CAS: 78603-93-7; (R)-2-Amino-1,1-Diphenylpropan-1-Ol

上下游产品

D-alanine methyl ester hydr°Chloride 2-amino-1,1-diphenyl-1-propanol phenylmagnesium bromide bromobenzene naphthalene-1-sulfonic acid ((R)-2-hydroxy-1-methyl-2,2-diphenyl-ethyl)-amide

📜Alkaline Earth Salt Of/the/ Methylsulfuric Acid置于camphor-10-Sulfonic Acid体系中,化学反应生成 (R)-(+)-2-氨基-1,1-二苯基-1-丙醇
参考文献:Molecular Rearrangements. Xi. The Deamination Of 1,1-Diphenyl-2-Amino-1-Propanol1
标题:Molecular Rearrangements. Xi. The Deamination Of 1,1-Diphenyl-2-Amino-1-Propanol1
摘要:
DOI:10.1021/ja01580A015

专利信息

专利号:US-2013253061-A1
优先权日:2012-03-20
标 题:Method of droxidopa synthesis
发明人：PIMPLASKAR HARISH K; KADAM SHASHIKANT VITHAL; MALLESH VOORADI; KAWALE PRAMOD MANGALDAS
权利人:CHELSEA THERAPEUTICS INC
摘要:The present application relates to a novel method of preparing L-threo-dihydroxyphenylserine (droxidopa). Specifically, the application is directed to a method of preparing droxidopa via a deprotection step that is an alternative to deprotection steps that have been previously disclosed. The new deprotection strategy is advantageous in that it avoids the need to use hydrogenolysis or hydrazine.

专利号:WO-2013142093-A1
优先权日:2012-03-20
标题 :Method for the synthesis of droxidopa

专利号:US-4480109-A
优先权日:1982-01-14
标 题:Process for producing threo-3-(3,4-dihydroxyphenyl)serine
发明人：OHASHI NAOHITO; NAGATA SHOJI; ISHIZUMI KIKUO
权利人:SUMITOMO CHEMICAL CO
摘要:A process for producing an optically active threo-3-(3,4-dihydroxyphenyl)serine represented by the formula ##STR1## which is useful as a remedy for peripheral orthostatic hypotension or as an antidepressant, which process comprises treating threo-3-(3,4-methylenedioxyphenyl)serine or an N-carbobenzoxy derivative thereof represented by the formula ##STR2## wherein A represents a hydrogen atom or a carbobenzoxy group, with a Lewis acid to form threo-3-(3,4-dihydroxyphenyl)serine or an N-carbobenzoxy derivative thereof represented by the formula ##STR3## wherein A is as defined above, and, if A is a carbobenzoxy group, catalytically reducing the resulting compound of formula [2]; a racemic or optically active threo-N-carbobenzoxy-3-(3,4-methylenedioxyphenyl)serine represented by the formula ##STR4## which is a novel compound useful as an intermediate in the above synthesis; and a process for producing said novel compound.