CAS: 95847-70-4; 2-(4-(4-(Pyrimidin-2-yl)Piperazin-1-yl)Butyl)Benzo[d]Isothiazol-3(2H)-One 1,1-Dioxide

上下游产品

N-[4-溴丁基]糖精 N-[4-Bromobutyl]Saccharin 103564-59-6
糖精 Saccharin 81-07-2

📜Potassium 4-(1,1-Dioxido-3-Oxobenzo[d]Isothiazol-2(3H)-yl)Butyl Sulfate置于硫酸,水,Potassium Hydrogencarbonate,三乙胺体系中,用 乙酸乙酯,甲苯,乙腈 作为反应溶剂,化学反应 42.0H,反应生成 伊沙匹隆
参考文献:Processes For Making Alkylated Arylpiperazine And Alkylated Arylpiperidine Compounds Including Novel Intermediates
标题:Processes For Making Alkylated Arylpiperazine And Alkylated Arylpiperidine Compounds Including Novel Intermediates
摘要:用于制备通式(I)和(Vii)中所示的烷基化芳基哌嗪和烷基化芳基哌啶化合物的新工艺和中间体,其中,R1和r2分别选择自氢,烷基,取代基或烷基;n=0,1或2;y=nr3R4,Or5或sr5,其中r3和r4分别选择自酰基或磺酰基,R5是芳基或杂芳基,或杂环烷基;ar是芳基,杂芳基或杂环烷基.

专利信息

专利号:US-7576211-B2
优先权日:2004-09-30
标题 :Synthesis of thienopyridinone compounds and related intermediates
发明人：DHANOA DALE S; BECKER OREN; NOIMAN SILVIA; CHEN DONGLI; MARANTZ YAEL; SHACHAM SHARON; HEIFETZ ALEXANDER; INBAL BOAZ; BAR-HAIM SHAY; MOHANTY PRADYUMNA; LOBERA MERCEDES; WU LAURENCE
权利人:EPIX DELAWARE INC
摘要:The invention relates to 5-HT receptor agonists and partial agonists. Novel thienopyridinone compounds represented by Formula I, and synthesis and uses thereof for treating diseases mediated directly or indirectly by 5-HT receptors, are disclosed. Such conditions include Alzheimer's disease, cognition disorders, irritable bowel syndrome, nausea, emesis, vomiting, prokinesia, gastroesophageal reflux disease, nonulcer dyspepsia, depression, anxiety, urinary incontinence, migraine, arrhythmia, atrial fibrillation, ischemic stroke, gastritis, gastric emptying disorders, feeding disorders, gastrointestinal disorders, constipation, erectile dysfunction, and respiratory depression. Methods of preparation and novel intermediates and pharmaceutical salts thereof are also included.

专利号:US-7309799-B2
优先权日:2004-06-01
标 题:Methods for the synthesis of milnacipran and congeners thereof
发明人：BUCHWALD STEPHEN L; SWAGER TIMOTHY M; RARIY ROMAN V
权利人:COLLEGIUM PHARMACEUTICAL INC
摘要:One aspect of the present invention relates to methods for synthesizing milnacipran or congeners thereof. Another aspect of the present invention relates to asymmetric methods for synthesizing enantiomerically enriched milnacipran or congeners thereof. The present invention also relates to methods for synthesizing intermediates useful in the non-asymmetric or asymmetric methods for synthesizing enantiomerically enriched milnacipran or congeners thereof.

专利号:US-2012282255-A1
优先权日:2011-04-07
标题 :Methods and compositions for the treatment of alcoholism and alcohol dependence
发明人：PLUCINSKI GREG
权利人:PLUCINSKI GREG
摘要:The present invention provides for compositions and methods for treating or preventing addictive and compulsive diseases and disorders, particular alcohol-related diseases and disorders, disclosed herein. The GLP activators of the present invention are effective against various alcohol and drug dependency diseases. In accordance with the invention, the present compositions and methods can be used to intercede upstream or downstream in the signal transduction cascade involved in GLP action to treat various alcohol and drug dependency diseases. In one embodiment, the synthesis or release of endogenous GLP can be stimulated. In another embodiment, the endogenous synthesis or release of another molecule active in the cascade downstream from GLP, (e.g., a molecule produced in response to GLP binding to a receptor), can be stimulated. Accordingly, the methods and compositions of the invention are useful for preventing, treating, diagnosing, or monitoring the progression various alcohol and drug dependency diseases disclosed herein.

专利号:US-7585627-B2
优先权日:2004-05-21
标 题 :Polymorphism in tryptophan hydroxylase-2 controls brain serotonin synthesis
发明人：CARON MARC G; ZHANG XIAODONG; BEAULIEU MARTIN; GAINETDINOV RAUL R; SOTNIKOVA TATIANA D; KRISHNAN RANGA R; SCHWARTZ DAVID A; BURCH LAURANELL; WILLIAMS REDFORD B
权利人:UNIV DUKE
摘要:A method of screening a subject for a serotonergic neurotransmission dysregulation disorder comprises detecting the presence or absence of an Tph2 mutation in the subject; and then determining that the subject is at increased risk of a serotonergic neurotransmission dysregulation disorder due to the presence or absence of the Tph2 mutation.

专利号:RU-2726764-C1
优先权日:2019-12-18
标 题:Recombinant plasmid dna aav synh1-2_shrna freud-1, providing synthesis of shphk, suppressing expression of gene coding selective silenser 5-ht1a of receptor freud-1, in brains of mammals

专利号:US-10906888-B2
优先权日:2016-07-14
标 题:Pyrimidine carboxamides as inhibitors of Vanin-1 enzyme
发明人：CASIMIRO-GARCIA AGUSTIN; STROHBACH JOSEPH WALTER; HEPWORTH DAVID; LOVERING FRANK ELDRIDGE; CHOI CHULHO; ALLAIS CHRISTOPHE PHILIPPE; WRIGHT STEPHEN WAYNE
权利人:PFIZER
摘要:Compounds, pharmaceutically acceptable salts thereof, are disclosed wherein the compounds have the structure of (I) as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.