous substance such as a protein is used as the synthesis substrate. The products obtained by the process can be used e.g. as vaccines against various diseases and as matrix materials or carrier molecules.

    专利号:US-4873342-A
    优先权日:1985-04-16
    标题:Dipeptide derivative and synthesis and use thereof
    发明人:TANAKA TAKAHARU; SAITOH MASAYUKI; HIGUCHI NAOKI; HASHIMOTO MASAKI
    权利人:SUNTORY LTD
    摘要:A novel depeptide derivative which exhibits inhibitory activity against prolyl endopeptidase and is effective for preventing and curing amnesia is disclosed. A process for chemical synthesis of such a derivative, as well as its use, is also disclosed.

    专利号:US-9574189-B2
    优先权日:2005-12-01
    标题:Enzymatic encoding methods for efficient synthesis of large libraries
    发明人:FRANCH THOMAS; LUNDORF MIKKEL DYBRO; JACOBSEN SØREN NYBOE; OLSEN EVA KAMPMANN; ANDERSEN ANNE LEE; HOLTMANN ANETTE; HANSEN ANDERS HOLM; SØRENSEN ANDERS MALLING; GOLDBECH ANNE; DE LEON DAEN; KALDOR DITTE KIEVSMOSE; SLØK FRANK ABILDGAARD; HUSEMOEN GITTE NYSTRUP; DOLBERG JOHANNES; Jensen Kim Birkebæ; PEDERSEN LENE; NØRREGAARD-MADSEN MADS; GODSKESEN MICHAEL ANDERS; GLAD SANNE SCHRØDER; NEVE SØREN; THISTED THOMAS; KRONBORG TINE TITILOLA AKINLEMINU; SAMS CHRISTIAN KLARNER; FELDING JAKOB; FRESKGÃ…RD PER-OLA; GOULIAEV ALEX HAAHR; PEDERSEN HENRIK
    权利人:FRANCH THOMAS; LUNDORF MIKKEL DYBRO; JACOBSEN SØREN NYBOE; OLSEN EVA KAMPMANN; ANDERSEN ANNE LEE; HOLTMANN ANETTE; HANSEN ANDERS HOLM; SØRENSEN ANDERS MALLING; GOLDBECH ANNE; DE LEON DAEN; KALDOR DITTE KIEVSMOSE; SLØK FRANK ABILDGAARD; HUSEMOEN GITTE NYSTRUP; DOLBERG JOHANNES; Jensen Kim Birkebæ; PEDERSEN LENE; NØRREGAARD-MADSEN MADS; GODSKESEN MICHAEL ANDERS; GLAD SANNE SCHRØDER; NEVE SØREN; THISTED THOMAS; KRONBORG TINE TITILOLA AKINLEMINU; SAMS CHRISTIAN KLARNER; FELDING JAKOB; FRESKGÃ…RD PER-OLA; GOULIAEV ALEX HAAHR; PEDERSEN HENRIK; NUEVOLUTION AS
    摘要:Disclosed is a method for obtaining a bifunctional complex comprising a molecule linked to a single stranded identifier oligonucleotide, wherein a nascent bifunctional complex comprising a chemical reaction site and a priming site for enzymatic addition of a tag is a) reacted at the chemical reaction site with one or more reactants, and b) reacted enzymatically at the priming site with one or more tag(s) identifying the reactant(s).
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    主要参考文献


    1: Ohuchi K, Funato M, Kato Z, Seki J, Kawase C, Tamai Y, Ono Y, Nagahara Y, Noda Y, Kameyama T, Ando S, Tsuruma K, Shimazawa M, Hara H, Kaneko H. Established Stem Cell Model of Spinal Muscular Atrophy Is Applicable in the Evaluation of the Efficacy of Thyrotropin-Releasing Hormone Analog. Stem Cells Transl Med. 2016 Feb;5(2):152-63. doi: 10.5966/sctm.2015-0059. Epub 2015 Dec 18.
    2: Kaur S, Bhararia A, Sharma K, Mittal S, Jain R, Wangoo N, Sharma RK. Thyrotropin-Releasing Hormone Loaded and Chitosan Engineered Polymeric Nanoparticles: Towards Effective Delivery of Neuropeptides. J Nanosci Nanotechnol. 2016 May;16(5):5324-32. doi: 10.1016/j.ejphar.2015.05.047. Epub 2015 Jul 2. doi: 10.1016/j.npep.2015.08.001. Epub 2015 Aug 5. Review. doi: 10.1038/jp.2015.67. Epub 2015 Jun 25. doi: 10.1016/j.neuroscience.2015.10.015. Epub 2015 Oct 22. doi: 10.1016/j.bmc.2015.07.022. Epub 2015 Jul 17. doi: 10.1016/j.neuropharm.2014.09.024. Epub 2014 Sep 30. doi: 10.2460/ajvr.76.5.437. doi: 10.1016/j.bbadis.2014.11.011. Epub 2014 Nov 18. doi: 10.1152/ajpheart.00494.2014. Epub 2014 Oct 3. doi: 10.1016/j.kjms.2014.04.005. Epub 2014 May 28. doi: 10.1016/j.jss.2014.03.004. Epub 2014 Mar 11. doi: 10.1016/j.neuroscience.2014.06.043. Epub 2014 Jun 30. doi: 10.1152/ajpregu.00082.2016. Epub 2016 Mar 23.

    合成参考文献


    参考文献:10.1007/bf01310746
    摘要:Grinde B, Hungnes O, Tjøtta E. Modified oligopeptides designed to interact with the HIV-1 proteinase inhibit viral replication. Arch Virol. 1990;114(3-4):167–73. doi: 10.1007/bf01310746.
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