CAS: 32690-93-0; 2,4,4',5-Tetrachloro-1,1'-Biphenyl
该化合物是多氯联苯(PCB)家族的成员,该家族由不同程度氯化的合成有机化学品组成,以其联苯结构为特征,多氯联苯74含有联苯骨的多氯原子,影响其物理和化学特性,该化合物一般无色于轻黄色固体或粘度液体,取决于其具体的配方和温度;多氯联苯74等多氯联苯因其化学稳定性,疏水性和降解抗药性而闻名,这助长了多氯联苯在环境中的持久性;它们也是亲脂性化学品,导致活生物体中的生物累积;多氯联苯74已用于各种工业用途,包括电气设备和热传导液,但由于其毒性影响,包括潜在的致癌性和内分泌干扰,许多国家已严重限制或禁止使用多氯联苯.
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- 产品信息参考
;;;; - InChIKey: TULCXSBAPHCWCF-UHFFFAOYSA-N
- 1S/C12H6Cl4/c13-8-3-1-7(2-4-8)9-5-11(15)12(16)6-10(9)14/h1-6H
- 计算化学: 氢键受体数*氢键供体数*可旋转键数1.0
物理性质
MSDS等安全信息
- GHS符号GHS07
- 警示词Warning
- 危险描述H302-H315-H319-H335
- 防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
- 安全声明The mechanism of action varies with the specific PCB. Dioxin-like PCBs bind to the aryl hydrocarbon receptor, which disrupts cell function by altering the transcription of genes, mainly be inducing the expression of hepatic Phase I and Phase II enzymes, especially of the cytochrome P450 family. Most of the toxic effects of PCBs are believed to be results of Ah receptor binding. Other PBCs are believed to interfere with calcium channels and/or change brain dopamine levels. PCBs can also cause endocrine disurption by altering the production of thyroid hormones and binding to estrogen receptors, which can stimulate the growth of certain cancer cells and produce other estrogenic effects, such as reproductive dysfunction. They will bioaccumulate by binding to receptor proteins such as uteroglobin. (A3, A4, A30, A66)
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1-Chloro-4-iodobenzene 2,4,5-trichloroiodobenzene 4-Chlorophenylboronic acid 4-chloro-aniline合成工艺路线路线简述
海关参考信息
- 2903911000-邻二氯苯
- 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
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📌 第三方产品分析报告
合成参考文献
参考文献:10.2165/00139709-200322040-00003
摘要:Lotti M. Pharmacokinetics and blood levels of polychlorinated biphenyls. Toxicol Rev. 2003;22(4):203–15. doi: 10.2165/00139709-200322040-00003.
参考文献:10.1016/j.tox.2018.05.004
摘要:Strapáčová S, Brenerová P, Krčmář P, Andersson P, van Ede KI, van Duursen MBM, van den Berg M, Vondráček J, Machala M. Relative effective potencies of dioxin-like compounds in rodent and human lung cell models. Toxicology. 2018 Jul 01;404-405():33–41. doi: 10.1016/j.tox.2018.05.004.
摘要:S116 | REFCCS | Collision Cross Section (CCS) Values from Literature | DOI:10.5281/zenodo.10932895
摘要:T14: Lewis RJ (1996). Sax's Dangerous Properties of Industrial Materials. 9th ed. Volumes 1-3. New York, NY: Van Nostrand Reinhold.
摘要:L4: ATSDR - Agency for Toxic Substances and Disease Registry (2000). Toxicological profile for polychlorinated biphenyls. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). http://www.atsdr.cdc.gov/toxprofiles/tp17.html
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