CAS: 129648-07-3; (2R,5R)-1-[2-[(2R,5R)-2,5-Dimethylphospholan-1-Yl]Ethyl]-2,5-Dimethylphospholane

上下游产品

CAS号34338-96-0 (2S,5S)-2,5-己二醇 | CAS号6315-52-2 亚乙基二(p-甲苯磺酸盐)

📜(S,S)-2,5-Bis(Methylsulfonyloxy)Hexane置于lithium体系中,用 四氢呋喃 用作溶剂,化学反应 28.0H,反应生成(+)-1,2-双((2R,5R)-2,5-二乙磷酰亚基)苯
参考文献:新的手性膦酸酯;合成,表征及其在不对称氢化反应中的用途
标题:新的手性膦酸酯;合成,表征及其在不对称氢化反应中的用途
摘要:我们描述了对映体纯的反式-2,5-二取代-1-苯基膦酸酯的实际合成,然后将其用于制备一系列新的c 2对称双-和c 3对称三(膦)配体.概述了用于膦合成的重要手性1,4-二醇中间体的通用三步路线.制备了带有新的膦配体的铑配合物,并显示出它们可作为对各种不饱和底物进行对映选择性氢化的有效催化剂前体.
Doi:10.1016/s0957-4166(00)86109-1

专利信息

专利号:EP-3800178-A1
优先权日:2019-10-01
标题:Preparation of enamide intermediate for the synthesis of dasotraline
发明人：BALLETTE ROBERTO; DOBARRO RODRÃ?GUEZ ALICIA
权利人:MOEHS IBERICA SL
摘要:The present invention relates to a process for the preparation of N -(( S )-4-(3,4-dichlorophenyl)-3,4-dihydronaphthalen-1-yl)acetamide, which is a suitable intermediate for the synthesis of dasotraline or a pharmaceutically acceptable salt thereof, as well as to a process for the preparation of dasotraline or a pharmaceutically acceptable salt thereof using said N -(( S )-4-(3,4-dichlorophenyl)-3,4-dihydronaphthalen-1-yl)acetamide intermediate.

专利号:US-6753289-B2
优先权日:2001-06-04
标 题:One-step production of 1,3-propanediol from ethylene oxide and syngas with a catalyst with a phospholanoalkane ligand
发明人：KNIFTON JOHN FREDERICK; JAMES TALMADGE GAIL; ALLEN KEVIN DALE; WEIDER PAUL RICHARD; POWELL JOSEPH BROUN; SLAUGH LYNN HENRY
权利人:SHELL OIL CO
摘要:Disclosed is a novel class of modified ruthenium catalysts useful in the one step synthesis of 1,3-PDO comprising (a) a cobalt component comprising one or more non-ligated cobalt compounds; and (b) a ruthenium component comprising in major part a ruthenium carbonyl compound ligated with a phospholanoalkane ligand, solubilized in an ether solvent, that provides potential improvements in cost and performance in one step hydroformylation/hydrogenation. For example, cobalt-ruthenium-bidentate, bis(phospholano)alkane catalyst precursors in ether solvents provide good yields of 1,3-PDO in a one step synthesis.

专利号:US-7456320-B2
优先权日:2004-02-19
标题:Process for the synthesis of substituted alpha-aminoindan derivatives
发明人：BERTRAND BLANDINE; BLANCHET SYLVIE; BURGOS ALAIN; MARTIN JULIETTE; PERRIN FLORENCE; ROUSSIASSE SONIA; DERRIEN YVON
权利人:ZACH SYSTEM
摘要:A process for the preparation of optically active substituted alpha-amino-indane derivatives of formula (I), which include: an asymmetric hydrogenation reaction of an en-amide derivative of formula (III) in presence of hydrogen and an optically active catalyst, in order to obtain an amide derivative of formula (II), a hydrolysis reaction of the amide derivative of formula (II) obtained in the previous step, n in order to obtain optically active substituted alpha-amino-indane derivatives of formula (I).

专利号:US-7115540-B2
优先权日:2002-02-13
标题 :Synthesis of aliphatic 1,3-diols utilizing reduced ligand concentration and water extraction
发明人：POWELL JOSEPH BROUN; WEIDER PAUL RICHARD; KNIFTON JOHN FREDERICK; ALLEN KEVIN DALE; SLAUGH LYNN HENRY; ARHANCET JUAN PEDRO
权利人:SHELL OIL CO
摘要:This invention is a process for synthesizing aliphatic 1,3-diols in one step by hydroformylation and hydrogenation of oxirane, carbon monoxide, and hydrogen employing a catalyst comprising a cobalt carbonyl compound and a cocatalyst metal compound ligated with a ligand in a ligand to cocatalyst metal atom molar ratio in the range of 0.2:1.0 to 0.6:1.0, optionally in the presence of a promoter, where recovery of product is preferably accomplished via water extraction of a diol rich phase from the bulk reaction mixture. The process modifications can, particularly in combination, be beneficial with respect to product recovery, catalyst recycle, and overall economics of a one-step process for producing aliphatic 1,3-diols.

专利号:US-9126906-B2
优先权日:2012-02-21
标 题:Asymmetric synthetic processes for the preparation of aminosulfone compounds
发明人：CONNOLLY TERRENCE J; RUCHELMAN ALEXANDER L; LEONG WILLIAM W
权利人:CELGENE CORP
摘要:Processes for synthesizing aminosulfone compounds are provided. The processes provided herein utilize asymmetric reduction reactions, e.g., asymmetric hydrogenation, of protected or unprotected enamine or ketone substrates. Aminosulfone compounds obtained using methods provided herein are useful in production or synthesis of sulfone group containing isoindoline based compounds.

专利号:US-7579487-B2
优先权日:2004-05-11
标 题 :Process for making N-sulfonated-amino acid derivatives
发明人：DREHER SPENCER D; IKEMOTO NORIHIRO; SHULTZ C SCOTT; WILLIAMS J MICHAEL
权利人:MERCK & CO INC
摘要:This invention relates to a process for preparing optically active α-amino acid substrates which are used to make potent lethal factor (LF) inhibitors for the treatment of anthrax. This invention further relates to a process for synthesis of potent LF-inhibitors for the treatment of anthrax. Specifically, the invention concerns a novel, high-yielding and highly enantioselective asymmetric hydrogenation reaction of a tetrasubstituted ene-sulfonamide acid or ester.