CAS: 2417-73-4; Methyl 2-Bromomethylbenzoate

该化合物是一种多溴化芳烃酯,通常用作有机合成的中间体,其主要结构特征--反应性苯并基溴和酯类--使其对进一步的功能化具有价值,包括核生殖替代和交叉反应.该化合物在制备药品,农用化学品和特殊化学品方面特别有用.该化合物在标准储存条件下的稳定性和特性完善的再活性简介增强了其在多步合成中的效用.该等级还允许直截了当的衍生,在下游应用中提供了灵活性.

结构式图片

欧盟法规

C&L通报

上下游产品

CAS号89-71-4 邻甲基苯甲酸甲酯 | CAS号2094-98-6 1,1'-偶氮(氰基环己烷) | CAS号74-95-3 二溴甲烷 | CAS号118-90-1 邻甲基苯甲酸 | CAS号933-88-0 邻甲基苯甲酰氯 | CAS号67-56-1 甲醇 | CAS号40819-28-1 2-(溴甲基)苯甲酰溴 | CAS号186581-53-3 重氮甲烷 | CAS号7115-89-1 2-(溴甲基)苯甲酸 | CAS号1046494-85-2 2-[(4-甲酰基苯氧基)甲基... | CAS号55453-87-7 伊索克酸 | CAS号55453-89-9 2-[(4-羧甲基苯氧基)甲基]苯甲酸 | CAS号15196-54-0 2-[2-(3-aminoph... | CAS号468751-38-4 2-(苯磺酰甲基)苯甲醛 | CAS号39221-42-6 (1-氧-1,3-二氢-异吲哚... | CAS号21733-94-8 2-(苯氧基甲基)苯甲酰氯 | CAS号203047-36-3 TERT-BUTYL 4-[3... | CAS号1966-89-8 2-[Β(2-噻吩基)乙烯基]苯甲酸 | CAS号87-41-2 苯酞

合成工艺路线路线简述

    2-溴甲基苯甲酸 反应生成2-溴甲基苯甲酸甲酯
    参考文献:Salkind,Zhurnal Russkago Fiziko-Khimicheskago Obshchestva,1914,Vol. 46,P. 510
    标题:Salkind,Zhurnal Russkago Fiziko-Khimicheskago Obshchestva,1914,Vol. 46,P. 510

    海关参考信息

    专利信息


    专利号:US-6252082-B1
    优先权日:1997-01-16
    标 题 :Pyridone derivatives, their preparation and their use as synthesis intermediates
    发明人:LASSALLE GILBERT; BELLEVERGUE PATRICE; BOURBIER JEAN-CLAUDE; GALTIER DANIEL; MARTIN VALERIE
    权利人:SANOFI SYNTHELABO
    摘要:The invention concerns compounds of formula (I)in which: R is -NO2 or -NHR3, R3 being hydrogen, -COR4 (R4 selected among (C1-C4) alkyl, aryl and aryl (C1-C4) alkyl, -COOR5 (R5 selected among (C1-C4) alkyl and aryl (C1-C4) alkyl), -CONHR6 or SO2R6 (R6 selected among (C1-C5) alkyl, aryl and aryl(C1-C4) alkyl), -SO2NR7R8 (R7 and R8 independently of each other represent hydrogen or (C1-C4) alkyl or form with the nitrogen atom a morpholine group), aryl (C1-C4) alkyl, R1 is a (C1-C4) alkyl group linear or branched, cyclo (C3-C8) alkyl, aryl optionally substituted, aryl (C1-C4) alkyl optionally substituted, heteroaryl, R2 is a hydrogen atom, a (C1-C4) alkyl or arylmethyl group, X is an oxygen or sulphur atom, a -CH2-, -SO2 or -NR1- group and Y is a hydrogen atom or (C1-C6) alkyl. The invention is applicable to synthesis intermediates.

