CAS: 2115-91-5; From Dendrobium Nobile

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上下游产品

formaldehyd 8,11.04,12>tridecan-9-one(1S,4S,7S,8R,11R,12R,13S)-13-isopropyl-12-methyl-10-oxa-2-azatetracyclo5.4.1.1.8,11.04,12tridecan-9-one (+)-trans-verbenol (+)-(1R,2S,6R)-6-isopropyl-3-methyl-2-methylamino-cyclohex-3-enol

合成工艺路线路线简述

    📜Methyl (1S,4S,7S,8R,9S,11R)-2,11-Dimethyl-10-Oxo-9-Propan-2-Yl-2-Azatricyclo[5.3.1.04,11]Undecane-8-Carboxylate置于sodium Tetrahydroborate体系中,用 异丙醇 用作溶剂,化学反应 77.0H,以65%的收率获得石斛碱
    参考文献:(-)-石end碱的全合成
    标题:(-)-石end碱的全合成
    摘要:级联为生物碱:(-)-石end碱的18个步骤的总合成是基于与关键胺基的反应级联(参见方案,Bn =苄基).胺是级联反应的引发剂,为在c11和c3处安装立构中心提供了有效的方法.仅当在不分离中间体的情况下进行转化时,整体转化才立体选择性地发生.
    Doi:10.1002/anie.201108564

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    专利信息


    专利号:CN-117305120-A
    优先权日:2023-08-24
    标 题 :Application of a fungus of the genus Glycophyllum in promoting the synthesis of Bleucophylla glycosides

    专利号:CN-117305118-B
    优先权日:2023-08-24
    标 题:Application of a fungus of the genus Glechoma in promoting the synthesis and/or accumulation of polysaccharides in Bletilla striata

    专利号:CN-117305118-A
    优先权日:2023-08-24
    标题 :Application of a fungus of the genus Glycophyllum in promoting the synthesis and/or accumulation of polysaccharides in white jellyfish

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    主要参考文献


    1: Deng W, Ding Z, Wang Y, Zou B, Zheng J, Tan Y, Yang Q, Ke M, Chen Y, Wang S, Li X. Dendrobine attenuates osteoclast differentiation through modulating ROS/NFATc1/ MMP9 pathway and prevents inflammatory bone destruction. Phytomedicine. 2022 Feb;96:153838. doi: 10.1016/j.phymed.2021.153838. Epub 2021 Nov 6. 36(21):5393-5399. doi: 10.1080/14786419.2021.2019731. Epub 2021 Dec 20. 105(18):6597-6606. doi: 10.1007/s00253-021-11534-1. Epub 2021 Aug 31.
    13:890733. doi: 10.3389/fmicb.2022.890733.
    5: Feng Y, Jia B, Feng Q, Zhang Y, Chen Y, Meng J. Dendrobine attenuates gestational diabetes mellitus in mice by inhibiting Th17 cells. Basic Clin Pharmacol Toxicol. 2021 Mar;128(3):379-385. doi: 10.1111/bcpt.13524. Epub 2020 Nov 11. 83(5):1125-1137. doi: 10.1002/ddr.21937. Epub 2022 Apr 13. 12(1):4452-4463. doi: 10.1080/21655979.2021.1956672.

    合成参考文献


    摘要:Shi, L.; Yang, Z., Science of Synthesis: Applications of Domino Transformations in Organic Synthesis, (2015) 1, 601.
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