CAS: 6964-20-1; Thiadenol

该化合物是一种化学化合物,属于被称为苯酚的有机化合物类别,其特点是其结构,通常包括一个附于芳香烃的氢氧基化合物(-OH),众所周知,由于其生物活动,它有可能在各个领域,包括制药和农用化学物质,应用到包括制药和农用化学物质在内的各个领域,该化合物可能具有抗氧化剂活动等特性,有助于保护细胞免受氧化性压力.此外,Tiadenol可能会对医药化学产生影响,成为开发新治疗剂的主导化合物,其溶性,稳定性和再活性可能因具体情况和其他功能组的存在而不同.与许多化学物质一样,安全和处理预防措施至关重要,因为如果管理不当,Tiadenol可能会带来风险.总的来说,Tiadenol是在各个科学领域进行进一步研究和应用的有趣化合物.

结构式图片

物理性质

MSDS等安全信息

    上下游产品

    1,10-dibromodecane 2-hydroxyethanethiol 1,10-decadiene

    合成工艺路线路线简述

      📜1,9-癸二烯,2-巯基乙醇置于过氧化叔戊酸叔丁酯体系中,用 乙腈 作为反应溶剂,化学反应 2.0H,以96%的收率获得产物2,2'-(十亚甲基二硫代)二乙醇
      参考文献:Ameduri,Bruno; Berrada,Khalid; Boutevin,Bernard,Phosphorus,Sulfur And Silicon And The Related Elements,1993,Vol. 83,# 1-4,P. 39-48
      标题:Ameduri,Bruno; Berrada,Khalid; Boutevin,Bernard,Phosphorus,Sulfur And Silicon And The Related Elements,1993,Vol. 83,# 1-4,P. 39-48

      海关参考信息

      专利信息


      专利号:US-10925977-B2
      优先权日:2006-10-05
      标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
      发明人：YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S
      权利人:YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S; CEIL POINT LLC; UNIV TEXAS
      摘要:Novel methods of synthesis of chelator-targeting ligand conjugates, compositions comprising such conjugates, and therapeutic and diagnostic applications of such conjugates are disclosed. The compositions include chelator-targeting ligand conjugates optionally chelated to one or more metal ions. Methods of synthesizing these compositions in high purity are also presented. Also disclosed are methods of imaging, treating and diagnosing disease in a subject using these novel compositions, such as methods of imaging a tumor within a subject and methods of diagnosing myocardial ischemia.

      专利号:KR-101513003-B1
      优先权日:2006-10-05
      标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy compositions and applications

      专利号:US-10814013-B2
      优先权日:2006-10-05
      标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications

      专利号:AU-2007308022-A2
      优先权日:2006-10-05
      标题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications

      专利号:AU-2007308022-A1
      优先权日:2006-10-05
      标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications

      专利号:US-2008107598-A1
      优先权日:2006-10-05
      标 题:Efficient Synthesis of Chelators for Nuclear Imaging and Radiotherapy: Compositions and Applications

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      ✅ COA系统入驻 | 共享模式

      主要参考文献


      1: Maffei Facino R, Carini M, Tofanetti O. Carboxylic metabolites of tiadenol as "proximate" inducers of hepatic peroxisomal beta-oxidation activity. Pharmacol Res Commun. 1988 Apr;20(4):265-76. French. Italian. Italian. Italian.
      16: Modugno P. [Preventive use of tiadenol in pulmonary fat embolism in rabbits with multiple experimental fractures]. Arch Sci Med (Torino). 1982 Oct-Dec;139(4):419-24. Italian. French.

      合成参考文献


      参考文献:10.1021/tx900326k
      摘要:Fourches D, Barnes JC, Day NC, Bradley P, Reed JZ, Tropsha A. Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chem Res Toxicol. 2010 Jan;23(1):171–83.
      参考文献:10.1016/0300-483x(92)90062-j
      摘要:Kawashima Y, Kozuka H. Cytosolic long-chain acyl-CoA hydrolase, a suitable parameter to measure hepatic response to peroxisome proliferators. Toxicology. 1992;71(1-2):151–60. doi: 10.1016/0300-483x(92)90062-j.
      参考文献:10.1007/bf02536469
      摘要:Asiedu D, Skorve J, Demoz A, Willumsen N, Berge RK. Relationship between translocation of long-chain acyl-CoA hydrolase, phosphatidate phosphohydrolase and CTP:phosphocholine cytidylyltransferase and the synthesis of triglycerides and phosphatidylcholine in rat liver. Lipids. 1992 Apr;27(4):241–7. doi: 10.1007/bf02536469.
      参考文献:10.1007/bf02534363
      摘要:Berge RK, Thomassen MS. Effects of high fat diets on the activity of palmitoyl-CoA hydrolase in rat liver. Lipids. 1985 Jan;20(1):49–52. doi: 10.1007/bf02534363.
      参考文献:10.1002/ijc.2910360413
      摘要:Berge RK, Lillehaug JR. Tiadenol-mediated induction of peroxisomal enzymes in cultured C3H/10T1/2CL8 cells and in chemically transformed C3H/10T1/2 MCA16 cells. Int J Cancer. 1985 Oct 15;36(4):489–94. doi: 10.1002/ijc.2910360413.
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