CAS: 1112-67-0; Tetrabutylammonium Chloride

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CAS号2052-49-5 四丁基氢氧化铵 | CAS号1923-70-2 四正丁基高氯酸铵 | CAS号554-68-7 三乙胺盐酸盐 | CAS号3674-54-2 四丁基硫氰酸铵 | CAS号429-41-4 四丁基氟化铵 | CAS号3109-63-5 四丁基六氟磷酸铵 | CAS号94-18-8 4-羟基苯甲酸苯甲酯 | CAS号56442-22-9 间(苯基甲氧基)苯甲酸苯基甲基酯 | CAS号1860-44-2 11-氯代癸酸 | CAS号19950-87-9 5-chloro-3-(4-c... | CAS号103-26-4 肉桂酸甲酯 | CAS号3650-78-0 4-溴肉桂酸甲酯

四丁基氢氧化铵置于[(Cy3P)2Pd(Cl)Ph],水体系中,用 四氢呋喃 用作溶剂,化学反应生成四丁基氯化铵
参考文献:区分 Suzuki-Miyaura 反应中转金属化的途径
标题:区分 Suzuki-Miyaura 反应中转金属化的途径
摘要:我们报告了对分离的芳基钯羟基和卤化物与芳基硼酸和芳基三羟基硼酸盐的化学计量反应的系统研究,以评估通常提出的用于解释 Suzuki-Miyaura 反应中金属转移的两种反应途径的相对速率.根据在催化过程常见条件下生成的钯和有机硼物种的相对种群以及观测到的两类反应组分之间化学计量反应的速率常数,我们得出结论,钯羟基络合物与硼的反应酸,而不是卤化钯配合物与三羟基硼酸盐的反应,在用弱碱和水性溶剂混合物进行的催化 Suzuki-Miyaura 反应中解释了金属转移.
Doi:10.1021/ja1108326

专利信息

专利号:WO-2022256490-A9
优先权日:2021-06-03
标题:Improved synthesis of phosphoramidates for the treatment of hepatitis b virus
发明人：LOCKWOOD MARK
权利人:ANTIOS THERAPEUTICS INC
摘要:The synthesis of phosphoramidate prodrugs useful in the treatment of viral infections is disclosed. Specifically, an improved synthesis of phosphoramidate nucleotides useful in the treatment of Hepatitis B virus is disclosed.

专利号:US-7230101-B1
优先权日:2002-08-28
标 题:Synthesis of methotrexate-containing heterodimeric molecules
发明人：MURTHI KRISHNA K; SMITH CHASE C
权利人:GPC BIOTECH INC
摘要:The present invention relates to novel compositions of methotrexate-containing heterodimeric probe molecules, also known as chemical inducers of dimerization (CID), useful in three-hybrid assays. The invention further relates to synthesis of said compositions and their intermediates. Another aspect of the invention is a method for using the heterodimeric probe molecules described herein in drug screens to identify potential protein targets to a given ligand, optimize protein-ligand interactions, or identify potential ligands for a given protein target. In certain embodiments, the invention contemplates the synthesis of the following methotrexate-containing heterodimeric probe:

专利号:US-11639349-B2
优先权日:2020-05-28
标题:Stereoselective synthesis of intermediate for preparation of heterocyclic compound
发明人：CHEN WEN-CHANG; HSU HAN-PEI; CHOU SHAN-YEN; CHUANG SHIH-CHIEH; YEN CHI-FENG
权利人:TAI GEN BIOTECHNOLOGY CO LTD; TAIGEN BIOPHARMACEUTICALS CO BEIJING LTD; TAIGEN BIOTECHNOLOGY CO LTD
摘要:Provided is a stereoselective synthesis of an intermediate for the preparation of the heterocyclic derivative as a Cap-dependent endonuclease inhibitor. The synthesis process has the advantages of simple operation, higher yield and relatively controllable steroselectivity, such that it is suitable for large-scale production.

专利号:US-7199257-B1
优先权日:1999-06-10
标题 :Process for the synthesis of N-(4-cyano-3-trifluoromethylphenyl)-3-(4-fluorophenylsulfonyl)-2-hydroxy-2-methylpropionamide
发明人：SOEROES BELA; TUBA ZOLTAN; GALIK GYOERGY; BOR ADAM; DEMETER ADAM; TRISCHLER FERENC; HORVATH JANOS; BRLIK JANOS
权利人:RICHTER GEDEON VEGYESZET
摘要:A new process is disclosed for the synthesis of racemic or optically pure N-[4-cyano-3-trifluoro-methyl-phenyl]-3[4-fluorophenyl-sulfonyl]-2-hydroxy-2-methylpropionamide. The process includes the formation of several novel intermediates in the synthesis.

专利号:US-2012215002-A1
优先权日:2009-10-09
标 题:Synthesis of optically active intermediate for the preparation of montelukast
发明人：LEFORT LAURENT
权利人:LEFORT LAURENT
摘要:The present invention relates to the synthesis of optically active alcohols by means of enantioselective hydrogenation of ketones in biphasic systems. In particular the present invention relates to the synthesis of an optically active alcohol of general formula (1).

专利号:US-8779122-B2
优先权日:2012-11-08
标 题:Process for the synthesis of (2E)-3-(3,4-dimethoxyphenyl)prop-2-enenitrile, and application in the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid
发明人：CARRANZA MARIA DEL PILAR; GARCIA ARANDA MARIA ISABEL; GONZALEZ JOSÉ LORENZO; SANCHEZ FRÉDÉRIC
权利人:SERVIER LAB
摘要:Process for the synthesis of the compound of formula (I): n nApplication in the synthesis of ivabradine, addition salts thereof with a pharmaceutically acceptable acid and hydrates thereof.