CAS: 161696-76-0; N-Desmethylolanzapine

相似化合物

174794-02-6 138564-60-0 1977-07-7

上下游产品

piperazine 4-amino-2-methyl-10H-thieno[2,3-b][1,5]benzodiazepine hydr°Chloride ortho-nitrofluorobenzene 2-(2-nitroanilino)-5-methylthiophene-3-carbonitrile zyprexa

📜奥氮平置于cytochrome P450 1A2体系中,化学反应生成2-甲基-4-(1-哌嗪基)-10H-噻吩并[2,3-B][1,5]苯并二氮杂卓
参考文献:Butyl Methacrylate-Co-Ethylene Glycol Dimethacrylate Monolith For Online In-Tube Spme-UHPLC-Ms/ms To Determine Chlopromazine,Clozapine,Quetiapine,Olanzapine,And Their Metabolites In Plasma Samples
标题:Butyl Methacrylate-Co-Ethylene Glycol Dimethacrylate Monolith For Online In-Tube Spme-UHPLC-Ms/ms To Determine Chlopromazine,Clozapine,Quetiapine,Olanzapine,And Their Metabolites In Plasma Samples
摘要:这篇手稿描述了一种敏感,选择性和在线管内固相微萃取结合超高效液相色谱-串联质谱(管内spme-UHPLC-Ms/ms)方法,用于测定精神分裂症患者血浆样本中氯丙嗪,氯氮平,奎硫平,奥氮平及其代谢物的含量.有机聚合物(丁基甲基丙烯酸酯-乙二醇二甲基丙烯酸酯共聚物)单体在熔融二氧化硅毛细管的内表面上合成(共价键),用于管内spme.通过将单体毛细管连接到uHPLC-Ms/ms系统进行样品提取和分析.单体通过扫描电子显微镜(sem)和傅里叶变换红外光谱仪(ftir)进行表征.开发的方法对所有目标抗精神病药物均具有适当的线性关系:R2高于0.9975,缺乏拟合范围为0.115至0.955,精密度的变异系数低于14.2%,准确度的相对标准误差值范围为-13.5%至14.6%,除了定量下限(lloq).血浆样本中的lloq值为10 Ng Ml−1.该方法成功应用于测定精神分裂症患者血浆样本中的抗精神病药物及其代谢物.
Doi:10.3390/molecules24020310

专利信息

专利号:WO-2005070939-A1
优先权日:2004-01-27
标 题:Synthesis of olanzapine and intermediates thereof
发明人：KELTJENS ROLF; PETERS THEODORUS HENDRICUS ANT
权利人:SYNTHON BV; KELTJENS ROLF; PETERS THEODORUS HENDRICUS ANT
摘要:Olanzapine and salts thereof are made by a process that utilizes an N-formyl olanzapine intermediate of formula (4) or a salt thereof.

专利号:US-2005267099-A1
优先权日:2004-01-27
标题:Synthesis of olanzapine and intermediates thereof

专利号:CA-2558654-A1
优先权日:2004-03-18
标 题:Synthesis of 2-methyl-4-(4-methyl-1-piperazinyl)-10h-thieno[2, 3-b][1,5]benzodiazepine and salts thereof

专利号:US-2008161557-A1
优先权日:2004-03-18
标 题:Synthesis of 2-Methyl-4-(4-Methyl-1-Piperazinly)-10H-Thieno(2,3-B) (1,5) Benzodiazepine and Salts Thereof

专利号:US-7329747-B2
优先权日:2004-01-27
标 题:Synthesis of olanzapine and intermediates thereof

专利号:AU-2005223338-A1
优先权日:2004-03-18
标题:Synthesis of 2-methyl-4-(4-methyl-1-piperazinyl)-10h-thieno(2, 3-b)(1,5)benzodiazepine and salts thereof