CAS: 2002-24-6; 2-Aminoethanol Hydrochloride

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104-63-2 105496-31-9 109-85-3

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CAS号141-43-5 2-氨基乙醇 | CAS号94421-68-8 花生四希酸乙醇胺 | CAS号24070-16-4 2-(三苯甲基氨基)乙醇 | CAS号870-24-6 2-氯乙胺盐酸盐 | CAS号26690-80-2 N-(叔丁氧羰基)乙醇胺 | CAS号109-01-3 N-甲基哌嗪 | CAS号109-81-9 N-甲基乙二胺 | CAS号77987-49-6 2-(羰基苄氧氨基)-1-乙醇 | CAS号75948-77-5 4,6-二甲基-1H-吲哚 | CAS号1071-23-4 磷酸乙醇胺 | CAS号105496-31-9 FM°C-甘氨醇

2-硝基乙醇置于c36H56Cl3Crn2O,Magnesium,频那醇硼烷,盐酸体系中,用 四氢呋喃,水,乙酸乙酯 用作溶剂,化学反应 24.0H,以85%的收率获得乙醇胺盐酸盐
参考文献:用铬催化的环状(烷基)(氨基)卡宾配体促进的硝基脱氧硼氢化反应:范围,机制和应用
标题:用铬催化的环状(烷基)(氨基)卡宾配体促进的硝基脱氧硼氢化反应:范围,机制和应用
摘要:利用 N-杂环卡宾作为非无害配体促进转化的过渡金属催化尚未得到很好的研究.我们在这里报告了具有成本效益的铬催化的环状(烷基)(氨基)卡宾(caac)配体促进的硝基脱氧硼氢化反应.使用 1 Mol % 的 Caac-Cr 预催化剂,将 Hbpin 添加到硝基支架上会导致脱氧,从而保留各种可还原的官能团和敏感基团对硼氢化的相容性,从而提供一种温和,化学选择性和易于形成的策略苯胺,以及杂芳基和脂肪胺衍生物,具有广泛的范围和特别高的转换数(高达 1.8 x 106).基于理论计算的机械研究,表明caac配体在促进hbpin氢化物极性反转中起重要作用;它用作 H 穿梭以促进脱氧硼氢化.通过这种策略制备的几种市售药物突出了其在药物化学中的潜在应用.
Doi:10.1021/jacs.0C12318

专利信息

专利号:US-7576234-B2
优先权日:2002-05-15
标题 :Synthesis of 2-alkyl amino acids
发明人：CHORGHADE MUKUND S; GURJAR MUKUND K; MOHAPATRA DEBENDRA K
权利人:GENZYME CORP
摘要:Non-natural amino acids such as 2-alkylated amino acids allow for the synthesis of a wider variety of peptidal and non-peptidal pharmaceutically active agents. A method of preparing a 2-alkyl amino acid involves a Michael-type addition of a nucleophile to a dialkyl 2-methylidenylpropan-1,3-dioate and the conversion of a ester moiety into an amino moiety. The present invention also discloses a method of preparing a class of iron chelating agents related to desferrithiocin, all of which contain a thiazoline ring. In this method, an aryl nitrile or imidate is condensed with cysteine, a 2-alkyl cysteine, or a cysteine ester.

专利号:US-7183396-B2
优先权日:1999-06-15
标题:Linvin, a novel inhibitor of apoptosis protein
发明人：GOMES BRUCE C; KASOF GARRETT M; PROSSER JUDITH C
权利人:GOMES BRUCE C; KASOF GARRETT M; PROSSER JUDITH C
摘要:A novel isolated and purified human protein inhibitor of apoptosis, termed livin, is described. A cDNA sequence which encodes the native inhibitor of apoptosis (livin) is disclosed as well as the structural coding region and the amino acid residue sequence. Molecular sequences are provided for the design and synthesis of entities that modulate biological and/or pharmacological activity of the native biomolecule. Methods are provided which employ the sequences to identify compounds that modulate biological and/or pharmacological activity of the native biomolecule. Biologically-effective antisense molecules as well as dominant negative mutant versions of the livin protein which are suitable for therapeutic are also provided. The invention is also drawn toward the study, prevention, diagnosis, and treatment of pathophysiological disorders related to apoptosis.

专利号:US-5688763-A
优先权日:1987-06-12
标题 :Compositions and methods for the synthesis of growth hormone receptor and growth hormone binding protein
发明人：HAMMONDS JR R GLENN; LEUNG DAVID W; SPENCER STEVEN A; WOOD WILLIAM I; COLOSI PETER CAMERON
摘要:Growth hormone receptor and growth hormone binding protein are purified enabling amino acid sequence and DNA isolates coding for growth hormone receptor and growth hormone binding protein and methods of obtaining such DNA are provided, together with expression systems for recombinant production of growth hormone receptor and growth hormone binding protein. Therapeutically useful forms of the growth hormone receptor and growth hormone binding protein and anti-receptor antibodies are described.

专利号:US-4350764-A
优先权日:1980-03-10
标 题 :Microbiological synthesis of beta endorphin
发明人：BAXTER JOHN D; FETTES IVY; SHINE JOHN
权利人:UNIV CALIFORNIA
摘要:DNA comprising the naturally occurring nucleotide sequence coding for amino acids 44-90 of β-lipotropin and including the entire coding region for β-endorphin with the exception of the C-terminal glutamine was modified, transferred to an expression transfer vector, and expressed as a fusion protein. The fusion protein was further modified in vitro to yield mature β-endorphin. β-endorphin was purified from a bacterial lysate. The structure and biological activity of the resulting product was proven by immunological assay, and by two independent assays designed to demonstrate biological activity.

专利号:US-5057417-A
优先权日:1987-06-12
标题 :Compositions and methods for the synthesis of growth hormone receptor and growth hormone binding protein
发明人：HAMMONDS R GLENN; LEUNG DAVID W; SPENCER STEVEN A; WOOD WILLIAM I
权利人:GENENTECH INC
摘要:Growth hormone receptor and growth hormone binding protein are purified enabling amino acid sequence and DNA isolates coding for growth hormone receptor and growth hormone binding protein and methods of obtaining such DNA are provided, together with expression systems for recombinant production of growth hormone receptor and growth hormone binding protein. Therapeutically useful forms of the growth hormone receptor and growth hormone binding protein and anti-receptor antibodies are described.

专利号:US-6797479-B2
优先权日:1995-04-04
标题 :Reagents and methods for the detection and quantification of vancomycin in biological fluids
发明人：ADAMCZYK MACIEJ; BRATE ELAINE M; PERKOWITZ MARY M; REGE SUSHIL D
权利人:ABBOTT LAB
摘要:Immunoassay reagents, methods and test kits for the specific quantification of vancomycin in a test sample are disclosed. The reagent comprises antibodies prepared with immunogens of FIG. 6 wherein P is an immunogenic carrier material and X is a linking moiety. Also described is the synthesis of labeled reagents of FIG. 8 wherein Q is a detectable moiety, preferably fluorescein or a fluorescein derivative, and X is a linking moiety.