CAS: 79-37-8; Oxalyl Chloride

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CAS号144-62-7 草酸 | CAS号446-32-2 2-氨基-4-氟苯甲酸 | CAS号75-44-5 光气 | CAS号133349-02-7 perchloro-1,4-d... | CAS号95-92-1 草酸二乙酯 | CAS号98020-90-7 bis(trichlorome... | CAS号127-18-4 四氯乙烯 | CAS号79-01-6 三氯乙烯 | CAS号63938-37-4 1,2-Diethoxy-1,... | CAS号10026-13-8 五氯化磷 | CAS号111944-30-0 bis(3-phenylpro... | CAS号109948-27-8 2-oxo-2-(N-(2-o... | CAS号52351-75-4 6-甲氧基靛红 | CAS号108937-87-7 4-甲氧基-吲哚啉-2,3-二酮 | CAS号10604-20-3 1-(benzylidenea... | CAS号1066-52-0 [chloro(methyl)... | CAS号108807-05-2 4-(4-phenylbuto... | CAS号111478-90-1 7-ETHYLINDOLE-3... | CAS号101349-12-6 5-氟色醇 | CAS号72887-55-9 3-Benzyloxy-5,5...

四氯乙烯置于吡啶,四氧化锇体系中,化学反应生成 草酰氯
参考文献:Herrmann,Wolfgang A.; Eder,Stefan J.,Chemische Berichte,1993,Vol. 126,# 1,P. 31-38
标题:Herrmann,Wolfgang A.; Eder,Stefan J.,Chemische Berichte,1993,Vol. 126,# 1,P. 31-38

专利信息

专利号:US-6013829-A
优先权日:1996-02-05
标 题 :Process for the asymmetric synthesis of S-acyl derivatives of 2-mercaptomethyl -3- phenyl propanoic acid, application to the synthesis of N-(mercaptoacyl) amino acid derivatives
发明人：DANVY DENIS; MONTEIL THIERRY; DUHAMEL PIERRE; DUHAMEL LUCETTE; LECOMTE JEANNE-MARIE; SCHWARTZ JEAN-CHARLES; NOEL-LEFEBVRE NADINE; GROS CLAUDE; PLAQUEVENT JEAN-CHRISTOPHE
权利人:BIOPROJET SOC CIV
摘要:PCT No. PCT/FR97/00218 Sec. 371 Date Nov. 26, 1997 Sec. 102(e) Date Nov. 26, 1997 PCT Filed Feb. 4, 1997 PCT Pub. No. WO97/29086 PCT Pub. Date Aug. 14, 1997Process for the asymmetric synthesis of S-acyl derivatives of 2-mercaptomethyl-3-phenylpropanoic acid of formula (I): characterized in that it comprises the steps consisting in: a) preparing the diol (VI) by reduction of a malonic ester (V) in the presence of a hydride; b) preparing the monoacetates (VII R) or (VII S) respectively; c) subjecting these monoacetates to an oxidation in order to form the acids (IX S) or (IX R); d) saponifying the compounds (IX S) or (IX R) in order to form the hydroxy acids (X S) or (X R); e) thioacylating the hydroxy acids (X S) or (X R) with a mercapto acid R1SH (XI), according to a Mitsunobu-type reaction, in order to lead to the desired acids (I R) (I S) respectively and application to the synthesis of N-(mercaptoacyl)amino acid derivatives (II).

专利号:US-5118853-A
优先权日:1988-10-13
标题:Processes for the synthesis of 3-disubstituted aminoacroleins
发明人：LEE GEORGE T; REPIC OLJAN
权利人:SANDOZ LTD
摘要:Process for the synthesis of compounds of the formula ##STR1## comprising the steps of (i) reacting a compound of the formula ##STR2## with oxalyl chloride or oxalyl bromide to form the corresponding compound of the formula ##STR3## (ii) reacting said compound of the formula ##STR4## with a compound of the formula ##STR5## to form the corresponding compound of the formula ##STR6## (iii) hydrolyzing said compound of the formula ##STR7## to obtain the corresponding compound of the formula ##STR8## the use of the compounds of the formula ##STR9## for the synthesis of the compounds of the formula ##STR10## and the use of the intermediates of Formula VII for the direct synthesis of the compounds of Formula II, n wherein n R 1 is C 1-3 alkyl, phenyl or phenyl substituted by 1 to 3 substituents each of which is independently C 1-3 alkyl, C 1-3 alkoxy, fluoro, chloro, bromo or nitro (maximum of two nitro groups), n R 1b is phenyl or phenyl substituted by 1 to 3 substituents each of which is independently C 1-3 alkyl, C 1-3 alkoxy, fluoro, chloro, bromo or nitro (maximum of two nitro groups), n R 2 is C 1-3 alkyl, n one of R 3 and R 4 is ##STR11## and the other is primary or secondary C 1-6 alkyl not containing an asymmetric carbon atom, C 3-6 cycloalkyl or phenyl-(CH 2 ) m -, n wherein n R 7 is hydrogen, C 1-3 alkyl, n-butyl, i-butyl, t-butyl, C 1-3 alkoxy, n-butoxy, i-butoxy, trifluoromethyl, fluoro, chloro, phenoxy or benzyloxy, n R 8 is hydrogen, C 1-3 alkyl, C 1-3 alkoxy, trifluoromethyl, fluoro, chloro, phenoxy or benzyloxy, n R 9 is hydrogen, C 1-2 alkyl, C 1-2 alkoxy, fluoro or chloro, and n m is 1, 2 or 3, with the provisos that not more than one of R 7 and R 8 is trifluoromethyl, not more than one of R 7 and R 8 is phenoxy, and not more than one of R 7 and R 8 is benzyloxy, n R 5 is hydrogen, C 1-3 alkyl, n-butyl, i-butyl, t-butyl, C 3-6 cycloalkyl, C 1-3 alkoxy, n-butoxy, i-butoxy, trifluoromethyl, fluoro, chloro, phenoxy or benzyloxy, and n R 6 is hydrogen, C 1-3 alkyl, C 1-3 alkoxy, trifluoromethyl, fluoro, chloro, phenoxy, or benzyloxy, with the provisos that not more than one of R 5 and R 6 is trifluoromethyl, not more than one of R 5 and R 6 is phenoxy, and not more than one of R 5 and R 6 is benzyloxy, n R 10 is C 1-6 alkyl, each X is chloro or bromo, and each X.sup.⊖ is chloride or bromide.

