CAS: 112204-57-6; (5-Bromo-2-Fluorophenyl)Boronic Acid
该化合物是一种有机体化合物,其特点是苯环上含有溴和氟替代物,以及一个碳酸功能组,其分子结构中含有一种与氢氧化物组和芳香环结合的原原生原子,这增强了其在各种化学反应中的抗反应性,特别是在铃木合金反应中,一种形成碳-碳联结的共同方法;溴和氟原子的存在有助于其独特的电子特性,使它成为有机合成和药用化学中有价值的中间体.该化合物通常是白色至白外固体,在极地有机溶剂中可溶解.重要的是要谨慎地处理它,因为烟酸可能对湿气和空气敏感,可能影响其稳定性和再活动.此外,由于卤化化合物的潜在毒性,应当采取安全防范措施.
- 英文名称(5-Bromo-2-Fluorophenyl)Boronic Acid
- 中文名称(5-溴-2-氟苯基)硼酸
- IUPAC名称(5-bromo-2-fluorophenyl)boronic acid
- 其它别名5-溴-2-氟苯基硼酸; 5溴2氟苯硼酸; 5-Bromo-2-Fluorophenylboronic Acid
- CAS编号112204-57-6
- MFCD编号:MFCD05664307
- EINECS号:687-900-2
- 分子式:C6H5BBrFO2分子量:218.82
- 产品CID: 155810
- 产品分类有机原料→分子砌块→芳环类化合物→苯类化合物
相似化合物
352535-97-8 352535-84-3 2096331-76-7物理性质
MSDS等安全信息
- GHS象形图
- GHS符号GHS07;
注释: Exclamation mark - 危险类别皮肤腐蚀/刺激 类别2
严重眼刺激 类别2
特定目标器官毒性 - 单次接触 类别3
急性毒性 类别4(经口)
严重眼刺激 类别2A - 警示词Warning(警告)
- 危险描述H315 |造成皮肤刺激.
H319 |造成严重眼刺激.
H335 |可能引起呼吸道刺激.
H302 |吞咽有害. - 防范说明P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501
- 危险等级IRRITANT, KEEP COLD
- UN编号NONH for all modes of transport
- 危险品标志Xi
- 风险等级Irritant/Keep Cold
- 安全声明H303May be harmful if swallowed+H313Skin contact may be harmful+H333Inhalation may be harmful to the body
- WGK Germany3
欧盟法规
C&L通报上下游产品
CAS号768-66-1 2,2,6,6-四甲基哌啶 | CAS号460-00-4 对氟溴苯 | CAS号5419-55-6 硼酸三异丙酯 | CAS号121-43-7 硼酸三甲酯 | CAS号2369-37-1 1,2-二溴-4-氟苯 | CAS号1435-53-6 2,4-二溴氟苯 | CAS号112204-58-7 5-溴-2-氟苯酚合成工艺路线路线简述
📜(5-Bromo-2-Fluorophenyl)-Dimethoxyborane置于溶剂黄146体系中,用 四氢呋喃,Hexanes 用作溶剂,化学反应 0.5H,反应生成5-溴-2-氟苯硼酸
参考文献:Wo2006/76246
标题:Wo2006/76246
专利信息
专利号:US-9834551-B2
优先权日:2013-04-18
标 题 :Substituted pyrrolo[2,3-b]pyrazines and substituted pyrazolo[3,4-b]pyridines as ITK and JAK kinase inhibitors
发明人：VANKAYALAPATI HARIPRASAD; YERRAMREDDY VENKATAKRISHNAREDDY; GANGIREDDY PARAMAREDDY; APPALANENI RAJENDRA P
权利人:ARRIEN PHARMACEUTICALS LLC
摘要:The present invention relates to compounds described by Formula I: n nsalts thereof, their synthesis, and their use as ITK and JAK3 inhibitors including such compounds and methods of using said compounds in the treatment of various diseases and or disorders such disease associated with abnormal cell growth such as autoimmune, inflammation, rheumatoid arthritis, systemic lupus erythematosus, atherosclerosis, ulcerative colitis, psoriatic arthritis, psoriasis, Crohn's, metabolic and cancer diseases. The present invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions and processes for preparing the compounds of the invention.
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
合成参考文献
参考文献:10.1055/s-0037-1609518
摘要:Synthesis of Verubecestat. Synfacts. 2018 May 17;14(06):0555. doi: 10.1055/s-0037-1609518.
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