CAS: 60853-81-8; 2-(Dimethylamino)Acetyl Chloride Hydrochloride

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CAS号2491-06-7 N,N-二甲基甘氨酸盐酸盐 | CAS号1118-68-9 N,N-二甲基甘氨酸

📜N,N-二甲基甘氨酸置于草酰氯,N,N-二甲基甲酰胺体系中,用 二氯甲烷 作为反应溶剂,化学反应生成 二甲基氨基氯化氢
参考文献:开发了一系列作为g-四链体配体的双三唑†
标题:开发了一系列作为g-四链体配体的双三唑†
摘要:端粒酶(一种保护染色体末端的特殊复合物)的维护是由端粒酶复合物提供的,端粒酶是80%以上的癌细胞激活但在大多数正常细胞中却不存在的关键因素.靶向端粒维持机制可能会阻止多种癌症类型的肿瘤生长.染色体的端粒末端由富含鸟嘌呤的dna的非编码重复序列组成.这些富含g的末端可以折叠成称为g-四链体的结构.通过称为g4配体的小结合分子稳定g-四链体可以阻止端粒酶维持癌细胞中端粒的完整性.g-四链体也可以存在于基因组的其他部分,尤其是在癌基因的启动子序列中,并且也是有趣的药物靶标.这里,我们描述了一系列新的新型双三唑的开发,这些双三唑旨在稳定地将g-四链体结构作为g4配体来稳定.fret分析显示两种化合物是中等有效的g4结合剂,对由hsp90A启动子序列形成的四链体具有特定的亲和力,并且对g-四链体dna具有非常好的选择性与双链dna.但是,Cd光谱法未能提供有关由于其与配体之一相互作用而导致的人类端粒g
DOI:10.1039/c7Ra07257K

专利信息

专利号:WO-2012047907-A9
优先权日:2010-10-04
标题 :Synthesis of c5-substituted tetracyclines, uses thereof, and intermediates thereto
发明人：MYERS ANDREW G; WRIGHT PETER M; HECKER EVAN
权利人:HARVARD COLLEGE; MYERS ANDREW G; WRIGHT PETER M; HECKER EVAN
摘要:The tetracycline class of antibiotics has played a major role in the treatment of infectious diseases for the past 50 years. However, the increased use of the tetracyclines in human and veterinary medicine has led to resistance among many organisms previously susceptible to tetracycline antibiotics. The recent development of a modular synthesis of tetracycline analogs through a chiral enone intermediate has allowed for the efficient synthesis of novel tetracycline analogs never prepared before. The present invention provides more efficient routes for preparing the enone intermediate and allows for a wide variety of substituents at position 5 of the tetracycline ring system.

专利号:US-9688644-B2
优先权日:2009-04-30
标 题 :Synthesis of Tetracyclines and intermediates thereto
发明人：MYERS ANDREW G; KUMMER DAVID A; LI DERUN; HECKER EVAN; DION AMELIE; WRIGHT PETER M
权利人:HARVARD COLLEGE
摘要:The tetracycline class of antibiotics has played a major role in the treatment of infectious diseases for the past 50 years. However, the increased use of the tetracyclines in human and veterinary medicine has led to resistance among many organisms previously susceptible to tetracycline antibiotics. The recent development of a modular synthesis of tetracycline analogs through a chiral enone intermediate has allowed for the efficient synthesis of novel tetracycline analogs never prepared before. The present invention provides more efficient routes for preparing the enone intermediate and allows for substituents at positions 4a, 5, 5a, and 12a of the tetracycline ring system.

专利号:US-2018312463-A1
优先权日:2015-10-22
标题:Synthesis of Cyclohexane Carboxamide Derivatives Useful as Sensates in Consumer Products
发明人：YELM KENNETH EDWARD; WOS JOHN AUGUST; BUNKE GREGORY MARK; FREDERICK HEATH; HAUGHT JOHN CHRISTIAN; HOKE STEVEN HAMILTON; SREEKRISHNA KOTI TATACHAR; LIN YAKANG
权利人:PROCTER & GAMBLE
摘要:Synthesis methods to produce a series of carboxamides built off of an (S)-2-amino acid backbone or an (R)-2-amino acid backbone, depending upon the desired diastereomer of the end product.

专利号:US-6710185-B2
优先权日:2000-09-20
标 题 :Process for the preparation of cell proliferation inhibitors
发明人：GUPTA ASHOK K; KING STEVEN A; LEE ELAINE C; MORTON HOWARD E; PLATA DANIEL J; PU YU-MING; SHARMA PADAM N
权利人:ABBOTT LAB
摘要:The instant invention discloses a process for the synthesis of substituted indole cell proliferation inhibitors.

专利号:US-2010047841-A1
优先权日:2007-02-27
标 题 :Synthesis of desacetoxytubulysin h and analogs thereof
发明人：WIPF PETER; WANG ZHIYONG
权利人:UNIV PITTSBURGH
摘要:Compounds of formula I, XVI and XXI possess potent cell growth inhibitory activity. These compounds are described have therapeutic utility, particularly in the treatment of cancer as well as conditions and disorders related to uncontrolled cell growth: n n n n n n n n n n wherein the variables R 1 , R 2 , R 3 , R 4 , R 5 , X, Y and Z are described herein.

专利号:WO-2010126607-A2
优先权日:2009-04-30
标 题:Synthesis of tetracyclines and intermediates thereto