专利号:WO-2025215225-A1
优先权日:2024-04-12
标题:Method for the synthesis of 5-methoxy-2-(2h-1,2,3-triazol-2-yl)benzoic acid, a sodium salt of said acid as a synthetic intermediate, and use of the acid or the salt thereof in the preparation of daridorexant and certain intermediates in the synthesis thereof
发明人：AKHATOU ABDESLAM; BALLETTE ROBERTO
权利人:MOEHS IBERICA S L
摘要:The invention relates to a method for the synthesis of 5-methoxy-2-(2H-1,2,3-triazol-2-yl)benzoic acid, to the sodium salt of said acid as a synthetic intermediate, and to the use of the acid or the salt thereof in the preparation of daridorexant and certain intermediates in the synthesis thereof.

专利号:US-8642809-B2
优先权日:2007-09-25
标 题:Methods of synthesis of certain hydroxamic acid compounds
发明人：REISCH HELGE A; LEEMING PETER; RAJE PRASAD S
权利人:REISCH HELGE A; LEEMING PETER; RAJE PRASAD S; TOPOTARGET UK LTD
摘要:The present invention pertains to the general field of chemical synthesis, and more particularly to methods for the synthesis of certain hydroxamic acid compounds, and in particular, (E)-N-hydroxy-3-(3-phenylsulfamoyl-phenyl)-acrylamide, also known as PXD101 and Belinostat®, comprising, for example, the steps of: (SAF) sulfonamide formation; (PUR C ) optional purification; (AAA) alkenyl-acid addition, comprising: either (i): the steps of, in order: (ACAEA) alkenyl-carboxylic acid ester addition; (PUR E ) optional purification; and (CAD) carboxylic acid deprotection; or (ii): the step of: (ACAA) alkenyl-carboxylic acid addition; (PUR F ) optional purification; (HAF) hydroxamic acid formation; and (PUR G ) optional purification.

专利号:US-5523434-A
优先权日:1995-03-15
标 题 :Synthesis of bleach activators
发明人：BURNS MICHAEL E; SIMPSON ANTHONY J
权利人:PROCTER & GAMBLE
摘要:The synthesis of phenol sulfonate esters of alkanoyl amino acids is conducted in the presence of aqueous base to provide bleach activator compounds. Thus, the acid chloride of N-nonanoyl-6-aminocaproic acid is reacted with the sodium salt of p-phenol sulfonate in the presence of water at a pH in the range of about 9 to about 12 to yield the corresponding phenol sulfonate ester. The synthesis of the phenol sulfonate ester of the monononyl amide of adipic acid is also illustrated.

专利号:WO-2024183094-A1
优先权日:2023-03-07
标 题 :Use of ligand catalyst in synthesis of indole alkaloids
发明人：YAN PUCHA; Cheng Houan; ZHOU BO; HUA YUNYU; SUN ZEBIN; FU XINGFENG; LI YUANQIANG
权利人:ZHEJIANG JIUZHOU PHARM CO LTD
摘要:The present invention provides use of a ligand catalyst in the synthesis of indole alkaloids. The ligand catalyst is formula (1). A method for the catalytic synthesis of the indole alkaloids comprises the following steps: sequentially adding reactants, a metal catalyst, a ligand catalyst, an oxidizing agent, and an additive into a reaction container, adding an organic solvent, carrying out the reaction, and carrying out separation and purification to obtain an indole derivative. The chemical reaction formula of the indole derivative is as follows: formula (2), wherein R1 is selected from one of hydrogen, alkyl, alkoxy, and aryl, R2 is selected from one of trifluoromethanesulfonyl, p-toluenesulfonyl, hydrogen, and alkyl, R3 is selected from one of alkyl, alkoxy, aryl, and heteroaryl, and R4 is selected from one of hydrogen, alkyl, alkoxy, aryl, and heteroaryl. The present invention solves the problem of low yield due to C(sp3)–H bonds being difficult to activate, and generates C-H bonds activated by means of the ligand, thereby reducing by-products.