CAS: 156270-06-3; 1H-Pyrrolo[2,3-B]Pyridine-3-Carboxylicacid

相似化合物

808137-94-2 4649-09-6 4414-89-5

上下游产品

CAS号4649-09-6 7-氮杂吲哚-3-甲醛 | CAS号163220-69-7 2,2,2-三氯-1-(1H-... | CAS号4414-89-5 3-氰基-7-氮杂吲哚 | CAS号269726-49-0 5-氨基-1-(叔丁基)-1H... | CAS号269726-48-9 N-tert-butylami... | CAS号269726-50-3 1-(叔丁基)-1H-吡咯并[... | CAS号271-63-6 7-氮杂吲哚 | CAS号76-02-8 三氯乙酰氯 | CAS号808137-94-2 7-氮杂吲哚-3-甲酸甲酯

3-氰基-7-氮杂吲哚置于盐酸,Aluminum (III) Chloride,水体系中,化学反应 48.0H,反应生成1H-吡咯并[2,3-B]吡啶-3-甲酸
参考文献:7-氮杂吲哚羧基-内-托帕那酰胺的实用合成 (Df 1012)
标题:7-氮杂吲哚羧基-内-托帕那酰胺的实用合成 (Df 1012)
摘要:特此报道了一种新的镇咳药物 Df1012 的优化成本效益合成.关键中间体df1005的新合成路线是基于1-叔丁基-3-氰基-7-氮杂吲哚中间体的特殊脱保护步骤,这也可以看作是昂贵7的工业化生产的便捷途径-Azaindole 1. 第二个关键中间体,Endo-Tropanamine 6,是通过使用 Pd 催化的还原胺化过程的新型一锅立体选择性工艺以高产率获得的.
Doi:10.1021/op025570T

专利信息

专利号:US-2012245199-A1
优先权日:2009-12-23
标题:[4 [4-(aminomethyl-2-fluoro-phenyl)-piperidin-1-yl]-(1h-pyrrolo-pyridin-yl)-methanones and synthesis thereof
发明人：CHOI-SLEDESKI YONG MI; NIEDUZAK THADDEUS R; POLI GREGORY B; SHUM PATRICK WAI-KWOK; STOKLOSA GREGORY T; ZHAO ZHICHENG
权利人:CHOI-SLEDESKI YONG MI; NIEDUZAK THADDEUS R; POLI GREGORY B; SHUM PATRICK WAI-KWOK; STOKLOSA GREGORY T; ZHAO ZHICHENG; SANOFI SA
摘要:The present invention relates herein to compounds and compositions for the treatment and amelioration of inflammatory disease. Specifically the present invention relates to compounds that having a tryptase inhibition activity and the intermediates thereof, pharmaceutical compositions comprising such compounds, and a method of treating subjects suffering from a condition disease or disorder that can be ameliorated by the administration of an inhibitor of tryptase.

专利号:CN-105218546-A
优先权日:2015-11-04
标 题:Synthesis of 1H-pyrrolo[2,3-B]pyridine-3-carboxylate methyl ester

专利号:MX-PA03003624-A
优先权日:2000-10-27
标题 :7-AZAINDOLES, ITS USE AS INHIBITORS OF THE 4 PHOSPHODIESTERASE, AND A METHOD FOR THE SYNTHESIS OF THE SAME.

专利号:CN-105218546-B
优先权日:2015-11-04
标 题 :Synthesis process of 1H-pyrrolo[2,3-B] pyridine-3-carboxylic methyl ether