    专利号:US-2009099367-A1
    优先权日:2006-03-06
    标题 :Process for preparing a leukotriene antagonist
    发明人:BESSA BELLMUNT JORDI; RAFECAS JANE LLORENC; PASTO AGUILA MIREIA; VERDAGUER ESPAULELLA XAVIER; GORDO CAMPON ESTHER
    权利人:FARMAPROJECTS S A
    摘要:Process for preparing montelukast or a pharmaceutically acceptable salt thereof, especially its sodium salt, that comprises the condensation of an aldehyde and 7-chloro-2-methylquinoline. Moreover, novel intermediates useful for the synthesis of montelukast are described as well as their preparation.

    专利号:US-9156840-B2
    优先权日:2010-06-18
    标题:D2 antagonists, methods of synthesis and methods of use
    发明人:LUEHR GARY W; SUNDARAM ARATHI; JAISHANKAR PRIYADARSHINI; PAYNE PHILIP W; DRUZGALA PASCAL
    权利人:ALTOS THERAPEUTICS LLC
    摘要:Provided are D 2 or D 3 antagonist compounds and pharmaceutical compositions of formula I n nand pharmaceutically acceptable salts thereof, or isomers thereof, wherein R 1 , R 2 and R 3 are as defined herein. The invention further comprises methods for making the compounds of the invention and methods for the treatment of conditions mediated by the dopamine D 2 or D 3 receptor from the compounds of the invention.

    专利号:US-5532408-A
    优先权日:1992-10-05
    标 题 :α-chain-modified isocarbacyclins and process for the production thereof
    发明人:KOGA MASAHIRO; TANAKA TOSHIO; FUJII TAKAO; MASEGI TSUKIO
    权利人:TEIJIN LTD
    摘要:PCT No. pct/jp93/01407 Sec. 371 Date Apr. 5, 1995 Sec. 102(e) Date Apr. 5, 1995 PCT Filed Oct. 1, 1993 PCT Pub. No. wo94/07838 PCT Pub. Date Apr. 14, 1995.Provided are alpha -chain-modified isocarbacyclins of which the alpha -chain is modified with a phenylene group, a cycloalkylene group or a thiophendiyl group, and these alpha -chain-modified isocarbacyclins show the activity for inhibiting the DNA synthesis of human smooth muscle cell and are expected to be capable of inhibiting the hypertrophy of a blood vessel.

    专利号:US-11180523-B2
    优先权日:2016-01-04
    标 题 :Design, synthesis and use of synthetic nucleotides comprising charge mass tags
    发明人:O'HALLORAN JONATHAN J; HEDLEY JOSEPH H
    权利人:QUANTUMDX GROUP LTD
    摘要:Embodiments of the present disclosure relate generally to reporter compositions which are synthetic nucleotides that comprise nucleotides with a high charge mass moiety attached thereto via a linker molecule. The linker molecules can vary in length in part to enable the high charge mass moiety to extend out from a DNA polymerase complex so that polymerization may not be influenced.

    专利号:US-6025177-A
    优先权日:1998-03-30
    标题 :Asymmetric grignard synthesis with cyclic 1,2 aminoalcohols
    发明人:SENANAYAKE CHRIS HUGH; BAKALE ROGER P; FANG QUN KEVIN; GROVER PAUL TIMOTHY; HEEFNER DONALD L; ROSSI RICHARD F; WALD STEPHEN ALAN
    权利人:SEPRACOR INC
    摘要:Processes for preparing a single enantiomer of an alpha , alpha -disubstituted- alpha -hydroxy acetic acid, especially cyclohexylphenylglycolic acid (CHPGA), is disclosed. The processes employ cyclic 1,2-aminoalcohols as chiral auxiliaries by forming diastereomeric esters of aminoalcohols or diastereomeric amides of oxazolidines. Intermediates useful in the process are also disclosed.
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    合成参考文献


    摘要:Pitaval, A.; Echavarren, A. M., Science of Synthesis: Cross Coupling and Heck-Type Reactions, (2012) 1, 580.
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