CAS: 161532-65-6; 4-[4-[4-[4-[[(3R,5R)-5-(2,4-Difluorophenyl)-5-(1,2,4-Triazol-1-Ylmethyl)Oxolan-3-Yl]Methoxy]Phenyl]Piperazin-1-Yl]Phenyl]-2-Pentan-3-Yl-1,2,4-Triazol-3-One
该化合物具有多功能结构的复杂有机化合物,包括支聚醇骨干和有助于其生物活动的各种替代成分.由于已知三联苯基衍生物在这些地区的功效,二氟苯基苯基化合物组可能提高亲性与生物相互作用,而氟芳基磺酰胺会影响受体的约束性和药理学应用.这种化合物的精度和药性特性将决定其精度和化学特性的精密性特性的特性将决定其精密性化学特性的特性,使其成为其精密性化学合成的化学特性的精度和精准特性的精度的精度.
- 英文名称4-[4-[4-[4-[[(3R,5R)-5-(2,4-Difluorophenyl)-5-(1,2,4-Triazol-1-Ylmethyl)Oxolan-3-Yl]Methoxy]Phenyl]Piperazin-1-Yl]Phenyl]-2-Pentan-3-Yl-1,2,4-Triazol-3-One
- 中文名称泊沙康唑杂质39
- IUPAC名称(-)-cis-4-(4-(4-(4-(5R-(2,4-Difluorophenyl)-5-(1,2,4-triazol-1-ylmethyl)tetrahydrofuran-3R-ylmethoxy)phenyl)piperazin-1-yl)phenyl)-2-(1-ethylpropyl)-3,4-dihydro-2H-1,2,4-triazol-3-one
- CAS编号161532-65-6
- FDA UNII编号:ZVW2AK6BVY
- 分子式:C37H42F2N8O3分子量:684.79
- 产品CID: 815590
- 产品分类分析化学 → 标准品 → 药典标准品和杂质标准品
物理性质
MSDS等安全信息
合成工艺路线路线简述
海关参考信息
- 2902600000-乙苯
2902700000-异丙基苯
2905122000-异丙醇
2905399001-1,3-丙二醇 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
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供应商参考报价(招募中)
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📌 第三方产品分析报告
主要参考文献
1: Nomeir AA, Pramanik BN, Heimark L, Bennett F, Veals J, Bartner P, Hilbert M, Saksena A, McNamara P, Girijavallabhan V, Ganguly AK, Lovey R, Pike R, Wang H, Liu YT, Kumari P, Korfmacher W, Lin CC, Cacciapuoti A, Loebenberg D, Hare R, Miller G, Pickett C. Posaconazole (Noxafil, SCH 56592), a new azole antifungal drug, was a discovery based on the isolation and mass spectral characterization of a circulating metabolite of an earlier lead (SCH 51048). J Mass Spectrom. 2008 Apr;43(4):509-17. Bioorg Med Chem Lett. 2006 Jan 1;16(1):186-90.
5: Clemons KV, Homola ME, Stevens DA. Activities of the triazole SCH 51048 against Coccidioides immitis in vitro and in vivo. Antimicrob Agents Chemother. 1995 May;39(5):1169-72.
6: Sugar AM, Picard M. Treatment of murine pulmonary blastomycosis with SCH 51048, a broad-spectrum triazole antifungal agent. Antimicrob Agents Chemother. 1995 Apr;39(4):996-7.
合成参考文献
参考文献:10.1016/s0960-894x(02)00282-2
摘要:Lovey RG, Saksena AK, Girijavallabhan VM, Blundell P, Guzik H, Loebenberg D, Parmegiani RM, Cacciapuoti A. Synthesis and antifungal activity of the 2,2,5-tetrahydrofuran regioisomers of SCH 51048. Bioorganic & Medicinal Chemistry Letters. 2002 Jul;12(13):1739–42. doi: 10.1016/s0960-894x(02)00282-2.
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