CAS: 176969-34-9; 3-(Difluoromethyl)-1-Methyl-1H-Pyrazole-4-Carboxylic Acid

相似化合物

141573-95-7 1094484-55-5 113100-53-1

上下游产品

Methyl 3-(Difluoromethyl)-1-Methyl-1H-Pyrazole-4-Carboxylate
3-二氟甲基-1-甲基吡唑-4-甲酸乙酯 Ethyl 3-(Difluoromethyl)-1-Methyl-1H-Pyrazole-4-Carboxylate 141573-95-7
Ethylene Glycol Bis((3-(Difluoromethyl)-1-Methyl-1H-Pyrazol-4-yl)Carboxylate)
3-(二氟甲基)-1-甲基-1H-吡唑-4-羧醛 3-(Difluoromethyl)-1-Methyl-1H-Pyrazole-4-Carbaldehyde 1094484-55-5
Ethyl 3-(Chlorodifluoromethyl)-1-Methyl-1H-Pyrazole-4-Carboxylate 1356449-71-2
1-甲基-5-(二氟甲基)-1H-吡唑-4-羧酸乙酯 Ethyl 1-Methyl-5-Difluoromethylpyrazole-4-Carboxylate 851725-98-9
3-(二氟甲基)-1-甲基-1H-吡唑-4-羰酰氯 3-(Difluoromethyl)-1-Methyl-1H-Pyrazole-4-Carbonyl Chloride 141573-96-8
1-(3-(二氟甲基)-1-甲基-1H-吡唑-4-基)乙-1-酮 1-(3-(Difluoromethyl)-1-Methyl-1H-Pyrazol-4-yl)Ethanone 1814920-62-1 3-(Dichloromethyl)-1-Methyl-1H-Pyrazole-4-Carboxylic Acid 1415313-49-3 1-Methyl-3-Difluoromethyl-4-Pyrazolecarbonitrile 1049772-84-0

Ethyl 4,4-Difluoro-2-[1-{n-Methyl-N'-[1-Phenylmethylidene]Hydrazino}-Methylidene]-3-Oxobutyrate置于硫酸,水,Sodium Hydroxide体系中,用 氯仿 用作溶剂,化学反应 2.0H,反应生成3-(二氟甲基)-1-甲基-1H-吡唑-4-羧酸
参考文献:一种卤素取代中间体化合物及其制备方法和应用
标题:一种卤素取代中间体化合物及其制备方法和应用
摘要:本发明涉及一种卤素取代中间体化合物的制备方法,如式ⅶ所示的化合物与如式ⅵ所示的卤代乙酰卤衍生物反应生成如式ⅷ所示的卤素取代中间体化合物.本发明涉及一种卤素取代中间体化合物制备吡唑衍生物的制备方法,如式ⅷ所示的卤素取代中间体化合物与甲基肼反应,关吡唑环生成如式ⅳ所示的卤素取代烷基‑1‑甲基吡唑衍生物;或与甲基肼苯甲醛腙反应,生成如式ⅲ所示的腙化合物,在酸的作用下,关吡唑环生成如式ⅳ所示的卤素取代烷基‑1‑甲基吡唑衍生物.本发明还涉及中间体化合物的结构.本发明的卤素取代中间体化合物和吡唑衍生物的制备方法适于产业化生产.

专利信息

专利号:US-12134603-B2
优先权日:2022-08-24
标 题:Synthesis method for N-methyl-3-substituted methyl-4-pyrazolamide derivative and N-methyl-3-substituted methyl-4-pyrazolic acid
发明人：LIU SHENGXUE; SHI YINTAO; GONG QIANG; Zhong Sufang; ZHANG JIANJIANG; QIAN XIAOYUAN; GUO FANG; CHEN RUJUN; JIAN XIAOYING
权利人:SHAOXING SHANGYU XIN YINBANG BIOCHEMICAL CO LTD
摘要:The present application relates to a synthesis method for N-methyl-3-substituted methyl-4-pyrazolamide derivative and N-methyl-3-substituted methyl-4-pyrazolic acid, including the following steps: step S1: synthesis of intermediate E; step S2: synthesis of intermediate D; step S3: synthesis of intermediate C; step S4: synthesis of N-methyl-3-substituted methyl-4-pyrazolamide derivative; and synthesis of N-methyl-3-substituted methyl-4-pyrazolic acid by decomposition of N-methyl-3-substituted methyl-4-pyrazolamide derivative.

