CAS: 41001-90-5; Hesperetin

该化合物是主要在柑橘水果中发现的花草化合物,以其作为丙酰胺生物活性代谢物的作用而著称,它具有显著的抗氧化剂,抗炎和潜在的化学预防特性,使它成为药物和营养素研究感兴趣的对象.从结构上看,乙型六氯环己烷在B环上具有4'mthoxy组特征,增强了其稳定性和生物活动.它能够调节细胞信号路径,如NF-B和MAPK,强调了其治疗潜力.由于高纯度和标准化的配方, hesperetin适合于药物开发,功能食品和化妆品配方的应用.它的低毒性特征进一步支持其在生物医学研究中的应用.

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MSDS等安全信息

上下游产品

hesperidin G-α-D-glucopyranosyl hesperidin4G-α-D-glucopyranosyl hesperidin (S)-2,3-dihydro-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4-benzopyrone methanol5-hydroxy-3′4′7-trimethoxy flavanone S)-5,7-diacetoxy-2-(3-acetoxy-4-methoxy-phenyl)-chroman-4-one(S)-5,7-diacetoxy-2-(3-acetoxy-4-methoxy-phenyl)-chroman-4-one (-)-hesperetin oxime Hesperetin 7-O-sulfate

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    专利信息


    专利号:WO-2025081225-A1
    优先权日:2023-10-17
    标 题 :Synthesis of polyphenols
    发明人:TURLAND CADE LACHLAN; GROLMAN DAVID; BEHRENDORFF JAMES BRUCE YARNTON HAYCOCK; MORADI SHAYLI VARASTEH; THOMSON RAINE ELIZABETH STURT
    权利人:Delica Therapeutics Pty Ltd
    摘要:The present disclosure relates to polyphenols, including flavonoids, flavones and cannflavins, and methods of synthesising polyphenols. The present disclosure provides methods, enzymes and compositions that may be useful in the synthesis of polyphenols.

    专利号:US-9149659-B2
    优先权日:2012-11-14
    标题 :Cosmetic composition for increasing hyaluronic acid synthesis in skin and its use for repairing wrinkles
    发明人:PUJOS MURIEL; BERNINI DOROTHEE; ROBERT CECILE; DOUCET OLIVIER
    权利人:COTY GERMANY GMBH
    摘要:The present invention relates to a skin composition which has an excellent effect on smoothing or repairing wrinkles. The composition comprises Palmitoyl Tripeptide-38 (Palmitoyl-Lysyl-Dioxymethionyl-Lysine) and Piper nigrum (Pepper) seed Extract which combination has been found to result in a synergistic effect on hyaluronan synthase 1 (HAS1) mRNA expression in human fibroblasts. The hyaluronan synthase is responsible for the synthesis of hyaluronan (hyaluronic acid) in skin. Hyaluronic acid is a constituent of the extracellular matrix of the skin and responsible for space filling, tissue repair and retention of moisture.

    专利号:US-2002165207-A1
    优先权日:2001-05-02
    标题 :Compositions and methods for the treatment of diabetic neuropathy
    发明人:ROSENBLOOM RICHARD
    摘要:Compositions and a method for the treatment of diabetic neuropathy is disclosed. The compositions comprise a mixture of a compound that promotes synthesis of nerve growth factor, an aldose reductase inhibitor and an antioxidant, optionally formulated in a pharmaceutically acceptable carrier. This combination of active agents provides significant, effective relief of the symptoms of diabetic neuropathy, as well as at least partial recovery of lost neurological function in some cases. In addition, the compositions of the present invention, when used in effective amounts to treat diabetic neuropathy, do not exhibit the severe side effects of many prior art compositions proposed for treatment of this ailment. n In a second aspect, a method for the administration of a composition in accordance with the present invention for the treatment of diabetic neuropathy is disclosed. In the method, an effective amount of the composition of the invention is administered on a regular basis over a period of time sufficient to provide the beneficial effects of relief from the symptoms of diabetic neuropathy, as well as at least some recovery of the damaged nerve tissues.

    专利号:US-2024026314-A1
    优先权日:2020-11-25
    标题 :Polypeptides for use in the synthesis of bioactive phenolic compounds
    发明人:ROTHSTEIN STEVEN; AKHTAR TARIQ; CASARETTO JOSE; PERRIN COLBY; VAN GELDER KRISTEN
    权利人:ROTHSTEIN STEVEN; AKHTAR TARIQ; CASARETTO JOSE; PERRIN COLBY; VAN GELDER KRISTEN
    摘要:Described herein is a polypeptide encoding a prenyltransferase for prenylating a polyphenol and a polypeptide encoding an O-methyltransferase for methylating a polyphenol. For example, the polypeptide comprises or consists of the sequence of SEQ ID NO: 1, 2, 3, 4, 5, and/or 6, and/or a polypeptide listed in Table 1, and/or SEQ ID NO: 7-30, or a variant thereof having at least 80% sequence identity to SEQ ID NO: 1, 2, 3, 4, 5, and/or 6, and/or the polypeptide listed in Table 1, and/or SEQ ID NO: 7-30, or a fragment of the polypeptide or the variant thereof.

