CAS: 1392136-43-4; (Z)-3-(3-(3,5-Bis(Trifluoromethyl)Phenyl)-1H-1,2,4-Triazol-1-yl)-N'-(Pyridin-2-yl)Acrylohydrazide

上下游产品

3-(3,5-bis(trifluoromethyl)phenyl)-1H-1,2,4-triazole (Z)-isopropyl 3-(3-(3,5-bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylate pyrid-2-ylhydrazine (Z)-3-(3-(3,5-bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylic acid

📜3,5-二(三氟甲基)硫代苯甲酰胺置于三乙烯二胺,水,一水合肼,1-丙基磷酸酐,N,N-二异丙基乙胺,Lithium Hydroxide体系中,用 四氢呋喃,二氯甲烷,乙酸乙酯,N,N-二甲基甲酰胺 用作溶剂,化学反应 21.0H,反应生成Verdinexor(kpt-335)抑制剂
参考文献: Hydrazide Containing Nuclear Transport Modulators And Uses Thereof[fr] Modulateurs De Transport Nucléaire Contenant De L'Hydrazide Et Leurs Utilisations
标题: Hydrazide Containing Nuclear Transport Modulators And Uses Thereof[fr] Modulateurs De Transport Nucléaire Contenant De L'Hydrazide Et Leurs Utilisations
摘要:这项发明通常与核运输调节剂有关,例如crm1抑制剂,更具体地涉及一种由结构式(I)表示的化合物,或其药学上可接受的盐,其中变量的值和备选值如本文所定义和描述.该发明还包括合成和使用结构式i的化合物,或其药学上可接受的盐或组合物,例如在与crm1活性相关的生理状况的治疗,调节和/或预防中的应用.

专利信息

专利号:US-9714226-B2
优先权日:2011-07-29
标题:Hydrazide containing nuclear transport modulators and uses thereof
发明人：SANDANAYAKA VINCENT P; SHACHAM SHARON; MCCAULEY DILARA; SHECHTER SHARON
权利人:KARYOPHARM THERAPEUTICS INC
摘要:The invention generally relates to nuclear transport modulators, e.g., CRM1 inhibitors, and more particularly to a compound represented by structural formula I: n nor a pharmaceutically acceptable salt thereof, wherein the values and alternative values for the variables are as defined and described herein. The invention also includes the synthesis and use of a compound of structural formula I, or a pharmaceutically acceptable salt or composition thereof, e.g., in the treatment, modulation and/or prevention of physiological conditions associated with CRM1 activity.

专利号:US-9428490-B2
优先权日:2011-07-29
标 题 :Nuclear transport modulators and uses thereof
发明人：SANDANAYAKA VINCENT P; SHACHAM SHARON; KAUFFMAN MICHAEL; SHECHTER SHARON; MCCAULEY DILARA; LANDESMAN YOSEF; SENAPEDIS WILLIAM; SAINT-MARTIN JEAN-RICHARD
权利人:SANDANAYAKA VINCENT P; SHACHAM SHARON; KAUFFMAN MICHAEL; SHECHTER SHARON; MCCAULEY DILARA; LANDESMAN YOSEF; SENAPEDIS WILLIAM; SAINT-MARTIN JEAN-RICHARD; KARYOPHARM THERAPEUTICS INC
摘要:The invention generally relates to nuclear transport modulators, e.g CRM1 inhibitors, and more particularly to a compound represented by formula (I): or a pharmaceutically acceptable salt thereof, wherein the variables are as defined and described herein. The invention also includes the synthesis and use of a compound of structural formula (I), or a pharmaceutically acceptable salt or composition thereof, e.g, in the treatment, modulation and/or prevention of physiological conditions associated with CRM1 activity.

专利号:CN-116514773-A
优先权日:2023-04-24
标题 :Verdinexor (KPT-335) and synthesis method of hydrochloride thereof

专利号:CN-116514773-B
优先权日:2023-04-24
标题 :Verdinexor (KPT-335) and synthesis method of hydrochloride thereof