CAS: 210169-54-3; (S)-5,5'-Bis(Diphenylphosphino)-4,4'-Bi-1,3-Benzodioxole

上下游产品

(+/-)-(4,4'-Bi-1,3-Benzodioxole)-5,5'-Diyl-Bis(Diphenylphosphine Oxide)

Benzo[d][1,3]Dioxol-5-Yldiphenylphosphine Oxide置于titanium(Iv) Isopropylate,乙二醇二甲醚,酞菁钴,四(二甲氨基)乙烯,(S)-4-叔丁基-2-(2-氮苯基)恶唑啉,Lithium Diisopropyl Amide体系中,用 四氢呋喃,1,4-二氧六环,正己烷 用作溶剂,化学反应 50.0H,反应生成(S)-(-)-5,5-双(二苯膦基)-4,4-双-1,3-苯并间二氧杂环戊烯
参考文献:通过镍催化不对称 Ullmann 耦合合成轴向手性 2,2'-双磷酸二烯:在没有光学分辨率的情况下获得特权手性配体的一般途径
标题:通过镍催化不对称 Ullmann 耦合合成轴向手性 2,2'-双磷酸二烯:在没有光学分辨率的情况下获得特权手性配体的一般途径
摘要:我们报告了邻-(碘) 芳基膦氧化物和邻-(碘) 芳基膦酸盐的不对称同源偶联,导致高度对映体富集的轴向手性双膦氧化物和双膦酸盐.这些产品很容易转化为对映体富集的联芳基双膦,无需手性助剂或光学拆分.这为开发以前未研究的阻转选择性联芳基双膦配体提供了一条实用的途径.这些条件也被证明对其他不含磷的芳基卤化物的不对称二聚化有效.
Doi:10.1021/jacs.0C12843

专利信息

专利号:US-11999757-B2
优先权日:2017-11-01
标 题:Synthesis of boronate ester derivatives and uses thereof
发明人：BOYER SERGE HENRI; HECKER SCOTT J; VERZIJL GERARDUS K M; HERMSEN PETRUS J
权利人:MELINTA SUBSIDIARY CORP
摘要:Disclosed herein are methods for the preparation of boronate derivatives in the synthesis of antimicrobial compounds and uses thereof. Disclosed herein includes method of making a compound of Formula (B) by reducing the ketone group of the keto-ester compound of Formula (A), and the reduction can be performed using a Ruthenium based catalyst system or using an alcohol dehydrogenase bioreduction system.

专利号:US-2025101006-A1
优先权日:2022-01-31
标题:Process for the synthesis of pyrazolyl derivatives useful as anti-cancer agents
发明人：BAENZIGER MARKUS; GALLOU FABRICE; GUO FENGFENG; HÄNGGI RUDOLF; HAN ENJIAN; JORDINE GUIDO; LI JIALIANG; LIU WEIPENG; MIAO BUKEYAN; RONG SHAOFENG; SANTANDREA ERNESTO; SCHIRNER PAUL BERND; SHEN XIAODONG; WANG CAN; ZHANG HAO
权利人:NOVARTIS AG
摘要:The invention provides a novel process, novel process steps and novel intermediates useful in the synthesis of pharmaceutically active compounds, especially KRAS G12C inhibitors. The present invention provides a direct enantioselective chemical manufacturing method of making Compound A, or a pharmaceutically acceptable hydrate or solvent thereof: (I). The invention provides a process for preparing Intermediate B6* comprising reacting Intermediate B4* with Intermediate B5* in an atroposelective coupling reaction, using a chiral catalyst.

专利号:US-10745354-B2
优先权日:2017-11-01
标题 :Methods for enantioselective allylic alkylation of esters, lactones, and lactams with unactivated allylic alcohols
发明人：STOLTZ BRIAN M; NGAMNITHIPORN AURAPAT; JETTE CARINA I; BACHMAN SHOSHANA; VIRGIL SCOTT C; LACKNER SEBASTIAN
权利人:CALIFORNIA INST OF TECHN
摘要:The present disclosure provides methods for enantioselective synthesis of cyclic and acyclic α-quaternary carboxylic acid derivatives via nickel-catalyzed allylic alkylation.

专利号:US-8729306-B2
优先权日:2010-02-05
标 题:Process for the preparation of nitrogen substituted aminotetralins derivatives
发明人：VASSELIN DAVID; CARLY NICOLAS; ATES CELAL
权利人:VASSELIN DAVID; CARLY NICOLAS; ATES CELAL; UCB PHARMA GMBH
摘要:The present invention provides an alternative synthesis of N-substituted aminotetralines which synthesis comprises catalytic asymmetric hydrogenation of compounds of general formula (A).

专利号:US-2022064111-A1
优先权日:2019-01-17
标 题:Enantioselective synthesis of brivaracetam and intermediates thereof
发明人：ROY SARABINDU; GHOSH ANGSHUMAN; KUBEER RAMESH DHONDI; PRASAD MUTYALA V V VARA; PAUL GOPAL; GARAI ABHISHEK; CHAKRABORTY SOURAV; HALDAR ANIMESH; YADAW AJAY KUMAR; ROY SUBHO
权利人:CLININVENT RES PVT LTD
摘要:The present invention relates to an improved and economical process for enantioselective synthesis and purification of a novel key intermediate of Brivaracetam. Further, the present invention also relates to a process for the preparation of a chirally pure Brivaracetam of formula I utilizing the said intermediate.

专利号:US-2024199569-A1
优先权日:2022-11-30
标 题:Process for the manufacture of inhibitors of kras
发明人：ZHANG YONGDA; CHONG EUGENE; REEVES JONATHAN TIMOTHY; WHITE JADA A H; LEI ZHEN
权利人:BOEHRINGER INGELHEIM INT
摘要:This invention relates to an efficient and enantioselective synthesis of the spiro-compounds of formula (1) as common intermediate, featuring an asymmetric introduction of the all-carbon quaternary centre in high selectivity and a very efficient one-pot procedure for the C2 elongation to generate the spiro-structure.For the all-carbon quaternary centre, a Tsuji-Trost asymmetric allylic alkylation (AAA) process was designed to develop a sustainable procedure with very low catalyst loading, thereby also facilitating the Pd content control in the product, under practically solvent free conditions. Furthermore, multiple synthetic transformations in a one-pot procedure were implemented by using a one-pot procedure either in form of a three-transformation sequence comprising Hydroboration-Alkylation-Dieckmann Condensation to compound of formula (1) or in form of a five-transformation sequence comprising Hydroboration-Alkylation-Dieckmann Condensation-Hydrolysis-Decarboxylation to compound of formula (9).