CAS: 10176-71-3; Ladanein
该化合物是一种富罗万类衍生物,其特征为苯丙丙酮核心,具有多种氢氧和甲基氧替代成分,其结构特征,包括二氢氧和甲氧功能组,有助于其作为有机合成和制药研究中间体的潜力.该化合物的多元苯丙基性质可能具有抗氧化特性,而其甲氧基组则会增强稳定性和脂质,使其适合医学化学研究.其定义明确的分子结构允许精确的修改,有利于在生物活性化合物开发中探索结构-活动关系.这一化合物因其功能的多功能性,对药物发现和生物化学研究的应用很有意义.
- 英文名称Ladanein
- 中文名称5,6-二羟基-7,4'-二甲氧基黄酮
- IUPAC名称5,6-dihydroxy-7-methoxy-2-(4-methoxyphenyl)-4H-chromen-4-one
- 其它别名5,6-Dihydroxy-7,4'-Dimethoxyflavone ; 5,6-Dihydroxy-7-Methoxy-2-(4-Methoxyphenyl)Chromen-4-One ; 5,6-Dihydroxy-7-Methoxy-2-(4-Methoxyphenyl)-4H-1-Benzopyran-4-One
- CAS编号10176-71-3
- MFCD编号:MFCD28100661
- 分子式:C17H14O6分子量:314.29
- 产品CID: 35726
- 产品分类天然产物 → 黄酮类化合物
物理性质
上下游产品
3,6-dihydroxy-2,4-dimethoxyacetophenone p-Methoxybenzoic anhydride 6-hydroxy-5,7-dimethoxy-2-(4-methoxyphenyl)-4H-chromen-4-one Acetic acid 5,7-dimethoxy-2-(4-methoxy-phenyl)-4-oxo-4H-chromen-6-yl esterToluene-4-sulfonic acid 6-hydroxy-7-methoxy-2-(4-methoxy-phenyl)-4-oxo-4H-chromen-5-yl ester 18H14O6C18H14O6合成工艺路线路线简述
- 合成目标产物 Scutellarein 4',7- Dimethyl Ether 主要起始原料 6-Hydroxy-5,7-Dimethoxy-2-(4-Methoxyphenyl)-4H-Chromen-4-One
- (文献来源)合成步骤主要原料 6-Hydroxy-5,7-Dimethoxy-2-(4-Methoxyphenyl)-4H-Chromen-4-One
📜2-羟基-4,6-二甲氧基苯乙酮置于dipotassium Peroxodisulfate,硫酸,三溴化硼,溶剂黄146,Sodium Hydroxide,Lithium Hydroxide,Lithium Hexamethyldisilazane体系中,用 四氢呋喃,二氯甲烷,水 用作溶剂,化学反应 177.0H,反应生成5,6-二羟基-7,4'-二甲氧基黄酮
参考文献:Flavone Derivatives And Their Use
标题:Flavone Derivatives And Their Use
摘要:本发明涉及黄酮衍生物及含有一种或多种这些黄酮衍生物的组合物.本发明还涉及用于治疗和/或预防病毒感染的黄酮衍生物或组合物,并涉及一种预防或治疗这些感染的方法.
海关参考信息
- 2905199090-其他饱和一元醇
2905399099-其他二元醇
2905499000-其他多元醇
2905590090-其他无环醇的卤化、磺化等衍生物 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: Ismail NA, Jusoh SA. Molecular Docking and Molecular Dynamics Simulation Studies to Predict Flavonoid Binding on the Surface of DENV2 E Protein. Interdiscip Sci. 2017 Dec;9(4):499-511. doi: 10.1007/s12539-016-0157-8. Epub 2016 Mar 11. doi: 10.1080/03601234.2015.1058103. doi: 10.4137/BBI.S15211. eCollection 2014.
5: Farjam MH, Rustaiyan A, Ezzatzadeh E, Jassbi AR. Labdane-Type Diterpene and Two Flavones from Salvia Sharifii Rech. f. and Esfan. and their Biological Activities. Iran J Pharm Res. 2013 Spring;12(2):395-400.
6: Calland N, Dubuisson J, Rouillé Y, Séron K. Hepatitis C virus and natural compounds: a new antiviral approach? Viruses. 2012 Oct 17;4(10):2197-217. doi: 10.3390/v4102197. Review.
合成参考文献
参考文献:10.1007/978-981-15-5917-4_12
摘要:Dar SA, Bhushan A, Gupta P. Chemical Constituents and Pharmacological Activities of Marrubium vulgare L., an Important Medicinal Herb. 2020. In: Botanical Leads for Drug Discovery.
参考文献:10.1016/s0031-9422(96)00430-x
摘要:Grayer RJ, Bryan SE, Veitch NC, Goldstone FJ, Paton A, Wollenweber E. External flavones in sweet basil, Ocimum basilicum, and related taxa. Phytochemistry. 1996 Nov;43(5):1041–7. doi: 10.1016/s0031-9422(96)00430-x.
参考文献:10.1016/j.arabjc.2011.05.013
摘要:Segueni N, Zellagui A, Moussaoui F, Lahouel M, Rhouati S. Flavonoids from Algerian propolis. Arabian Journal of Chemistry. 2016 Sep;9():S425–8. doi: 10.1016/j.arabjc.2011.05.013.
参考文献:10.1016/0305-1978(91)90088-h
摘要:Tomas-Barberan FA, Gil MI, Marin PD, Tomas-Lorente F. Flavonoids from some Yugoslavian Micromeria species: Chemotaxonomical aspects. Biochemical Systematics and Ecology. 1991 Nov;19(8):697–8. doi: 10.1016/0305-1978(91)90088-h.
参考文献:10.1016/s0031-9422(97)00312-9
摘要:Gökdil G, Topcu G, Sönmez U, Ulubelen A. Terpenoids and flavonoids from Salvia cyanescens. Phytochemistry. 1997 Oct;46(4):799–800. doi: 10.1016/s0031-9422(97)00312-9.
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