CAS: 4205-23-6; (2R,3R,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal

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📜海藻糖置于trehalase 1 From Saccharomyces Cerevisiae体系中,用 甘油 作为反应溶剂,化学反应生成 D-古洛糖
参考文献:酵母中性海藻糖酶nth1的14-3-3蛋白依赖性激活的分子基础
标题:酵母中性海藻糖酶nth1的14-3-3蛋白依赖性激活的分子基础
摘要:14-3-3蛋白是在所有真核细胞中普遍表达的高度保守的支架蛋白家族,可与数百种伴侣蛋白相互作用并调节其功能.酵母中性海藻糖酶(nth)是负责将海藻糖水解为葡萄糖的酶,与其他生物的海藻糖酶相比,具有独特的结构和调控作用,涉及多个位点的磷酸化,然后与14-3-3蛋白结合.在这里,我们报告了酵母nth1的晶体结构及其与bmh1(酵母14-3-3的同工型)的复合物,再加上突变和荧光研究,表明nth1与14-3-3的结合通过使nth1激活而触发nth1的活性. Nth1的催化结构域和钙结合结构域相对于彼此的正确3D构型,因此稳定了催化所需的活性位点的柔性部分.提出的bmh1:Nth1复合体的结构突出了14-3-3调节多结构域结合伴侣结构并充当变构效应子的能力.此外,Bmh1:Nth1复杂结构与14-3-3:5-羟色胺的结构比较n-乙酰基转移酶和14-3-3:热激蛋白β-6复合物在结合的伴侣蛋白的3D
DOI:10.1073/pnas.1714491114

专利信息

专利号:US-2022395800-A1
优先权日:2019-11-04
标题:Device for automated synthesis of oligo- and polysaccharides
发明人：SEEBERGER PETER H; DANGLAD FLORES JOSE; LE MAI HOANG KIM; PARDO VARGAS ALONSO; SLETTEN ERIC; SALWICZEK MARIO
权利人:MAX PLANCK GESELLSCHAT ZU RFERDERUNG DER WSS E V; GlycoUniverse GmbH & Co KG&A
摘要:The present invention generally relates to automated synthesis technology, and more particularly, to a device and method for automated synthesis of oligo- and polysaccharides on a solid support. In particular the present invention relates to a device for automated synthesis of oligo- and polysaccharides on a solid support comprising a reaction vessel, a reagent storing component, a reagent delivery system, a cooling device for cooling reaction vessel, and a pre-cooling device for pre-cooling the reagents to be supplied.

专利号:US-7344863-B2
优先权日:1998-03-13
标题:Methods for producing polypeptides through enhanced synthesis of encoding nucleic acid molecules
发明人：LI WU-BO; JESSEE JOEL A; SCHUSTER DAVID; XIA JIULIN; GEBEYEHU GULILAT
权利人:INVITROGEN CORP
摘要:The present invention is directed to compositions and methods for enhancing synthesis of nucleic acid molecules, particularly GC-rich nucleic acid molecules. Specifically, the invention provides compositions comprising one or more nitrogen-containing organic compounds having a formula selected from the group consisting of formula I and formula II (or salts or derivatives thereof), preferably 4-methylmorpholine N-oxide or betaine (carboxymethyltrimethylammonium), and further comprising one or more compounds selected from the group consisting of proline and an N-alkylimidazole compound, and more preferably proline, 1-methylimidazole or 4-methylimidazole. The invention further relates to methods for enhanced, high-fidelity synthesis of nucleic acid molecules, including via amplification (particularly PCR), reverse transcription, and sequencing methods. The invention also relates to nucleic acid molecules synthesized by these methods, to fragments or derivatives thereof, and to vectors and host cells comprising such nucleic acid molecules, fragments, or derivatives. The invention also relates to kits for synthesizing, amplifying, reverse transcribing or sequencing nucleic acid molecules comprising one or more of the compositions of the invention.

专利号:US-7429658-B2
优先权日:2003-09-11
标题 :Synthesis of protected pyrrolobenzodiazepines
发明人：HOWARD PHILIP; MASTERSON LUKE
权利人:SPIROGEN LTD
摘要:A method of synthesis of a N-10 protected PBD compound of formula (I): n nvia an intermediate of formula (II) or formula (V):

专利号:US-10973847-B2
优先权日:2017-06-30
标题 :Core-to-surface polymerization for the synthesis of star polymers and uses thereof
发明人：JOHNSON JEREMIAH A; GOLDER MATTHEW R
权利人:MASSACHUSETTS INST TECHNOLOGY
摘要:Disclosed are methods, compositions, reagents, systems, and kits to prepare star polymers, as well as compositions and uses thereof. Various embodiments show that synthesis of these polymers contain low metal concentration to provide polymers for diverse biomedical applications including in vivo applications.

专利号:US-7557099-B2
优先权日:2004-03-01
标题 :Pyrrolobenzodiazepines as key intermediates in the synthesis of dimeric cytotoxic pyrrolobenzodiazepines
发明人：HOWARD PHILIP WILSON; KANG GYOUNG-DONG
权利人:SPIROGEN LTD
摘要:Compounds and a method of synthesis of compounds of formula (Ia) or (Ib): and salts, solvates, and chemically protected forms thereof, wherein the dotted lines indicate the optional presence of a double bond between C1 and C2 or C2 and C3; R 2 and R 3 are independently selected from —H, â•?O, â•?CH 2 , —CN, —R, OR, halo, â•?CH—R, O—SO 2 —R, CO 2 R and COR; R 10 is a carbamate-based nitrogen protecting group; and R 11 is an oxygen protecting group.

专利号:US-8183355-B2
优先权日:2006-04-28
标题 :Method for the synthesis of oligonucleotide derivatives
发明人：MORVAN FRANCOIS; MEYER ALBERT; VASSEUR JEAN-JACQUES; VIDAL SEBASTIEN; CLOAREC JEAN-PIERRE; CHEVOLOT YANN; SOUTEYRAND ELIANE
权利人:MORVAN FRANCOIS; MEYER ALBERT; VASSEUR JEAN-JACQUES; VIDAL SEBASTIEN; CLOAREC JEAN-PIERRE; CHEVOLOT YANN; SOUTEYRAND ELIANE; CENTRE NAT RECH SCIENT
摘要:Method for the synthesis of nucleotide derivatives wherein molecules of interest are grafted on the oligonucleotide with the help of a “click chemistryâ€? reaction between an azide function on the molecule of interest and an alkyne function on the oligonucleotide, or between an alkyne function on the molecule of interest and an azide function on the oligonucleotide. n Intermediate molecules, notably alkyne functionalized oligonucleotides, grafted oligonucleotides, azide functionalized oligonucleotides, oligonucleotide micro arrays containing them and the use of those grafted oligonucleotides for biological investigation and for cell targeting.