专利号:WO-2021074309-A1
优先权日:2019-10-16
标 题:1-(3-quinolyl)-3,4-dihydroisoquinoline derivatives as fungicides for combating specific phytopathogens
发明人：WEISS MATTHIAS; QUARANTA LAURA; BOU HAMDAN FARHAN; MAHAJAN ATUL; WILLIAMS SIMON; KILARU JAGADEESH; SEN INDIRA; BIERI STEPHANE; DIGGELMANN MARTIN
权利人:SYNGENTA CROP PROTECTION AG
摘要:1-(3-quinolyl)-3,4-dihydroisoquinoline derivatives of formula (I) as well as a method of combating, preventing or controlling the phytopathogens Mycosphaerella graminicola (Septoria tritici), Fusarium culmorum, Gibberella zeae (Fusarium graminearum) and Monographella nivalis (Microdochium nivale), which comprises applying to the phytopathogen, to the locus of the phytopathogen, or to a plant susceptible to attack by the phytopathogen, or to propagation material thereof, a fungicidally effective amount of a 1-(3-quinolyl)-3,4-dihydroisoquinoline derivative of formula (I). The present description discloses the synthesis of exemplary compounds, formulation examples, relevant biological data (antifungal activity against Mycosphaerella graminicola (Septoria tritici), Fusarium culmorum, Gibberella zeae (Fusarium graminearum) and Monographella nivalis (Microdochium nivale) when spayed on plants), as well as comparative data against three prior art compounds (e.g. pages 52 to 85; formulation examples; examples A1 to A3; table E; compounds E.01 to E.187; biological examples). Exemplary compounds are e.g.: 5-bromo-1-(8-fluoro-3-quinolyl)spiro[4H-isoquinoline-3,1'- cyclopropane] (example A1) 5-bromo-1-(8-fluoro-3-quinolyl)-3,3-dimethyl-4H-isoquinoline (example A2) 1-(8-fluoro-3-quinolyl)-3,3-dimethyl-4H-isoquinoline-5-carbonitrile (example A3)

专利号:WO-2021074311-A1
优先权日:2019-10-16
标题:1-(3-quinolyl)-1,2,3,4-tetrahydroisoquinoline derivatives as fungicides for combating specific phytopathogens
发明人：WEISS MATTHIAS; QUARANTA LAURA; BOU HAMDAN FARHAN; MAHAJAN ATUL; WILLIAMS SIMON; KILARU JAGADEESH; BIERI STEPHANE; DIGGELMANN MARTIN
权利人:SYNGENTA CROP PROTECTION AG
摘要:1-(3-quinolyl)-1,2,3,4-tetrahydroisoquinoline derivatives of formula (I) as well as a method of combating, preventing or controlling the phytopathogens Mycosphaerella graminicola (Septoria tritici), Fusarium culmorum, Gibberella zeae (Fusarium graminearum) and Monographella nivalis (Microdochium nivale), which comprises applying to the phytopathogen, to the locus of the phytopathogen, or to a plant susceptible to attack by the phytopathogen, or to propagation material thereof, a fungicidally effective amount of a 1-(3-quinolyl)-1,2,3,4-tetrahydroisoquinoline derivatives of formula (I). The present description discloses the synthesis of exemplary compounds, formulation examples, relevant biological data (antifungal activity against Mycosphaerella graminicola, Monographella nivalis, Fusarium culmorum and/or Gibberella zeae when spayed on plants) (e.g. pages 47 to 55; examples A1 and A2; compounds E.01 to E.17; table E). An exemplary compounds is e.g.: 3-(5-bromo-3,3-dimethyl-2,4-dihydro-1 H-isoquinolin-1-yl)-8-fluoro- quinoline (example A1)

专利号:CN-117658919-A
优先权日:2023-12-06
标题 :Alkaline ionic liquid promotes efficient synthesis of 3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid

专利号:CA-3170288-A1
优先权日:2020-03-04
标题:Synthesis of novel ep4 antagonist and use in cancer and inflammation

专利号:EP-3650443-A1
优先权日:2018-11-07
标题 :Continuous flow synthesis of fluorinated or non-fluorinated pyrazoles