CAS: 1141-06-6; 2-Hydroxy-1,2-Di(Pyridin-2-yl)Ethanone

该化合物是有机化合物,其独特的结构特征包括两个环和附属于一个埃太酮骨柱的氢基基,该化合物具有典型的氯酮和苯基化合物特性,有助于其在各种化学环境中的潜在反应和应用;已知该化合物具有切热金属离子的能力,因为它在环中存在氮原子,使其在协调化学和可能的催化方面有用;氢氧基组可以参与氢结合,影响其溶解性和与其他分子的相互作用;此外,该化合物可能展示生物活动,这可能会引起药物研究的兴趣;其稳定性和再活性可能因环境条件而不同,例如pH和温度,这些环境是其实际应用中的重要考虑因素.

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492-73-9 59576-32-8 95195-43-0

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CAS号1121-60-4 吡啶-2-甲醛 | CAS号292638-85-8 丙烯酸甲酯 | CAS号109-06-8 2-甲基吡啶 | CAS号492-73-9 2,2′-吡啶酮 | CAS号524-67-4 2-diazo-1,2-di-... | CAS号98-88-4 苯甲酰氯 | CAS号586-98-1 吡啶甲醇 | CAS号492-73-9 2,2′-吡啶酮 | CAS号98-98-6 2-吡啶甲酸 | CAS号91396-93-9 2-Pyridinecarbo... | CAS号23309-74-2 Quinoxaline,2,3... | CAS号25005-97-4 四-2-吡啶基吡嗪 | CAS号1121-60-4 吡啶-2-甲醛 | CAS号19437-26-4 2-二吡啶基酮

合成工艺路线路线简述

    📜吡啶-2-甲醛置于tea,N,N'-二甲基苯并咪唑鎓碘化物体系中,用 甲醇 用作溶剂,化学反应 1.0H,以70%的收率获得吡咯酮
    参考文献:Catalytic Action Of Azolium Salts. Vi. Preparation Of Benzoins And Acyloins By Condensation Of Aldehydes Catalyzed By Azolium Salts.
    标题:Catalytic Action Of Azolium Salts. Vi. Preparation Of Benzoins And Acyloins By Condensation Of Aldehydes Catalyzed By Azolium Salts.
    摘要:苯偶姻 4(在 1-和 2-位置上带有芳基取代的 2-羟基乙酮)通过使用少量的唑盐 1 和 2 作为催化剂,由芳香醛 3 的自缩合反应高效制备得到.1,3-二甲基苯并咪唑碘盐(2)是制备乙偶姻 6(在 1-和 2-位置上带有烷基取代的 2-羟基乙酮)的有效催化剂,通过脂肪醛 5 的自缩合反应实现.另一方面,使用 1,3-二甲基咪唑碘盐(1)催化己醛(5D)的缩合反应未能得到乙偶姻 6D,而是得到了醛醇型缩合产物 8D.
    Doi:10.1248/cpb.42.2633

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    专利信息


    专利号:WO-2023070903-A1
    优先权日:2021-10-28
    标 题 :Aromatic aldehyde condensation method
    发明人：LI RONGRONG; WANG DEHUA; CHEN XIANLANG; HAN DEMAN; WU CHENGLIN; YING XIA
    权利人:UNIV TAIZHOU; TAIZHOU BIOMEDICAL AND CHEMISTRY INDUSTRY RES INSTITUTE CO LTD
    摘要:The present invention relates to the technical field of organic synthesis, and provides an aromatic aldehyde condensation method. The condensation method provided by the present invention comprises the following step: performing condensation reaction on aromatic aldehyde and a condensation mixing reagent in a micro-channel reactor to obtain an ester compound, the condensation mixing reagent comprising a phase transfer catalyst, sodium cyanide, ethanol, and water. The condensation reaction of the present invention is performed in the micro-channel reactor, and the specific surface area of the micro-channel reactor is large, such that materials can be in full contact, the reaction is complete, the generation of byproducts is reduced, and the yield of a product is further improved. Experimental data of embodiments shows that: in the condensation method provided by the present invention, the ester compound has a conversion rate of 98.4% and selectivity of 98.4%.

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    主要参考文献

    参考标题:New Route To Synthesis Of Unexpected Pyridoin Derivatives: Their Structure Determination With Spectroscopic And X-Ray Methods
    作者:Alaaddin Cukurovali |发布日期:2009.11.18
    摘要:New 1,2,4-Triazine-3-Thione Derivatives Were Obtained By A New Route Using A One-Step Process. The Structure Of The Compounds Was Determined With Infrared (Ir), 1H Nmr, And 13C Nmr Spectroscopic Methods And Elemental Analysis. A Representative X-Ray Crystallographic Analysis Of 3 Was Given, And Its X-Ray Data Are Discussed In Detail. This Is A Facile Procedure And Shorter Than Earlier Methods.

    合成参考文献


    摘要:Sato, N., Science of Synthesis, (2004) 16, 756.
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