15803-02-8 = 3994-50-1 + 89607-11-4 + 32683-45-7 反应条件:1.1 Reagents: Sulfuric Acid,Nitric Acid 标题:Nitration Of 4-Halo-1-Methylpyrazoles In Sulfuric Acid 作者:Perevalov,V. P.; Manaev,Yu. A.; Baryshnenkova,L. I.; Kanep,E. E.; Andreeva,M. A.; Et Al 参考文献:Khimiya Geterotsiklicheskikh Soedinenii 日期:1987 卷标:(10) 页码:1350-2]
104599-36-2 + 2075-46-9 + 784193-37-9 = 3994-50-1 + 89607-15-8 + 155600-99-0 + 89607-13-6 反应条件:1.1 Reagents: Potassium Carbonate Solvents: Acetonitrile; 24 H,Reflux; Cooled1.2 Reagents: Ammonia Solvents: Water; 20 Min 标题:Effect Of "Anomalous" Electrochemical Halogenation Of Pyrazoles And Its Reasons 作者:Lyalin,B. V.; Petrosyan,V. A. 参考文献:Russian Chemical Bulletin 日期:2012 卷标:61(1) 页码:209-210
1-甲基-4-碘-吡唑置于硝酸体系中,用 四氢呋喃 用作溶剂,化学反应 2.5H,以86%的收率获得1-甲基-4-硝基吡唑 参考文献:Silica-sulfuric Acid Catalyzed Nitrodeiodination Of Iodopyrazoles 标题:Silica-sulfuric Acid Catalyzed Nitrodeiodination Of Iodopyrazoles 摘要:We Report Here The Synthesis Of Nitropyrazoles In Good To Excellent Yields From Iodopyrazoles Over Silica-Sulfuric Acid Catalyst For The First Time. The Present Procedure Require Less Acid,Offers A Simplified Workup Procedure,And May Be Applied For The Nitration Of A Wide Variety Of Iodoazoles In Drug And Pharmaceutical Industries. Doi:10.1080/00397911.2011.584261
专利号:US-12037636-B2 优先权日:2018-07-19 标题 :Polynucleotide synthesis method, kit and system 发明人:MILTON JOHN; NAYYAR SOBIA; RIEDL JAN; OGAKI RYOSUKE 权利人:OXFORD NANOPORE TECH PLC 摘要:The invention relates to new methods for synthesising polynucleotide molecules according to a predefined nucleotide sequence. The invention also relates to methods for the assembly of synthetic polynucleotides following synthesis, as well as systems and kits for performing the synthesis and/or assembly methods.
专利号:US-2007276139-A1 优先权日:2004-02-10 标题:Substituted Pixyl Protecting Groups for Oligonucleotide Synthesis 发明人:SONG QUANLAI; KHAMMUNGKHUNE SAK; ROSS BRUCE S; GRIFFEY RICHARD H 权利人:SONG QUANLAI; KHAMMUNGKHUNE SAK; ROSS BRUCE S; GRIFFEY RICHARD H 摘要:The present invention describes an improved hydroxyl protecting group of formula (1), wherein R 2 and R 7 are specified substituents and Q is O, S, NR 10 or N(Câ•?O)R 10 .
专利号:US-2007179100-A1 优先权日:2003-04-09 标 题:Protected monomers 发明人:MANOHARAN MUTHIAH 权利人:MANOHARAN MUTHIAH 摘要:This invention relates to protected monomers for the synthesis of iRNA agents.
专利号:CN-118619882-A 优先权日:2024-04-23 标题 :Synthesis method of 1-methyl-3, 4, 5-trinitropyrazole MTNP