CAS: 134604-07-2; 1-Cyano-2-Bromo-5-Nitrobenzene

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CAS号17420-30-3 2-氰基-4-硝基苯胺 | CAS号106-95-6 烯丙基溴 | CAS号619-24-9 间硝基苯腈 | CAS号2042-37-7 邻溴苯腈 | CAS号7697-37-2 硝酸 | CAS号10496-75-0 2-甲氧基-5-硝基苯甲腈 | CAS号856167-67-4 5-溴-2-异丁基苯甲腈

间硝基苯腈置于n-溴代丁二酰亚胺(Nbs),Palladium Diacetate,对甲苯磺酸体系中,用 1,2-二氯乙烷 用作溶剂,化学反应 12.0H,以84%的收率获得2-溴-5-硝基苯甲腈
参考文献:Palladium-Catalyzed Highly Selective Ortho-Halogenation (I,Br,Cl) Of Arylnitriles Via Sp2 C-h Bond Activation Using Cyano As Directing Group
标题:Palladium-Catalyzed Highly Selective Ortho-Halogenation (I,Br,Cl) Of Arylnitriles Via Sp2 C-h Bond Activation Using Cyano As Directing Group
摘要:A Palladium-Catalyzed Ortho-Halogenation (I,Br,Cl) Of Arylnitrile Is Described. The Optimal Reaction Conditions Were Identified After Examining Various Factors Such As Catalyst,Additive,Solvent,And Reaction Temperature. Using Cyano As The Directing Group,The Halogenation Reaction Gave Good To Excellent Yields. The Method Is Compatible To The Arylnitriles With Either Electron-Withdrawing Or Electron-Donating Groups. The Reaction Is Available To The Substrate In At Least Gram Scale. The Present Method Was Successfully Applied To The Synthesis Of The Precursors Of Paucifloral F And Isopaucifloral F.
Doi:10.1021/jo302765G