CAS: 89892-21-7; 6-Bromoquinazoline

上下游产品

quinazoline N-(2-chloro-5-(quinazolin-6-yl)pyridin-3-yl)benzenesulfonamide N-(2-chloro-5-(quinazolin-6-yl)pyridin-3-yl)-4-fluorobenzenesulfonamide 4-(quinazolin-6-yl)phenyl α-D-mannopyranoside 6-(2-fluoro-4-methyl-5-((2,2,2-trifluoroethyl)thio)phenyl)quinazoline

📜喹唑啉置于n-溴代丁二酰亚胺(Nbs),硫酸体系中,用 三氟乙酸 作为反应溶剂,化学反应 17.0H,反应生成 6-溴喹唑啉
参考文献:Trifluoromethyl Substituted Benzamides As Kinase Inhibitors
标题:Trifluoromethyl Substituted Benzamides As Kinase Inhibitors
摘要:该发明涉及公式i的三氟甲基取代苯甲酰胺化合物,包括这些化合物的药物,其作为药物或用于制造药物的用途,特别是作为蛋白激酶抑制剂,特别是作为ephrin受体激酶的抑制剂,和/或用于治疗由蛋白激酶活性介导的疾病状态,紊乱或疾病的方法,包括给予这些化合物的治疗方法,特别是治疗和预防治疗的方法,以及化合物的制造方法和用于它们合成的新型中间体和部分步骤.

专利信息

专利号:WO-2023072969-A1
优先权日:2021-10-26
标题 :Imidazolone derivatives as inhibitors of protein kinases in particular dyrk1a, clk1 and/or clk4
发明人：DEAU EMMANUEL; GEORGE PASCAL; MEIJER LAURENT; MIEGE FRÉDÉRIC; ARCHAMBAUD SYLVIE
权利人:PERHA PHARMACEUTICALS
摘要:The present invention relates to a compound of formula (I) wherein A, B, C, D and E are selected from the group consisting of =CH- and -N=, R 2 is selected from a hydrogen atom, a (C 1 -C 4 )alkyl group and a (C 3 -C 6 )cycloalkyl group, R 1 represents a (C 4 -C 6 )alkyl group, a (C 3 -C 8 )cycloalkyl group, a bridged (C 6 -C 10 )cycloalkyl group, a fused phenyl group, a substituted phenyl group, a R'-L- group, wherein L is either a single bond or a (C 1 -C 3 )alkanediyl group, and R' represents, a (C 3 -C 8 )heterocycloalkyl group, or a (C 3 -C 8 )heteroaryl group, or a R'-L- group wherein L is a (C 1 -C 3 )alkanediyl group, and R' is a an optionally substituted phenyl group or any of its pharmaceutically acceptable salt. The present invention further relates to a composition comprising a compound of formula (I) and a process for manufacturing said compound as well as its synthesis intermediates. It also relates to said compound for use as a medicament, in particular in the treatment and/or prevention of cognitive deficits and neuroinflammation associated with Down syndrome, Alzheimer's disease, dementia and/or tauopathies; Parkinson's disease; CDKL5 Deficiency Disorder; Phelan-McDermid syndrome; autism; type 1 and type 2 diabetes; abnormal folate and methionine metabolism; tendinopathy and osteoarthritis; Duchenne muscular dystrophy; several cancers; neuroinflammation, anemia, infections and for regulating body temperature.

专利号:US-2008096883-A1
优先权日:2004-08-11
标题 :Trifluoromethyl substituted benzamides as kinase inhibitors
发明人：CARAVATTI GIORGIO; FURET PASCAL; IMBACH PATRICIA; MARTINY-BARON GEORG; PEREZ LAWRENCE BLAS; SHENG TAO
权利人:CARAVATTI GIORGIO; FURET PASCAL; IMBACH PATRICIA; MARTINY-BARON GEORG; PEREZ LAWRENCE BLAS; SHENG TAO
摘要:The invention relates to trifluoromethyl substituted benzamide compounds of the formula (I), pharmaceuticals comprising these compounds, their use as or for the manufacture of pharmaceuticals, particularly as inhibitors of protein kinases and/or the treatment of a condition, disorder or disease state mediated by a protein kinase activity and/or a proliferative disease, methods of treatment comprising administering the compounds, especially of therapeutic and prophylactic treatment, methods for the manufacture of the compounds and novel intermediates and partial steps for their synthesis.