    专利号:US-7914823-B2
    优先权日:2000-12-21
    标题 :Method and composition for the topical treatment of diabetic neuropathy
    发明人:ROSENBLOOM RICHARD ALLEN
    权利人:PROPHASE LABS INC
    摘要:A method and composition for the treatment of diabetic neuropathy is disclosed. The composition comprises a cold compounded mixture of a compound that promotes synthesis of nerve growth factor, an aldose reductase inhibitor and an antioxidant formulated in a pharmaceutically acceptable carrier. It has been found that this combination of active agents provides significant, effective relief of the symptoms of diabetic neuropathy, as well as at least partial recovery of lost neurological function in some cases. In view of the consensus in the art that effective combinations of various active agents have not been demonstrated to be effective for the treatment of diabetic neuropathy, the present invention provides a surprising and unexpected effect. In addition, the topical compositions of the present invention, when used in effective amounts to treat diabetic neuropathy, do not exhibit the severe side effects of many prior art compositions proposed for treatment of this ailment. n In a second aspect, a method for the topical administration of a composition in accordance with the present invention for the treatment of diabetic neuropathy is disclosed. In the method, an effective amount of the composition of the invention is topically administered to the areas of the body that have been adversely affected by the diabetic neuropathy on a regular basis over a period of time sufficient to provide the beneficial effects of relief from the symptoms and at least some recovery of the damaged nerve tissues.

    专利号:EP-1351679-B1
    优先权日:2000-12-21
    标题 :Method and composition for the treatment of diabetic neuropathy
    发明人:ROSENBLOOM RICHARD A
    权利人:THE QUIGLEY CORP
    摘要:Compositions and a method for the treatment of diabetic neuropathy are disclosed. The compositions comprise a mixture of a compound that promotes synthesis of nerve growth factor, an aldose reductase inhibitor and an antioxidant, optionally formulated in a pharmaceutically acceptable carrier. This combination of active agents provides significant, effective relief of the symptoms of diabetic neuropathy, as well as at least partial recovery of lost neurological function in some cases. In addition, the compositions of the present invention, when used in effective amounts to treat diabetic neuropathy, do not exhibit the severe side effects of many prior art compositions proposed for treatment of this ailment. In a second aspect, a method for the administration of a composition in accordance with the present invention for the treatment of diabetic neuropathy is disclosed. In the method, an effective amount of the composition of the invention is administered over a period of time sufficient to provide the beneficial effects of relief from the symptoms of diabetic neuropathy, as well as at least some recovery of the damaged nerve tissues.

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    合成参考文献


    参考文献:10.1186/1475-2891-10-73
    摘要:Bojić M, Debeljak Ž, Tomičić M, Medić-Šarić M, Tomić S. Evaluation of antiaggregatory activity of flavonoid aglycone series. Nutrition Journal. 2011 Jul 11;10(1):73. doi: 10.1186/1475-2891-10-73.
    参考文献:10.2147/dmso.s18435
    摘要:Bhathena J, Kulamarva A, Martoni C, Urbanska AM, Malhotra M, Paul A, Prakash S. Diet-induced metabolic hamster model of nonalcoholic fatty liver disease. Diabetes Metab Syndr Obes. 2011;4():195–203.
    参考文献:10.1186/1471-230x-11-81
    摘要:Wu H, Jing Z, Tang X, Wang X, Zhang S, Yu Y, Wang Z, Cao H, Huang L, Yu Y, Wang Y. To compare the efficacy of two kinds of Zhizhu pills in the treatment of functional dyspepsia of spleen-deficiency and qi-stagnation syndrome: a randomized group sequential comparative trial. BMC Gastroenterol. 2011 Jul 15;11():81.
    参考文献:10.1021/np50001a002
    摘要:Edwards JM, Raffauf RF, Le Quesne PW. Antineoplastic activity and cytotoxicity of flavones, isoflavones, and flavanones. J Nat Prod. 1979 Jan;42(1):85–91. doi: 10.1021/np50001a002.
    参考文献:10.1155/2011/485402
    摘要:Kim SH, Kim BK, Lee YC. Antiasthmatic effects of hesperidin, a potential Th2 cytokine antagonist, in a mouse model of allergic asthma. Mediators Inflamm. 2011;2011():485402.
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