CAS: 58536-71-3; 1H-Benzo[d]Imidazole-2-Sulfinic Acid

📜1H-苯并咪唑-2-硫醇置于sodium Molybdate,双氧水体系中,用 乙醇 作为反应溶剂,以42%的收率获得产物1H-苯并咪唑-2-亚磺酸
参考文献:Biological Properties Of Amidinium Sulfinic And Sulfonic Acid Derivatives: Inhibition Of Glycolytic Enzymes Of Trypanosoma Brucei And Protective Effect On Cell Growth
标题:Biological Properties Of Amidinium Sulfinic And Sulfonic Acid Derivatives: Inhibition Of Glycolytic Enzymes Of Trypanosoma Brucei And Protective Effect On Cell Growth
摘要:The Activity Of The Title Compounds Has Been Investigated On Two Biological Targets: Cultures Of Trypanosome And Glycolytic Enzymes Inhibition Of The Parasite,And On Retinal Epithelium Cells. In Both Cases,These Compounds Exhibit A Significant Activity,In Some Cases More Selective Than This For The Drug Suramin,With A Lower Toxicity. The Effect Of These Compounds,Which Exist As Neutral And Zwitterionic Forms In The Case Of Sulfinic,Only As Zwitterionic In The Case Of Sulfonic Derivatives Can Be Understood Via Their Action On Clusters Of Positive Charges Which Are Present At The Surface Of The Proteins Involved In The Processes: Glycolytic Enzymes Of The Trypanosome In The First Part,Basic Fibroblast Growth Factor In The Second.
DOI:10.1016/0223-5234(92)90114-G