对氯苯乙酮置于potassium Tert-Butylate,甲基三苯基溴化膦体系中,用 乙醚 用作溶剂,化学反应生成对氯甲基苯乙烯 参考文献:Rapid Access To Cyclopentadiene Derivatives Through Gold-Catalyzed Cycloisomerization Of Ynamides With Cyclopropenes By Preferential Activation Of Alkenes Over Alkynes 标题:Rapid Access To Cyclopentadiene Derivatives Through Gold-Catalyzed Cycloisomerization Of Ynamides With Cyclopropenes By Preferential Activation Of Alkenes Over Alkynes 摘要:双键活化:当前的转化是金催化下烯烃优先活化而不是炔烃的罕见例子. Doi:10.1039/c7Cc01368J
专利号:US-9024045-B2 优先权日:2012-06-04 标题 :Process for preparing styrene derivatives 发明人:GOTTA MATTHIAS; LEHNEMANN BERND WILHELM; VON WANGELIN JACOBI AXEL; GUELAK SAMET 权利人:SALTIGO GMBH 摘要:A process is provided which allows the synthesis of a large number of styrene derivatives with formation of C—C bonds, with use being possible of economically advantageous substrates, readily available carbon nucleophiles, and both inexpensive and environmentally unproblematic catalyst systems, permitting reaction under mild conditions and a high compatibility with functional groups on the reactants involved.
专利号:US-9890111-B2 优先权日:2008-07-21 标题 :Crystal structure of bifunctional transglycosylase PBP1b from E. coli and inhibitors thereof 发明人:WONG CHI HUEY; MA CHE ALEX; CHENG TING JEN RACHEL; CHENG WEI CHIEH 权利人:ACADEMIA SINICA 摘要:The crystal structure at 2.16 â„« resolution of the full-length bacterial bifunctional transglycosylase penicillin-binding protein 1b (PBP1b) from Escherichia coli , in complex with its inhibitor moenomycin, is provided. The atomic coordinates of the complex as well as the moenomycin binding site are provided. Three dimensional structures of amino acid residues involved in moenomycin binding and transglycosylation activity are identified. Binding site for peptidoglycan synthesis inhibitors comprising inhibitor-binding site comprises amino acid residues from at least one of transglycosylase (TG), UvrB domain 2 homolog (UB2H) and transmembrane (TM) domains of PBP1b are identified at an atomic level of resolution. Methods for rational drug design based on the atomic coordinates are provided. Methods for screening for antibiotics based on anisotropic binding assay and transglycosylase inhibitor assays are provided. Novel antibiotics based on the screening assays of the invention are disclosed.
专利号:EP-3008197-A2 优先权日:2013-06-13 标题 :Method for biocatalytic synthesis of substituted or unsubstituted phenylacetic acids and ketones having enzymes of microbial styrene degradation
专利号:US-2016186217-A1 优先权日:2013-06-13 标 题 :Method for biocatalytic synthesis of substituted or unsubstituted phenylacetic acids and ketones having enzymes of microbial styrene degradation
专利号:WO-2011066482-A2 优先权日:2009-11-25 标题 :Chiral synthesis of isoxazolines, isoxazoline compounds, and uses thereof
专利号:WO-2014198871-A2 优先权日:2013-06-13 标题 :Method for biocatalytic synthesis of substituted or unsubstituted phenylacetic acids and ketones having enzymes of microbial styrene degradation
参考标题:Copper-Catalyzed Aminodifluoroalkylation Of Alkenes With α-Bromodifluoroacetamides: Synthesis Of 3,3-Difluoropyrrolidin-2-Ones 作者:Yunhe Lv,Weiya Pu,Qingqing Wang,Qian Chen,Jiejie Niu,Qian Zhang |发布日期:2017.9.18 摘要:Copper‐catalyzed External‐oxidant‐free Regioselective Aminodifluoroalkylation Of Alkenes With Readily Available α‐bromodifluoroacetamides Was Realized. This Reaction Exhibits Good Functional Group Tolerance With Respect To Alkenes And α‐bromodifluoroacetamides In Affording 3,3‐difluoropyrrolidin‐2‐ones. A Mechanism Involving Copper‐catalyzed Generation Of A Difluoroalkyl Radical Is Proposed.
合成参考文献
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